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Current Cancer Drug Targets


ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

Role of TGF- β in the Tumor Stroma

Author(s): H. P.H. Naber, P. ten Dijke and E. Pardali

Volume 8 , Issue 6 , 2008

Page: [466 - 472] Pages: 7

DOI: 10.2174/156800908785699342

Price: $65


Recent findings have demonstrated that the tumor stroma actively contributes to tumorigenesis. The communication of malignant cells and tumor stromal components is orchestrated in part by a network of growth factors. One of these growth factors is transforming growth factor-β (TGF-β), a secreted multifunctional protein that acts in a highly cellular contextual manner. TGF-β can either stimulate or inhibit the tumor-promoting effects of the different components of the tumor stroma. In this review, we discuss our current understanding on how TGF-β influences different stromal compartments.

Keywords: TGF-β, tumor stroma, CAF, angiogenesis, immune cells

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