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Current Bioinformatics


ISSN (Print): 1574-8936
ISSN (Online): 2212-392X

Research Article

DHOSGR: lncRNA-disease Association Prediction Based on Decay High-order Similarity and Graph-regularized Matrix Completion

Author(s): Guobo Xie, Zelin Jiang, Zhiyi Lin*, Guosheng Gu, Yuping Sun, Qing Su, Ji Cui and Huizhe Zhang

Volume 18, Issue 1, 2023

Published on: 23 December, 2022

Page: [92 - 104] Pages: 13

DOI: 10.2174/1574893618666221118092849

Price: $65


Background: It has been shown in numerous recent studies that long non-coding RNAs (lncRNAs) play a vital role in the regulation of various biological processes, as well as serve as a basis for understanding the causes of human illnesses. Thus, many researchers have developed matrix completion approaches to infer lncRNA–disease connections and enhance prediction performance by using similarity information.

Objective: Most matrix completion approaches are solely based on the first-order or second-order similarity between nodes, and higher-order similarity is rarely considered. In view of this, we developed a computational method to incorporate higher-order similarity information into the similarity network with different weights using a decay function designed by a random walk with restart (DHOSGR).

Methods: First, considering that the information will decay as the distance increases during network propagation, we defined a novel decay high-order similarity by combining the similarity matrix and its high-order similarity information through a decay function to construct a similarity network. Then, we applied the similarity network to the objective function as a graph regularization term. Finally, a proximal splitting algorithm was used to perform matrix completion to infer relationships between diseases and lncRNAs.

Results: In the experiment, DHOSGR achieves a superior performance in leave-one-out cross validation (LOOCV) and 100 times 5-fold cross validation (5-fold-CV), with AUC values of 0.9459 and 0.9334 ± 0.0016, respectively, which are better than other five previous models. Moreover, case studies of three diseases (leukemia, lymphoma, and squamous cell carcinoma) demonstrated that DHOSGR can reliably predict associated lncRNAs.

Conclusion: DHOSGR can serve as a high efficiency calculation model for predicting lncRNAdisease associations.

Keywords: lncRNA, decay high-order similarity, disease, lncRNA-disease associations, matrix completion, prediction.

Graphical Abstract
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