Generic placeholder image

The Natural Products Journal

Editor-in-Chief

ISSN (Print): 2210-3155
ISSN (Online): 2210-3163

Review Article

Phytochemistry and Medicinal Importance of Herb Mimosa pudica: A Review

Author(s): Venzil W. Fernandes, Santosh L. Gaonkar* and Nitinkumar S. Shetty

Volume 13, Issue 4, 2023

Published on: 21 October, 2022

Article ID: e170622206126 Pages: 22

DOI: 10.2174/2210315512666220617112442

Price: $65

Abstract

Background: Mimosa pudica is a tropical weed that belongs to the legume family and is native to South America. This plant is also found in different regions of India, such as Andhra Pradesh, Telangana, Karnataka, Kerala, Orissa, and Tamil Nadu. It is a known plant that can show thigmonasty. The plant possesses diverse biological properties, including antimicrobial, antidiabetic, anticonvulsant, antivenom, anti-inflammatory, antitumor, antifungal, antinociceptive, and antiulcer activity, and has an antioxidant and antifertility effect, antihistamine, wound healing, diuretic effect, etc. The herb is traditionally used for ages to treat urogenital disorders, dysentery, sinus piles, and wound healing.

Objective: Review stresses on plant movement displayed by the plant Mimosa pudica and the responsible phytocompounds. The bioactive compounds isolated by various researchers to date and the pharmacological activities displayed by the plant are thoroughly reviewed.

Methods: The literature related to phytochemical and pharmacological studies has been collected from various databases such as Scopus, PubMed, various student papers, publications, and internet sources from 1877 to 2021.

Results: The net result of the study showed that Mimosa pudica possesses various phytochemicals responsible for plant movement and pharmacological activities that are further proven through computational studies. Further, nanoparticles and hydrogels from Mimosa pudica have been studied for their various applications in recent years.

Conclusion: The herb seems to be a promising natural medicine to undergo further investigation, as evidenced by its diverse biological profile.

Keywords: Mimosine, Mimosa pudica, nastic movement, natural medicine, phytochemistry, thigmonasty.

