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Current Nanoscience


ISSN (Print): 1573-4137
ISSN (Online): 1875-6786

Mini-Review Article

Progress in the Detection of Cerebrospinal Fluid by Raman Spectroscopy

Author(s): Yali Song, Handan Bian, Tingting Zeng*, Ting Lin, Yuxin Liu, Shanying Deng, Juan Liao, Zhigang Mao and Si Chen

Volume 19, Issue 3, 2023

Published on: 09 September, 2022

Page: [338 - 349] Pages: 12

DOI: 10.2174/1573413718666220803141856

Price: $65


As a precious sterile body fluid, cerebrospinal fluid (CSF) examination plays an important role in the diagnosis of many clinical diseases. Early diagnosis can significantly improve these diseases' survival rate. Raman spectroscopy is a scattering spectrum that has been used for the research and analysis of molecular structures. It has been widely used in many fields, such as protein detection, tumor genes, microbiological pathogen compound materials, and food and medical monitoring, with high sensitivity and specificity. In this review, we briefly introduce the mechanism of Raman spectroscopy and summarize its progress in detecting cerebrospinal fluid, mainly focusing on the application of neurodegenerative diseases by Raman spectroscopy. Meanwhile, we also prospect the development of Raman spectroscopy in the detection of CSF and other fluids.

Keywords: Raman spectroscopy, cerebrospinal fluid, nanostructure, Alzheimer's disease, dopamine, neurodegeneration.

Graphical Abstract
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