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Reviews on Recent Clinical Trials

Editor-in-Chief

ISSN (Print): 1574-8871
ISSN (Online): 1876-1038

Systematic Review Article

Traumatic Brain Injury and Gut Brain Axis: The Disruption of an Alliance

Author(s): Michela Ferrara, Giuseppe Bertozzi*, Christian Zanza, Yaroslava Longhitano, Fabio Piccolella, Cristiano Ernesto Lauritano, Gianpietro Volonnino, Alice Chiara Manetti, Aniello Maiese and Raffaele La Russa

Volume 17, Issue 4, 2022

Published on: 21 October, 2022

Page: [268 - 279] Pages: 12

DOI: 10.2174/1574887117666220622143423

Abstract

Background: Traumatic brain injury (TBI) can be considered a "silent epidemic", causing morbidity, disability, and mortality in all age cohorts. Therefore, a greater understanding of the underlying pathophysiological intricate mechanisms and interactions with other organs and systems is necessary to intervene not only in the treatment but also in the prevention of complications. In this complex of reciprocal interactions, the complex brain-gut axis has captured a growing interest.

Scope: The purpose of this manuscript is to examine and systematize existing evidence regarding the pathophysiological processes that occur following TBI and the influences exerted on these by the brain-gut axis.

Literature Review: A systematic review of the literature was conducted according to the PRISMA methodology. On the 8th of October 2021, two independent databases were searched: PubMed and Scopus. Following the inclusion and exclusion criteria selected, 24 (12 from PubMed and 12 from Scopus) eligible manuscripts were included in the present review. Moreover, references from the selected articles were also updated following the criteria mentioned above, yielding 91 included manuscripts.

Discussion: Published evidence suggests that the brain and gut are mutually influenced through four main pathways: microbiota, inflammatory, nervous, and endocrine.

Conclusion: These pathways are bidirectional and interact with each other. However, the studies conducted so far mainly involve animals. An autopsy methodological approach to corpses affected by traumatic brain injury or intestinal pathology could represent the keystone for future studies to clarify the complex pathophysiological processes underlying the interaction between these two main systems.

Keywords: Traumatic brain injury, gut-brain axis, dysbiosis, dysautonomia, neuroinflammation, microbiota.

Graphical Abstract
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