Graphical Abstract
[1]
Genest, S.; Kerr, C.; Shah, A.; Rahman, M.M.; Saif-E-Naser, G.M.M.; Nigam, P.; Nahar, L.; Sarker, S.D. Comparative bioactivity studies on two mimosa species. Bol. Latinoam. Caribe Plantas Med. Aromat., 2008, 7(1), 38-43.
[2]
Vishnupriya, S.; Somasundaram, S. In silico and in-vitro study of Mimosa pudica and the bactericidal activity of its phytocompound mimosine against methicillin-resistant Staphylococcus aureus (MRSA). Int. J. Curr. Eng. Sci. Res, 2016, 3(11), 14-25. [IJCESR
[3]
Factsheet-Mimosa pudica (Common Sensitive Plant). Available from: https://keys.lucidcentral.org/keys/v3/eafrinet/weeds/key/weeds/Media /Html/ (accessed Apr 18, 2021).
[4]
Fondeville, J.C.; Schneider, M.J.; Borthwick, H.A.; Hendricks, S.B. Photocontrol of Mimosa pudica L. leaf movement. Planta, 1967, 75(3), 228-238.
[http://dx.doi.org/10.1007/BF00386322] [PMID: 24549306]
[5]
Goyal, S. How many types of Nastic movements occur in plants? Available from: https://www.jagranjosh.com/general-knowledge/what-is-nasticmovement- in-plants-1516350600-1 (accessed Feb 18, 2021).
[6]
Messrs; Longmans, T. Text-Book of Botany; Nature Publishing Group, 1877, pp. 348-350.
[7]
Schildknecht, B.H. Turgorins, hormones of the endogeneous daily rhythms of higher organized plants- detection, isolation, structure, synthesis, and activity. Angew. Chem. Int. Ed. Engl., 1983, 22(9), 695-710.
[http://dx.doi.org/10.1002/anie.198306951]
[8]
Johnson, K.; Narasimhan, G.; Krishnan, C. Mimosa pudica Lnn.- a shyness princess: A review of its plant mo active constituents, uses and pharmacological activity. Int. J. Pharm. Sci. Res., 2021, 5(12), 1-8.
[http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5104-18]
[9]
Williams, C.N.; Raghavan, V. Effects of aflets of Mimosa pudica. J. Exp. Bot., 1966, 17(4), 742-749.
[http://dx.doi.org/10.1093/jxb/17.4.742]
[10]
Fondeville, J.C.; Borthwick, H.A.; Hendricks, S.B. Leaflet movement of Mimosa pudica L. Indicative of phytochrome action. Planta, 1966, 69(4), 357-364.
[http://dx.doi.org/10.1007/BF00392286] [PMID: 24557886]
[11]
Toriyama, H. Observational and experimental studies of sensitive plants Catologia, 1962, 27(3), 276-284.
[12]
Bose, D.M. An ATPase in sensitive Mimosa pudica I. Purif. Charat., 1972, 148(1), 199-207.
[13]
Volkov, A.G.; Foster, J.C.; Ashby, T.A.; Walker, R.K.; Johnson, J.A.; Markin, V.S. Mimosa pudica: Electrical and mechanical stimulation of plant movements Plant Cell Environ., 2010, 33(2), 163-173.
[http://dx.doi.org/10.1111/j.1365-3040.2009.02066.x] [PMID: 19895396]
[14]
Abe, T. Chloride ion efflux during an action potential in the main pulvinus of Mimosa pudica. Bot. Mag: Bot. Mag. Tokyo, 1981, 94(4), 379-383.
[http://dx.doi.org/10.1007/BF02493398]
[15]
Roblin, G.; Fleurat-Lessard, P. Redistribution of potassium, chloride and calcium during the gravitropically induced movement of Mimosa pudica pulvinus. Planta, 1987, 170(2), 242-248.
[http://dx.doi.org/10.1007/BF00397894] [PMID: 24232884]
[16]
Fleurat-Lessard, P.; Bouche-Pillon, S.; Leloup, C.; Bonnemain, J.L. Distribution and activity of the plasma membrane H+-ATPase in Mimosa pudica L. in relation to ionic fluxes and leaf movements. Plant Physiol., 1997, 113(3), 747-754.
[http://dx.doi.org/10.1104/pp.113.3.747] [PMID: 12223640]
[17]
Tran, D.; Petitjean, H.; Chebli, Y.; Geitmann, A.; Sharif-Naeini, R. Mechanosensitive ion channels contribute to mechanically evoked rapid leaflet movement in Mimosa pudica. Plant Physiol., 2021, 187(3), 1704-1712.
[http://dx.doi.org/10.1093/plphys/kiab333] [PMID: 34734277]
[18]
Bamola, N.; Verma, P.; Negi, C. Review on some traditional medicinal plants. Int. J. Life Sci. Res, 2018, 4(1), 1550-1556.
[19]
Ganguly, M.; Devi, N.; Mahanta, R.; Borthakur, M.K. Effect of Mimosa pudica root extract on vaginal estrous and serum hormones for screening of antifertility activity in albino mice. Contraception, 2007, 76(6), 482-485.
[http://dx.doi.org/10.1016/j.contraception.2007.08.008] [PMID: 18061708]
[20]
Muthumani, P.; Meera, R.; Devi, P.; Koduri, L.V.S.K.; Manavarthi, S.; Badmanaban, R. Phytochemical investigation and enzyme inhibitory activity of Mimosa pudica Lnn. J. Chem. Pharm. Res., 2010, 2(5), 108-114.
[21]
Pande, M.; Pathak, A. Preliminary pharmacognostic evaluations and phytochemical studies on roots of Mimosa pudica (lajvanti). Inter. J. Pharm. Sci. Rev. Res., 2010, 1
[22]
