Generic placeholder image

Recent Patents on Anti-Cancer Drug Discovery


ISSN (Print): 1574-8928
ISSN (Online): 2212-3970

Mini-Review Article

Nanomaterials for Diagnosis and Treatment of Lung Cancer: A Review of Recent Patents

Author(s): Mandeep Kaur, Praveen Guleria and Vineet Kumar*

Volume 18, Issue 2, 2023

Published on: 27 September, 2022

Page: [114 - 124] Pages: 11

DOI: 10.2174/1574892817666220629104641

Price: $65


Background: Lung cancer is one of the major killers among different kinds of cancer. Being a silent developer, the earliest detection and treatment of lung cancer is a challenging task. The existing therapeutic agents have lower efficacy. Nanotechnology can overcome the challenges posed by conventional approaches to ensure reliable diagnosis and treatment.

Objectives: Various patents on nano diagnosis and nano delivery aspects of lung cancer were analyzed to compile the information in a nutshell. The increasing trend of patents on nano-based solutions for lung cancer opens new opportunities.

Methods: Google patent and Science Citation Index Expanded data sources were used to obtain relevant literature on nano-detection and nano-drug delivery for lung cancer. Various keywords were used to ensure the inclusion of recent and most relevant information in each section. The gist of the patent is described with suitable subsections.

Results: Thorough review of recent patents on nanotechnology-based theranostics of lung cancer was conducted. Nanotechnology-based diagnosis and treatment of lung cancer overcome the drawbacks of traditional treatments with better stability, targeted drug delivery, controlled sustained drug release, ease of membrane transport, and better therapeutic efficacy/safety ratio to obtain optimized clinical results. Further, it is cost-effective and accurate.

Conclusion: Overall, the application of nanotechnology in lung cancer treatment and diagnosis is a futuristic approach. Furthermore, NPs-based in vitro and in vivo detection and nano drug delivery to lungs need to be rigorously pursued for a sustainable solution.

Keywords: Nanosensor, nano drug delivery, nanoparticles, nanocarrier, nanocluster, slow and sustained release, nano diagnosis.

