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Cardiovascular & Hematological Disorders-Drug Targets

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ISSN (Print): 1871-529X
ISSN (Online): 2212-4063

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Research Article

In vivo Antihyperglycemic and Antidyslipidemic Effects of L-Tartaric Acid

Author(s): Ayoub Amssayef and Mohamed Eddouks*

Volume 22, Issue 3, 2022

Published on: 20 December, 2022

Page: [185 - 198] Pages: 14

DOI: 10.2174/1871529X23666221202091848

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Abstract

Aims: The aim of the study was to investigate the antihyperglycemic effect of L-Tartaric acid.

Background: L-Tartaric acid is a natural product with possible beneficial effects on health.

Objective: The goal of this work was to evaluate the antihyperglycemic and antidyslipidemic effects of L-Tartaric acid (L-TA) in rats.

Materials and Methods: In the first model, the effects of L-TA (10 and 40 mg/kg) on diabetes conditions induced by streptozotocin (STZ) in rats were investigated. In the second model, the effects of L-TA (40 and 80 mg/kg) on dyslipidemia induced by tyloxapol (Triton WR-1339) in rats were assessed.

Results: L-TA (40 mg/kg) had improved all studied parameters. L-TA at 40 mg/kg was able to significantly reduce glycaemia, improve oral glucose tolerance (OGT), increase glycogen content in liver and extensor digitorum longus (EDL) muscle, and ameliorate the lipidic profile and atherogenic indices in STZ-diabetic rats.

Conclusion: L-Tartaric acid was able to exhibit antihyperglycemic and antidyslipidemic effects in STZ-induced diabetic rats. Moreover, the antidyslipidemic effect of L-Tartaric acid was confirmed in tyloxapol-induced hyperlipidemic rats.

Keywords: L-Tartaric acid, streptozotocin, tyloxapol, diabetes, dyslipidemia, natural product.

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