The Roles and Regulation of Ferroptosis in Cancer Progression

Title:The Roles and Regulation of Ferroptosis in Cancer Progression

Volume: 26 Issue: 6

Author(s): Yu yang, Te Ma, Ting Hu, Chengcheng Ma, Huiqing Tu and Shunqin Zhu*

Affiliation:

• School of Life Sciences, Southwest University, Beibei, Chongqing, 400716, China

Keywords: Ferroptosis, ROS, cancer progression, system Xc-, GPX4, cell death.

Abstract: Ferroptosis is an iron-dependent, nonapoptotic form of regulatory death and has received extensive attention. Fenton reaction related to iron metabolism release high levels of Reactive Oxygen Species (ROS), and the intracellular ROS content is closely related to various diseases; the iron ion concentration in many diseased cells is also disordered. In this paper, the advances in ferroptosis research are summarized, and the regulatory mechanisms of ferroptosis, including inducers and regulatory protein of ferroptosis in cancer progression. We expect that this study will benefit the further development of basic research and clinical application of ferroptosis for cancer treatment.

Cite this article as:

yang Yu, Ma Te, Hu Ting, Ma Chengcheng, Tu Huiqing and Zhu Shunqin*, The Roles and Regulation of Ferroptosis in Cancer Progression, Combinatorial Chemistry & High Throughput Screening 2023; 26(6) . https://dx.doi.org/10.2174/1386207325666220831151036