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Current Bioactive Compounds


ISSN (Print): 1573-4072
ISSN (Online): 1875-6646

Research Article

Anti-cancer and Anti-venom Analysis of a Gedunin

Author(s): Priya Dagar and Abha Mishra*

Volume 19, Issue 5, 2023

Published on: 29 December, 2022

Article ID: e111022209811 Pages: 21

DOI: 10.2174/1573407218666221011092257

Price: $65


Background: A member of the Malvaceae family, Azadirachta indica (Neem) is wellknown for its secondary metabolites, including limonoids, flavonoids, triterpenoids, and tetraterpenoids. These compounds have been studied for decades for their bioactivities, including antihemorrhagic and antiproteolytic, which provide information about the use of triterpenoids.

Methods: Gedunin was purified by chromatography after being extracted using the Soxhlet method to ensure that it was present in the fruit of the (neem) A. indica plant. ICM Molsoft was used to test the substance for a potential inhibitory effect on the enzymes found in all species of snake venom, including 5'-nucleotidase, acetylcholinetrace, L-aao, metalloproteinase,

Results: Our goal is to forecast the pharmacological characteristics of gedunin, which has demonstrated a wide range of activities as a possible antidote for treating patients with snake bites. Our research also shows gedunin has some anti-cancer action in experiments using the cell line HepG2.

Conclusion: Gedunin has potential as a medication.

Keywords: Azadirachta indica, snake venom enzymes, pharmacological analysis, chemoinformatics, cell line, HepG2.

Graphical Abstract
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