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Current Indian Science


ISSN (Print): 2210-299X
ISSN (Online): 2210-3007

Review Article

A State-of-the-Art Review on Opioids Induced Constipation and its Management

Author(s): Suraj Longare, Dhwani Rana, Sagar Salave and Derajram Benival*

Volume 1, 2023

Published on: 02 September, 2022

Page: [1 - 17] Pages: 17

DOI: 10.2174/2210299X01666220902112122

open access plus


Background: Pain is a complex physiological and psychological response to a noxious stimulus, sometimes deteriorating a patient’s quality of life. Opioids remain the mainstay treatment modality for chronic pain. Several concerns are raised regarding the long-term use of opioids and the risks associated with their usage. Findings advocate that the longstanding practice of opioid consumption manifests in adverse effects. Objective: Due to the physiological changes opioids instigate in the gastrointestinal tract, opioid-induced constipation remains a common complication pragmatic in patients undergoing opioid medications. Several therapeutic interventions are made available, and the review describes the overall medications with practical examples, aiding in selecting a treatment plan.

Methods: The method comprises data collection from various search engines like PubMed, ScienceDirect, and SciFinder to get coverage of relevant literature for accumulating appropriate information regarding pain management, opioids, opioid-induced constipation, and its pharmacological interventions.

Results: The thoughtful custom of exploring several options to manage opioid-induced constipation must allow patients to benefit from opioid analgesia.

Conclusion: This paper reviews the role of opioids in pain management, the underlying mechanisms of their action, opioid-induced constipation, and pharmacological therapies, with experimental studies aiding clinicians to optimise treatment plans.

Keywords: Pain, Opioids, Opioid-induced constipation, Opioid receptors, Opioid inhibitors, Opioid antagonists.

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