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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Polymeric Systems for Colon-specific Mesalazine Delivery in the Intestinal Bowel Diseases Management

Author(s): Alberto Gomes Tavares Junior, Jennifer Thayanne Cavalcante de Araújo, Jonatas Lobato Duarte, Amanda Letícia Polli Silvestre, Leonardo Delello Di Filippo and Marlus Chorilli*

Volume 30, Issue 12, 2023

Published on: 03 October, 2022

Page: [1351 - 1367] Pages: 17

DOI: 10.2174/0929867329666220707102912

Price: $65


The anti-inflammatory 5-aminosalicylic acid (5-ASA) is the main therapeutic option used to prevent and treat inflammatory bowel diseases. The upper intestinal tract performs rapid and almost complete absorption of this drug when administered orally, making local therapeutic levels of the molecule in the inflamed colonic mucosa difficult to achieve. Micro and nanoparticle systems are promising for 5-ASA incorporation because the reduced dimensions of these structures can improve the drug's pharmacodynamics and contribute to more efficient and localized therapy. Together, the association of these systems with polymers will allow the release of 5-ASA through specific targeting mechanisms to the colon, as demonstrated in the mesalazine modified-release dosage form. This review will summarize and discuss the challenges for the oral administration of 5-ASA and the different colon-specific delivery strategies using polymers.

Keywords: 5-ASA, polymeric systems, colonic delivery, nanoparticles systems, microparticles systems, modified- release dosage forms.

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