Cancer/tumor profiling market by (Technology (Immunoassay, NGS, PCR, In-Situ Hybridization, Microarray), cancer type (breast, lung, colorectal, prostate, melanoma)), biomarker type (genomic, protein), application, region - global forecast to 2025. 2020. Available from:
Reck M, Rodríguez-Abreu D, Robinson AG, et al. Pembrolizumab versus chemotherapy for PD-L1–positive non–small-cell lung cancer. N Engl J med 2016; 375: 1823-33.
[] [PMID: 27718847]
Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2020; 70(4): 313.
Yu Y, Mao L, Cheng Z, et al. A novel regQTL-SNP and the risk of lung cancer: A multi-dimensional study. Arch Toxicol 2021; 95(12): 3815-27.
[] [PMID: 34596730]
Gazdar AF, Bunn PA, Minna JD. Small-cell lung cancer: What we know, what we need to know and the path forward. Nat Rev Cancer 2017; 17(12): 725-37.
[] [PMID: 29077690]
Bahman F, Elkaissi S, Greish K, Taurin S. Polymeric micelles in management of lung cancer. In: Kesharwani P, Ed. Nanotechnology-based Targeted Drug Delivery Systems for Lung Cancer. Cambridge, Massachusetts: Academic Press 2019; pp. 193-216.
Norouzi M, Amerian M, Amerian M, et al. Clinical applications of nanomedicine in cancer therapy. Drug Discov Today 2020; 25(1): 107-25.
[] [PMID: 31586642]
MacDonald V. Chemotherapy: Managing side effects and safe handling. Can Vet J 2009; 50(6): 665-8.
[PMID: 19721789]
Thakur C. An overview, current challenges of drug resistance, and targeting metastasis associated with lung cancer. In: Kesharwani P, Ed. Nanotechnology-based Targeted Drug Delivery Systems for Lung Cancer. Cambridge, Massachusetts: Academic Press 2019; pp. 21-38.
Rai A, Comune M, Ferreira L. Nanoparticle-Based Drug Delivery Systems: Promising Approaches Against Bacterial Infections Inantibacterial Drug Discovery to Combat MDR. Singapore: Springer 2019; pp. 605-33.
Mu W, Chu Q, Liu Y, Zhang N. A review on nano-based drug delivery system for cancer chemoimmunotherapy. Nano-Micro Lett 2020; 12(1): 142.
[] [PMID: 34138136]
Zhao D, Liu Y, Crowe WN. Immunotherapeutic nanoparticles and methods relating thereto. WO Patent 2020210317A1, 2020.
Lin FH, Chang KJ, Tseng CL, et al. Pharmaceutical composition for inhalation delivery and fabrication method thereof. US Patent 12480626, 2010.
Amararathna M, Goralski K, Hoskin DW, Rupasinghe HV. Pulmonary nano-drug delivery systems for lung cancer: Current knowledge and prospects. J Lung Health Dis 2019; 3(2): 11-28.
Luo MX, Hua S, Shang QY. Application of nanotechnology in drug delivery systems for respiratory diseases. (Review). Mol Med Rep 2021; 23(5): 1-7.
[] [PMID: 33760125]
Günday Türeli N, Torge A, Juntke J, et al. Ciprofloxacin-loaded PLGA nanoparticles against cystic fibrosis P. aeruginosa lung infections. Eur J Pharm Biopharm 2017; 117: 363-71.
[] [PMID: 28476373]
Kim I, Byeon HJ, Kim TH, et al. Doxorubicin-loaded highly porous large PLGA microparticles as a sustained- release inhalation system for the treatment of metastatic lung cancer. Biomaterials 2012; 33(22): 5574-83.
[] [PMID: 22579235]
Zhong Q, Bielski ER, Rodrigues LS, Brown MR, Reineke JJ, da Rocha SR. Conjugation to poly (amidoamine) dendrimers and pulmonary delivery reduce cardiac accumulation and enhance antitumor activity of doxorubicin in lung metastasis. Mol Pharm 2016; 13(7): 2363-75.
[] [PMID: 27253493]
Wang J, Zhou T, Liu Y, Chen S, Yu Z. Application of nanoparticles in the treatment of lung cancer with emphasis on receptors. Front Pharmacol 2022; 12: 781425.
[] [PMID: 35082668]
Xu H, Wang Z, Xu P, et al. Mesoporous nano silicon ball compound targeting drug delivery system as well as preparation method and application thereof. CN Patent 104474555A, 2017.
Jeffry GW, Thomas T. Pulmonary delivery of a fluoroquinolone. CA Patent 2724009A, 2015.
Nikander KN, Von Hollen D, Scabeir EN. Method for aerosol drug delivery and apparatus comprising stepped mouthpiece. CN Patent 102264421B, 2011.
Gordon SM, Szidon JP, Krotoszynski BK, et al. Volatile organic compounds in exhaled air from patients with lung cancer. Clin Chem 1985; 31(8): 1278-82.
[] [PMID: 4017231]
Peng G, Tisch U, Adams O, et al. Diagnosing lung cancer in exhaled breath using gold nanoparticles. Nat Nanotechnol 2009; 4(10): 669-73.
