Abstract
Inspite of the various impediments in the bioavailability of orally delivered drugs, oral dosage forms, both solid and liquid, occupy a center stage in the therapeutic regimen of diseases. However, liquid dosage forms are more prone to low bioavailability because of their quick transit from the stomach/ duodenum. This could be a serious problem for drugs, which are absorbed from these sites of the GIT. The gastric retention of an oral liquid formulation could be successfully augmented substantially through a strategy of liquid in-situ gelling system. Natural polymers like alginate, gellan and chitosan can undergo sol to gel transformation in the presence of either divalent cations or due to a change in pH. The gel so formed, being lighter than gastric fluids, floats over the stomach contents and is retained there in for periods upto 24 hours. The in-situ gel formation enhances the local or systemic bioavailability of the administered drug. This concept is a redesign of liquid oral dosage form, which fulfills the requirement for a sustained release liquid preparation. This review discusses the various aspects associated with the in-situ gelling systems and their therapeutic applications.
Keywords: In-situ gel, phase transition, gastro-retentive, sodium alginate, gellan, pectin
Current Drug Delivery
Title: Phase Transition System: Novel Oral In-Situ Gel
Volume: 5 Issue: 4
Author(s): Ramesh C. Nagarwal and J. K. Pandit
Affiliation:
Keywords: In-situ gel, phase transition, gastro-retentive, sodium alginate, gellan, pectin
Abstract: Inspite of the various impediments in the bioavailability of orally delivered drugs, oral dosage forms, both solid and liquid, occupy a center stage in the therapeutic regimen of diseases. However, liquid dosage forms are more prone to low bioavailability because of their quick transit from the stomach/ duodenum. This could be a serious problem for drugs, which are absorbed from these sites of the GIT. The gastric retention of an oral liquid formulation could be successfully augmented substantially through a strategy of liquid in-situ gelling system. Natural polymers like alginate, gellan and chitosan can undergo sol to gel transformation in the presence of either divalent cations or due to a change in pH. The gel so formed, being lighter than gastric fluids, floats over the stomach contents and is retained there in for periods upto 24 hours. The in-situ gel formation enhances the local or systemic bioavailability of the administered drug. This concept is a redesign of liquid oral dosage form, which fulfills the requirement for a sustained release liquid preparation. This review discusses the various aspects associated with the in-situ gelling systems and their therapeutic applications.
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Cite this article as:
Nagarwal C. Ramesh and Pandit K. J., Phase Transition System: Novel Oral In-Situ Gel, Current Drug Delivery 2008; 5 (4) . https://dx.doi.org/10.2174/156720108785914952
DOI https://dx.doi.org/10.2174/156720108785914952 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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