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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Recent Development on Catalytic Reductive Amination and Applications

Author(s): Rama P. Tripathi, Shyam S. Verma, Jyoti Pandey and Vinod K. Tiwari

Volume 12, Issue 13, 2008

Page: [1093 - 1115] Pages: 23

DOI: 10.2174/138527208785740283

Price: $65


Reductive amination is one of the most useful and versatile methods for the preparation of amines in chemistry and biology. The present review focuses on the development of catalytic reductive amination from beginning to recent ones, where we have attempted to thoroughly illustrate an account of utility of various reagents including organocatalyst, symmetric and asymmetric (Ru, Rh, Ir) complexes, boron, tin or silicon reagents etc for enantio- and/or chemoselective reactions under different reaction conditions with emphasis on the yields of the reaction products and stability of the reagents used. Emerging applications of this reaction for the development of chiral ligands, pharmacologically active molecules, combinatorial scaffold, and key step in the total synthesis of some interesting natural products is also reviewed briefly.

Keywords: Reductive Amination, organocatalyst

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