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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Adipose-Renal Axis in Diabetic Nephropathy

Author(s): Ming Yang, Panai Song, Li Zhao and Xi Wang*

Volume 30, Issue 16, 2023

Published on: 03 October, 2022

Page: [1860 - 1874] Pages: 15

DOI: 10.2174/0929867329666220806115518

Price: $65


Long-term diabetes can lead to renal injury known as diabetic nephropathy (DN), which is a major cause of end-stage renal disease (ESRD). However, its pathogenesis has not been well explained. Adipose tissue is recognized as an important energy storage device for the body. Interestingly, many studies have shown that adipose tissue can also act as an endocrine organ by secreting a variety of adipokines to maintain homeostasis. Here, we summarize some of the adipokines that have been identified so far to, more specifically, emphasize their role in DN progression and propose that the “adipose-renal axis” may be a potential target for treating DN.

Keywords: Diabetic nephropathy (DN), adipose tissues, adipokines, adiponectin, kidney, diabetes.

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