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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

NR2F1-AS1: A Functional Long Noncoding RNA in Tumorigenesis

Author(s): Jiahui Hu, Fan Peng, Xinyan Qiu, Jingjie Yang, Jing Li, Chuyue Shen and Chengfu Yuan*

Volume 30, Issue 37, 2023

Published on: 02 February, 2023

Page: [4266 - 4276] Pages: 11

DOI: 10.2174/0929867330666230112165503

Price: $65


Background: NR2F1-AS1 is a long non-coding RNA (lnc RNA) that is involved in different biological processes. It plays an integral role in the pathophysiology of human diseases, especially tumorigenesis and progression. Therefore, it may be a promising target for numerous tumor biotherapeutics. The current review study aimed to show the pathophysiological activities and processes of RNA NR2F1-AS1 in cancer cells.

Methods: The contents of the present review were based on information obtained from PubMed. In the data search, “NR2F1-AS1” was chosen as the first keyword, whereas “cancer” was chosen as the second keyword. This review selected and summarized studies published between 2019-2021, concerning the biological functions and mechanisms of NR2F1-AS1 in the development of tumorigenesis.

Results: It was found that NR2F1-AS1 regulates a variety of biological activities such as proliferation, invasion, migration, and apoptosis. It acts as an oncogene because it is abnormally expressed and promotes the progression of cancer in a variety of malignancies, including esophageal squamous cell carcinoma, non-small cell lung cancer, breast cancer, neuroblastoma, endometrial cancer, thyroid cancer, and gastric cancer. However, it was evident that NR2F1-AS1 inhibits the progression of cancer in cervical squamous cell carcinoma.

Conclusion: NR2F1-AS1 is a potential new biomarker and therapeutic target for the treatment of different cancers.

Keywords: NR2F1-AS1, long non-coding RNA, ceRNA, cancer, proliferating, tumorigenesis.

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