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Current Neuropharmacology


ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

Review Article

Potential Therapeutic Effects of Short-Chain Fatty Acids on Chronic Pain

Author(s): Yuanyuan Tang, Juan Du, Hongfeng Wu, Mengyao Wang, Sufang Liu* and Feng Tao*

Volume 22, Issue 2, 2024

Published on: 17 January, 2023

Page: [191 - 203] Pages: 13

DOI: 10.2174/1570159X20666220927092016

Price: $65


The intestinal homeostasis maintained by the gut microbiome and relevant metabolites is essential for health, and its disturbance leads to various intestinal or extraintestinal diseases. Recent studies suggest that gut microbiome-derived metabolites short-chain fatty acids (SCFAs) are involved in different neurological disorders (such as chronic pain). SCFAs are produced by bacterial fermentation of dietary fibers in the gut and contribute to multiple host processes, including gastrointestinal regulation, cardiovascular modulation, and neuroendocrine-immune homeostasis. Although SCFAs have been implicated in the modulation of chronic pain, the detailed mechanisms that underlie such roles of SCFAs remain to be further investigated. In this review, we summarize currently available research data regarding SCFAs as a potential therapeutic target for chronic pain treatment and discuss several possible mechanisms by which SCFAs modulate chronic pain.

Keywords: Short-chain fatty acids, chronic pain, gut microbiome, metabolites, gut-brain communication, intestinal diseases.

Graphical Abstract
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