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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Renal Effects of Empagliflozin in Patients with Type 2 Diabetes Mellitus

Author(s): Habib Yaribeygi, Mina Maleki, Thozhukat Sathyapalan*, Tannaz Jamialahmadi and Amirhossein Sahebkar*

Volume 30, Issue 25, 2023

Published on: 04 November, 2022

Page: [2850 - 2863] Pages: 14

DOI: 10.2174/0929867329666220831151645

Price: $65


Type 2 diabetes mellitus (T2DM) is one of the main causes of mortality and morbidity worldwide. It leads to various long-term complications such as diabetic nephropathy. Diabetes nephropathy is the leading cause of renal failure in patients with chronic kidney diseases undergoing hemodialysis. Hence preventing the development and progression of diabetic nephropathy is one of the main goals in the management of patients with type 2 diabetes. Sodium-glucose cotransporter 2 inhibitors of empagliflozin is a potent anti-hyperglycemic agents. In addition, it has been shown to have some pharmacologic potentials to provide renoprotective effects in patients with T2DM. In the current study, we review the available clinical data on the potential renoprotective effects of this drug from a mechanistic and molecular viewpoint.

Keywords: Type 2 diabetes mellitus, empagliflozin, sodium-glucose cotransporter 2 inhibitor, chronic kidney disease, diabetic nephropathy, renoprotective effects.

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