[] [PMID: 19809459]
Chaturvedi VK, Singh A, Singh VK, et al. Cancer nanotechnology: A new revolution for cancer diagnosis and therapy. Curr Drug Metab 2019; 20(6): 416-29.
[] [PMID: 30227814]
Jin C, Wang K, Oppong-Gyebi A, et al. Application of nanotechnology in cancer diagnosis and therapy-a mini-review. Int J Med Sci 2020; 17(18): 2964.
[] [PMID: 33173417]
Emeje MO, Obidike IC, Akpabio EI, et al. Nanotechnology in drug delivery. Recent advances in novel drug carrier systems 2012; 10(31): 69-106.
Wang W, Hao Y, Liu Y, Li R, Huang DB, Pan YY. Nanomedicine in lung cancer: Current states of overcoming drug resistance and improving cancer immunotherapy. Wiley Interdiscip Rev Nanomed Nanobiotechnol 2021; 13(1): e1654.
[] [PMID: 32700465]
Mi P. Stimuli-responsive nanocarriers for drug delivery, tumor imaging, therapy and theranostics. Theranostics 2020; 10(10): 4557.
[] [PMID: 32292515]
Kim SJ, Choi SJ, Jang JS, et al. Innovative nanosensor for disease diagnosis. Acc Chem Res 2017; 50(7): 1587-96.
[] [PMID: 28481075]
Woodman C, Vundu G, George A, et al. Applications and strategies in nanodiagnosis and nanotherapy in lung cancer. Semin Cancer Biol 2020; 69: 349-64.
[] [PMID: 32088362]
Leng F, Liu F, Yang Y, Wu Y, Tian W. Strategies on nanodiagnostics and nanotherapies of the three common cancers. Nanomaterials (Basel) 2018; 8(4): 202.
[] [PMID: 29597315]
Yee Kuen C, Masarudin MJ. Chitosan nanoparticle-based System: A new insight into the promising controlled release system for lung cancer treatment. Molecules 2022; 27(2): 473.
[] [PMID: 35056788]
Shin TH, Choi Y, Kim S, Cheon J. Recent advances in magnetic nanoparticle-based multi-modal imaging. Chem Soc Rev 2015; 44(14): 4501-16.
[] [PMID: 25652670]
Munawar A, Ong Y, Schirhagl R, Tahir MA, Khan WS, Bajwa SZ. Nanosensors for diagnosis with optical, electric and mechanical transducers. RSC Adv 2019; 9(12): 6793-803.
Abdel-Karim R, Reda Y, Abdel-Fattah A. Nanostructured materials-based nanosensors. J Electrochem Soc 2020; 167(3): 037554.
Alexenko AG, Ananyan MA, Dshkhunyan VL, et al. Tunnel effect nanodetector of mechanical vibrations and method for preparation thereof. US Patent 6,829,941, 2004.
Khandare JJ, Banerjee S, Padigaru M, et al. Multifunctional magneto-polymeric nanosystems for rapid targeting, isolation, detection and simultaneous imaging of circulating tumor cells. US Patent 15/551,865, 2018.
De-Jun H, Wen-Fei C. Carbon nanotube sensor and production method. CN Patent 103592344A, 2014.
Guo X, Liu C, Deng A, et al. Analyzing chemical and biological substances using nano-structure based spectral sensing. US Patent 9,274,105, 2016.
Hong-Ju M, Chun-Ping J, Qing-Hui J, et al. Method for directly detecting P53 gene mutation in lung cancer sample based on nano probe. CN Patent 101392286B, 2011.
Gu LQ, Wang Y, Tian K, et al. Nanopore-facilitated single molecule detection of nucleic acids. US Patent 9,574,228, 2017.
Kostarelos K, Hadjidemetriou M. Detection of cancer biomarkers using nanoparticles. WO Patent 2018046542A1, 2018.
Zhengtang C, Jianguo S, Haizhen Z, et al. Preparation method for the chitosan molecule beacon nano-complex that the targeting octreotide of pulmonary cancer diagnosis is modified. CN Patent 104174035B, 2016.
Bradbury MS, Wiesner U, Medina OP, et al. Multimodal silica-based nanoparticles. US Patent 10,548,998, 2020.
Bradbury M, Wiesner U, Medina OP, Ow H. Fluorescent silica-based nanoparticles. US Patent 9,625,456, 2017.
Chun-Ping J, Feng-Xiang J, Hui Z, et al. A kind of high-sensitivity detecting method of the multiple lung cancer marker based on nm of gold enhancing. CN Patent 102313814B, 2016.
Xin Z, Xiaowei M, Shi-Zhen C, et al. RGD-graphene / MnO2 composite probe of magnetic nanosphere and application thereof. CN Patent 107080850B, 2020.
Qin W, Dan W, Aiping G, et al. Preparation and application of Au-Pd core-shell material constructed lung cancer tumor marker immunosensor. CN Patent 102818893B, 2013.
Qian X, Ansari D, Nie S, et al. Vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags. US Patent 10,137,208, 2018.
