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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Potential for Novel Therapeutic Uses of Alpha Lipoic Acid

Author(s): Babatunde Fasipe, Andre Faria and Ismail Laher*

Volume 30, Issue 35, 2023

Published on: 21 December, 2022

Page: [3942 - 3954] Pages: 13

DOI: 10.2174/0929867329666221006115329

Price: $65


Alpha-lipoic acid (ALA) is a potent antioxidant used in the management of diabetic neuropathy due to its ability to prevent neuronal lipid peroxidation. ALA also chelates transition metals, which can be beneficial in some diseases related to metal overload. Due to its unique antioxidant properties, ALA has potential novel applications in other diseases related to oxidative stress and inflammation. This review summarizes aspects of recent clinical trials and describes the uses of ALA in managing neuropathies. The unique pharmacological actions of ALA, coupled with relatively low toxicity, have led to several trials on the potential therapeutic uses of ALA in the management of diseases associated with increased oxidative stress, inflammation, and metal overload.

Keywords: Alpha lipoic acid, oxidative stress, inflammation, novel therapeutic use, lipid peroxidation, metal overload.

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