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Current Drug Metabolism


ISSN (Print): 1389-2002
ISSN (Online): 1875-5453

Review Article

Herb-Drug Interactions and Their Impact on Pharmacokinetics: An Update

Author(s): Wenhao Cheng, Kexin Xia, Siyang Wu* and Yingfei Li*

Volume 24, Issue 1, 2023

Published on: 23 January, 2023

Page: [28 - 69] Pages: 42

DOI: 10.2174/1389200224666230116113240

Price: $65


Herb medicine has a long history of application and is still used worldwide. With the development of complementary and alternative medicine, the interaction between herb and drugs has attracted more and more attention. Herb-drug interactions (HDI) could cause decreased efficiency, increased toxicity, and affect the drug absorption and disposition processes due to the interference of their pharmacological or pharmacokinetic effects. Hence, the mechanisms and results of herb-pharmacokinetic interactions should be comprehensively summarized. Here, we have summarized the mechanisms of HDI and pharmacokinetic interactions in the last ten years based on searching on PubMed, Science Direct, and Web of Science with different keywords. Besides, the pharmacokinetic interactions were related to nine commonly used herbs and drugs, including Ginseng, Salvia miltiorrhiza, Ginkgo biloba, Garlic, Coptis chinensis, St. John's wort, Ginger, Licorice, Silythistle and Fructus Schisandrae. This review provides an overview of HDI to provide a reference for the rational and safe clinical use of herbs and drugs.

Keywords: Traditional Chinese medicine, Herb-drug interaction, cytochrome, transporter, enzyme, pharmacokinetic interaction.

Graphical Abstract
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