Fu A, Wang SX, Gambhir SS, et al. Fluorescent magnetic nanoprobes, methods of making, and methods of use. US Patent 15/164,066, 2016.
Bhatia SN, Kirkpatrick J, Dudani JS, et al. Lung protease nanosensors and uses thereof. US Patent 16/582,053, 2020.
Bossmann SH, Troyer DL, Basel MT. Diagnostic assays for detecting protease activity associated with cancer. CA Patent 2717563C, 2017.
Lapotko DO, Hleb K. Diagnosis, removal, or mechanical damaging of tumor using plasmonic nanobubbles. US Patent 10,471,159, 2019.
Wang H, Guo X. Detecting chemical and biological impurities by nano-structure based spectral sensing. US Patent 8,081,308, 2011.
Haick H, Gang P, Adams O, et al. Detection of cancer through breath comprising a sensor array comprising capped conductive nanoparticles. US Patent 9,696,311, 2017.
Haick H, Peled N. Breath analysis of pulmonary nodules. US Patent 9,528,979, 2016.
Gabriel JC, Joshi V, Niemann J, et al. Nanoelectronic breath analyzer and asthma monitor. US Patent 11/437,275, 2007.
Shehada N, Cancilla JC, Torrecilla JS, et al. Silicon nanowire sensors enable diagnosis of patients via exhaled breath. ACS nano 2016; 10(7): 7047-57.
[] [PMID: 27383408]
Kim ID, Koo W, Jang J, et al. Porous semiconductor metal oxide complex nanofibers including nanoparticle catalyst functionalized by nano-catalyst included within metal-organic framework, gas sensor and member using the same, and method of manufacturing the same. US Patent 10,533,987, 2020.
Haick H. Volatile organic compounds as diagnostic markers in the breath for lung cancer. US Patent 8,597,953, 2013.
Gouma IP, Rigas A. Selective point of care nanoprobe breath analyzer. US Patent 14/334,336, 2014.
Longest PW, Hindle M. Delivery of submicrometer and nanometer aerosols to the lungs using hygroscopic excipients or dual stream nasal delivery. US Patent 9,433,588, 2016.
Zale SE, Ali MM. Cancer cell targeting using nanoparticles. US Patent 8,246,968, 2012.
Zale SE, Troiano G, Ali MM, et al. Long circulating nanoparticles for sustained release of therapeutic agents. US Patent 9,198,874, 2015.
Graham D, Wheate NJ. Nanoparticle for biomolecule delivery. WO Patent 2010139942A2, 2011.
Markovic SN, Nevala WK. Methods of using albumin-antibody nanoparticle complex compositions for treating cancer. US Patent 10,596,112, 2020.
Figuered DM, Davidson J-H. Therapeutic polymer nanoparticle containing epothilone and methods of making and using the same. JP Patent 5898627B2, 2016.
Fill-Feng C, Liang-Ping L, Chang-Chang S, et al. A kind of magnetic resonance imaging nano-carrier, nano medicament carrying system and preparation method thereof. CN Patent 108404142A, 2020.
Zhu L, Torchilin V. System for co-delivery of polynucleotides and drugs into protease-expressing cells. US Patent 15/033,996, 2016.
Kwong KF, Tobin LA. Nanoparticles with enhanced entry into cancer cells. WO Patent 2013173693, 2013.
Juanshu L, Ruixia Z, Guangji W. Preparation and application of hyaluronic acid-antitumor drug conjugate and composite nanoparticle composition. CN Patent 103751795A, 2017.
Jinjun L, Weiyi S, Qiangbay L. Nano-silver anti-cancer composition for treating lung cancer as well as preparation method and application thereof. CN Patent 103933067, 2015.
Kumar A, Mohapatra SS, Cameron DF, et al. Nanoparticle targeted drug delivery to the lungs using extra-testicular sertoli cells. US Patent 16/154,922, 2019.
John C, Unger G. Biologic modulations with nanoparticles. US Patent 10/409,786, 2004.
Chun-Lei L, Yan-Hui L, Min L, et al. Purified therapeutic nanoparticles and method of making same. CN Patent 106687110B, 2015.
Feng L. Plant anti-cancer targeting nano-preparation, and preparation method thereof. CN Patent 102688200B, 2014.
Iglesias R, Koria P. Cargo carrying nanoparticles. US Patent 9,616,138, 2017.
Liversidge G, Jenkins S, Liversidge E, et al. Nanoparticulate formulations of docetaxel and analogues thereof. US Patent 11/361,055, 2006.
Jingwei S, Pengyu W, Bingchen Z, Min Z. A kind of preparation method and applications of the self-assembled nanometer grain with target function. CN Patent 109513011A, 2019.
