Review Article

Gastrointestinal System: COVID-19 and Potential Mechanisms Associated with Coagulopathy

Author(s): Federica Furfaro, Roberto Gabbiadini, Ferdinando D’Amico, Alessandra Zilli, Arianna Dal Buono, Mariangela Allocca, Gionata Fiorino and Silvio Danese*

Volume 23, Issue 17, 2022

Published on: 13 October, 2022

Page: [1611 - 1619] Pages: 9

DOI: 10.2174/1389450123666220922095913

Price: $65


SARS-CoV-2 is a novel coronavirus that expanded worldwide, generating a pandemic of acute respiratory syndrome called “coronavirus disease 2019” (COVID-19), which resulted in a global health crisis. The spectrum of COVID-19 manifestations ranges from none or mild symptoms to severe respiratory failure associated with systemic manifestations, mostly gastrointestinal symptoms. Hypercoagulability is an important feature of COVID-19 disease, which can potentially influence patients’ prognosis. Therefore, gastroenterologists should focus on subjects with concomitant hypercoagulable gastrointestinal disorders as they may display a higher risk of thrombotic complications during SARS-CoV-2 infection. The aim of this review is to summarize the available evidence regarding the interplay of the prothrombotic pathogenetic mechanisms of both COVID-19 and hypercoagulable digestive diseases and the possible clinical implications. We summarized the potential interplay of prothrombotic mechanisms of both COVID-19 and hypercoagulable digestive diseases in the graphical abstract.

Keywords: Coronavirus disease 2019, SARS-CoV-2, hypercoagulable status, thromboembolism, inflammatory bowel disease, chronic liver disease, coeliac disease.

Graphical Abstract

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