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Current Molecular Pharmacology


ISSN (Print): 1874-4672
ISSN (Online): 1874-4702

Review Article

Effects of Modafinil (Provigil) on Memory and Learning in Experimental and Clinical Studies: From Molecular Mechanisms to Behaviour Molecular Mechanisms and Behavioural Effects

Author(s): Mohammad Yassin Zamanian, Mahdi Najafiani Karimvandi, Marjan Nikbakhtzadeh, Elham Zahedi, Dmitry Olegovich Bokov, Małgorzata Kujawska, Mahsa Heidari and Mohammad Reza Rahmani*

Volume 16, Issue 4, 2023

Published on: 16 November, 2022

Article ID: e010922208415 Pages: 10

DOI: 10.2174/1874467215666220901122824

Price: $65


Modafinil (MOD, 2‐diphenyl‐methyl‐sulphinil‐2‐acetamide) is a stimulant-like medicine used to treat narcolepsy. Off-label uses include improving cognitive ability in the course of other diseases. This review aims to discuss findings demonstrating the memory and learningenhancing activity of MOD in experimental and clinical studies. We included behavioral evaluations alongside the effects of MOD at the cellular and molecular level.

MOD in different animal disease models exerted beneficial effects on induced memory and learning impairment, which in some cases were accompanied by modulation of neurotransmitter pathways or neuroplastic capabilities, reducing oxidative stress, or expression of synaptic proteins. Individuals treated with MOD showed improved memory and learning skills in different conditions. These effects were associated with regulating brain activity in some participants, confirmed by functional magnetic resonance imaging.

Presented herein, data support the use of MOD in treating memory and learning deficits in various disease conditions.

Keywords: Modafinil, memory, learning, oxidative stress, hippocampus, synaptic plasticity.

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