Zhipeng L, Ya-qin L, Ming-Zheng W. Application of hyaluronic acid nanoparticles in preparation of medicine for treating lymphatic system tumor. CN Patent 106237340B, 2020.
Grimm J, Kaittanis C, Shaffer TM, et al. Compositions and methods for nanoparticle-based drug delivery and imaging. US Patent 16/659,343, 2020.
Yang DC, Kim YJ, Priyanka S, et al. Nano complex comprising a nano drug delivery matrix; And a ginseng extract or a ginsenoside isolated therefrom. US Patent 10,912,737, 2021.
Yan H, Wen-Jing W, Kun Z, et al. A kind of based on biological functionalized nano silver paclitaxel loaded or the targeted delivery systems of its analog. CN Patent 106265598A, 2017.
Mousa SA, Hay BA. Composition of scalable thyrointegrin antagonists with improved blood brain barrier penetration and retention into brain tumors. US Patent 10,961,204, 2021.
Sengupta G, Kyle A, Sony G. Nano level platinic compound and using method thereof. CN Patent 102388073B, 2015.
Nel AE, Meng H, Liu X, et al. Mesoporous silica nanoparticles with a lipid bilayer coating for cargo delivery. US Patent 10,765,636, 2020.
Nel AE, Meng H, Liu X, et al. Mesoporous silica nanoparticles with lipid bilayer coating for cargo delivery. US Patent 10,143,660, 2018.
McGhee W, Blackledge J, Grapperhaus M, et al. Modified docetaxel liposome formulations. US Patent 14/208,324, 2014.
Nowotnik DP, Zarzycki R, Sood P, et al. Targeted nanocarrier systems for delivery of actives across biological membranes. US Patent 14/804,168, 2016.
Ho D, Chen M, Pierstorff E, et al. Northwestern University, assignee. Nanodiamond particle complexes US Patent 12/789,966, 2010.
Luo Y. Monosaccharide-tagged nano-liposome drug delivery system, the manufacture and use for drug targeting delivery thereof. TW Patent 202042788A, 2020.
Yanhua L, Tong Y, Lan SY, et al. A kind of double prodrugs are total to assemble nanometer targeting drug delivery system and preparation method thereof. CN Patent 109939241A, 2019.
Aizheng C, Shibin W, Hufan S, et al. Method for preparing gene and polypeptide drug loaded micro-nano porous microsphere by supercritical fluid technology. CN Patent 105963714B, 2019.
Cheng KW, Hui KC, Kong CT. Nanoparticle delivery system. WO Patent 2020114390A1, 2020.
Zeineldin R. Intraperitoneally-administered nanocarriers that release their therapeutic load based on the inflammatory environment of cancers. US Patent 9,532,949, 2017.
Jinjun L, Weiyi S, Qiangbay L. Nano-silver anti-cancer composition for treating lung cancer as well as preparation method and application thereof. US Patent 103933067, 2014.
Liu K, Gong F, Xu H, et al. Amphiphilic block copolymer and preparation method thereof and micellar drug-loading system formed by same with antitumor drug. US Patent 9,393,312, 2016.
Weicheng H, Jianmei Z, Yijun W, et al. A kind of preparation method of Ginsenoside compound K-chitosan micelle nanoparticle. CN Patent 108553647B, 2019.
Berkland CJ, Shi L. Nanoclusters compositions and methods. US Patent 9,278,069, 2016.
Wei Z, Weihua L, Fan L. Drug delivery system of targeting beta-cyclodextrin grafted chitosan ion cross-linked nanoparticles and preparation method and application thereof. CN Patent 108721251B, 2020.
Nel AE, Zink JI, Meng H. Lipid bilayer coated mesoporous silica nanoparticles with a high loading capacity for one or more anticancer agents. US Patent 16/948,498, 2021.
Zink JI, Nel AE, Xia T, Ji Z. Cationic polymer coated mesoporous silica nanoparticles and uses thereof. US Patent 13/428,830, 2012.
Xu T, Dong H, Shu J, Dube N, et al. Bis-polymer lipid-peptide conjugates and nanoparticles thereof. US Patent 10,806,702, 2020.
Weicheng H, Jianmei Z, Yi W. A kind of preparation method of Ginsenoside compound K-chitosan micelle nanoparticle. CN Patent 112426535A, 2019.
Weng KC, Chen FF, Gray JW, et al. Targeted nanoclusters and methods of their use. US Patent 13/500,859, 2012.
Berkland CJ, Bailey M, Gendy NE, et al. Nanoclusters for delivery of poorly water soluble drug nanoparticles. WO Patent 2010009146A1, 2010.
Tao C, Desai NP, Soon-Shiong P, et al. Combination therapy with nanoparticle compositions of taxane and hedgehog inhibitors. US Patent 13/781,487, 2014.

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy