Novel Targets for Antiinflammatory and Antiarthritic Agents

Title: Novel Targets for Antiinflammatory and Antiarthritic Agents

Volume: 12 Issue: 19

Author(s): R. G. Kulkarni, G. Achaiah and G. Narahari Sastry

Affiliation:

Keywords: Inflammation, IL-1, TNF-α, p38 Kinase, Matrix metalloproteinase

Abstract: Inflammation is a complex pathological condition associated with exaggerated human immune system involving various activated immune cells and bio-molecules. Treatment of inflammatory diseases perticularly chronic inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease etc. has been a big challenge for scientists as there are no safe drugs available for cure. Current therapeutic approaches to the treatment of inflammatory diseases are centered on cycloxygenase (both COX-1 and 2) proinflammatory enzymes but present available drugs of this category are associated with undesirable gastrointestinal and cardiovascular side effects. Recent scientific advents draw out the secrets of inflammation cache and understanding the involvement of several factors acting as stimulators or inhibitors thus opening new avenues for drug discoveries. Several bio-molecules such as proinflammatory cytokines, components of signal trasduction and matrix degrading enzymes resolve inflammatory responses, might be new targets for treatment of chronic inflammatory diseases. This review gathers recent advances in drug research focusing interleukin-1, TNF-α,p38 kinase, c-Jun N-terminal kinase MAP kinase, NFκB, and matrix metalloproteinases. The biological roles of these inflammatory mediators are clearly understood thus offering new targets for design of novel inhibitors for incurable inflammatory diseases. This also provides an overview of the current nonsteroidal antiinflammatory agents.

Cite this article as:

Kulkarni G. R., Achaiah G. and Narahari Sastry G., Novel Targets for Antiinflammatory and Antiarthritic Agents, Current Pharmaceutical Design 2006; 12 (19) . https://dx.doi.org/10.2174/138161206777698945