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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Role of Non-coding RNA in the Pathogenesis of Intestinal Ischemia- Reperfusion Injury

Author(s): Jianmin Zhang, Zhenzhen Liu, Yongqiang Liu, Yajing Shi, Feng Chen and Yufang Leng*

Volume 30, Issue 36, 2023

Published on: 13 January, 2023

Page: [4130 - 4148] Pages: 19

DOI: 10.2174/0929867330666221219094145

Price: $65


Intestinal ischemia-reperfusion injury is a relatively common clinical condition that seriously threatens the prognosis of patients; however, the exact mechanism of intestinal ischemia-reperfusion injury has not been clarified. Recent studies have found that noncoding RNAs, including but not limited to lncRNA, circRNA, and miRNA, play an important role in the pathogenesis of intestinal ischemia-reperfusion. The findings cited in this paper reveal the expression, function, and mechanism of noncoding RNAs during intestinal ischemia-reperfusion. The mechanistic roles of noncoding RNAs in the occurrence and development of intestinal ischemia-reperfusion are discussed, including cell proliferation, autophagy, oxidative stress, apoptosis, oxidative stress, iron death, and many other aspects. However, many unknown mechanisms of association between noncoding RNAs and intestinal ischemia-reperfusion remain to be investigated.

Keywords: Intestine, ischemia-reperfusion injury, noncoding RNA, micro RNA, circular RNA, long noncoding RNA.

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