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Current Stem Cell Research & Therapy


ISSN (Print): 1574-888X
ISSN (Online): 2212-3946

Review Article

The Role of Mesenchymal Stem Cells in Cancer Immunotherapy

Author(s): Yueshui Zhao, Xianmei Zhong, Fukuan Du, Xu Wu, Mingxing Li, Qinglian Wen, Jing Shen, Yu Chen, Xinyi Zhang, Zhongming Yang, Ying Deng, Xiang Liu, Chang Zou*, Yu Du* and Zhangang Xiao*

Volume 18, Issue 8, 2023

Published on: 23 January, 2023

Page: [1056 - 1068] Pages: 13

DOI: 10.2174/1574888X18666230103120302

Price: $65


Mesenchymal stem cells (MSCs) are getting attention in the field of cancer immunotherapy. The main effects of MSCs on tumors are homing and regulation of inflammatory and immune responses. Indeed, cancer immunotherapy has become a promising treatment and MSCs play a potential role in regulating the efficacy of immunotherapy. In addition, MSCs are an ideal carrier for immunomodulatory protein transmission. As such MSCs combined with immunotherapy drugs could act synergistically against tumors, throwing a great impact on cancer therapy. And MSCs may have potential in the treatment of cytokine storm or cytokine release syndrome (CRS). It is assumed that MSCs can form chimeric antigen receptor MSCs (CAR-MSCs). Whether CAR-MSCs can provide a new idea of cancer immunotherapy is unknown. It is a prime time to review the latest progress of MSCs in cancer immunotherapy, in order to clarify to fully understand the role of MSCs in cancer therapy in clinical practice.

Keywords: Mesenchymal stem cells, tumor, cancer immunotherapy, cytokine storm, chimeric antigen receptor, cellular immune cell therapy (CAR-T).

Graphical Abstract
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