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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

The Role of High-density Lipoprotein in Oral and Dental Diseases

Author(s): Leila Sadeghalbanaei, Farinaz Shirban, Mohammad Bagherniya*, Thozhukat Sathyapalan and Amirhossein Sahebkar*

Volume 30, Issue 20, 2023

Published on: 21 October, 2022

Page: [2226 - 2246] Pages: 21

DOI: 10.2174/0929867329666220901120654

Price: $65


High-density lipoprotein (HDL) is the smallest and densest of the lipoproteins. Beyond its well-known cardiovascular protective function, it has other actions, including structural function, anti-inflammatory, antioxidant, anti-thrombotic effects, transport of bioactive molecules, and induction of signal transduction pathways. Further, there is a mutual connection between oral health and general health. Hence HDL could be a potentially crucial factor relating oral health to general health. As far as we know, no comprehensive study has been carried out to date, which has explored the association between HDL concentration and oral diseases including lichen plan, recurrent aphthous ulcers, candidiasis, implant osseointegration, oral cancer and precancerous conditions. Here in this review, we summarized the relationship between HDL and oral health, suggesting a significant association between HDL concentration and oral health.

Keywords: HDL, oropharyngeal cancer, dental health, oral health, oral disease, dental disease.

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