Kaur, P.; Kumar, N.; Shivananda, T.N.; Kaur, G. Phytochemical screening and antimicrobial activity of the plant extracts of Mimosa pudica L. against selected microbes. J. Med. Plants Res., 2011, 5(22), 5356-5359.
[23]
Tamilarasi, T.; Ananthi, T. Phytochemical analysis and anti microbial activity of Mimosa pudica Lnn. Res. J. Chem. Sci., 2012, 2(2), 72-74.
[24]
Rajan, R.; Manoharan, S.; Seethalakshmi, K.R. Phytochemical analysis of leaves and roots of Mimosa pudica collected from Kalingavaram, Tamil Nadu. J. Chem. Pharm. Res., 2013, 5(5), 53-55.
[25]
Sandhya, M.M.; Bhawana, P.; Sunita, G.R. Phytochemical analysis and uses of Mimosa pudica Lnn. in Chhattisgarh. J. Environ. Sci. Toxicol. Food Technol., 2015, 1(3), 1-4.
[26]
Chinnathambi, A.; Sathasivam, A. Analysis of the phytochemical constituents of Mimosa pudica and determination of their antimicrobial activity. J. Biotechnol. Biomater., 2015, 5(2) Available from:
[http://dx.doi.org/10.4172/2155-952X.S1.031]
[27]
Amengialue, O.O.; Oviasogie, E.F. Phytochemical screening and assessment of antimicrobial activity of Mimosa pudica. Eur. Virtual Conf. Nat. Appl. Sci., 2016, 1, 1-10.
[28]
Racadio, S.P. The medicinal prospects of makahiya (Mimosa pudica Lnn.) plant. Adv. Life Sci., 2016, 6(1), 7-12.
[http://dx.doi.org/10.5923/j.als.20160601.02]
[29]
Mathew, J.J.; Vazhacharickal, P.J.; Joy, J.K. Phytochemical analysis and in vitro hemostatic activity of Mimosa pudica, Hemigraphis colorata and Chromolaena odorata leaf extracts. CIBTech. J. Pharm. Sci., 2016, 5(3), 16-34.
[30]
Surquia, J.; Racadio, S.P.; Molina, G.V.; Tacla, R. Phytochemical and microbiological testing of Makahiya (Mimosa pudica Lnn.) leaf extract. UNP Res. J., 2018, XVII, 11-18.
[31]
Chandran, R.P.; Deepa, V.; Krishna, S.; Fathima, S.; Thaha, A.; Raj, J. Analysis of phytochemical constituents and anthelmintic activity of leaf extracts of Mimosa pudica L. Asian J. Biomed. Pharm. Sci., 2018, 8(65) Available from: https://www.alliedacademies.org/articles/analysis-of-phytochemicalconstituents- and-anthelmintic-activity-of-leaf-extracts-of-mimosapudica- l-10260.html
[http://dx.doi.org/10.4066/2249-622X.65.18-614]
[32]
Malathy, D. Cytotoxicity and antimicrobial activities of copper nanoparticles synthesised using Mimosa pudica. Res. J. Pharm. Technol., 2019, 12(9), 4359-4364.
[http://dx.doi.org/10.5958/0974-360X.2019.00750.9]
[33]
Dhanya, K.G.; Thangavel, M. Mimosine-A novel substance and evaluate the lipid peroxidation. Asian J. Pharm. Clin. Res., 2019, 12(3), 57-60.
[http://dx.doi.org/10.22159/ajpcr.2019.v12i3.22812]
[34]
Kowsalya, R.; Sangeetha, K.A. Hepatoprotective activity of ethyl acetate of Mimosa pudica leaves against paracetamol induced in albino wister rats. Plant Arch., 2020, 20, 2006-2011.
[35]
Kleipool, R.J.C.; Wibaut, J.P. Mimosine (Leucaenine) 5th Communication. Recl. Trav. Chim. Pays Bas, 1950, 69(1), 37-44.
[http://dx.doi.org/10.1002/recl.19500690106]
[36]
Tiwari, H.P.; Spenser, I.D. Precursors of mimosine in Mimosa pudica. Can. J. Biochem., 1965, 43(10), 1687-1691.
[http://dx.doi.org/10.1139/o65-186] [PMID: 5864482]
[37]
Tiwari, H.P.; Penrose, W.R.; Spenser, I.D. Biosynthesis of mimosine: Incorporation of serine and of α-aminoadipic acid. Phytochemistry, 1967, 6(9), 1245-1248.
[http://dx.doi.org/10.1016/S0031-9422(00)86087-2]
[38]
Nair, L.S.; Menon, S.N.; Shailajan, S.; Baing, M.M.; Sane, R.T. Reversed-phase high-performance thin-layer chromatographic quantification of mimosine from whole plant of Mimosa pudica Lnn. J. Planar Chromatogr. Mod. TLC, 2007, 20(1), 49-51.
[http://dx.doi.org/10.1556/JPC.20.2007.1.7]
[39]
Murakoshi, I.; Kuramoto, H.; Ohmiya, S.; Haginiwa, J. Enzymic synthesis of mimoside: A metabolite of mimosine in Mimosa pudica and Leucaena leucocephala. Chem. Pharm. Bull. (Tokyo), 1972, 20(4), 855-857.
[http://dx.doi.org/10.1248/cpb.20.855]
[40]
Tahara, A.; Nakata, T.; Ohtsuka, Y.; Takada, S. Mimoside: A Glucosidic metabolite of mimosine in Mimosa pudica and Leucaena leucocephala. Chem. Pharm. Bull. (Tokyo), 1971, 19(12), 2655-2657.
[http://dx.doi.org/10.1248/cpb.19.2655]
[41]
Schildknecht, H.; Iyengar, D.S.P. On the biological chemistry of mimosaceae I D-Pinitol from Mimosa pudica L. Naturwissenschaften, 1975, 62(11), 533-534.
[http://dx.doi.org/10.1007/BF00609073] [PMID: 814472]
[42]
Jiang, Y.; Haag, M.; Quirion, J.; Cabalion, P.; Kuballa, B.; Anton, R. Structure of a new saponin from the seed of Mimosa pudica In: Laboratoire de Pharmacognoise; France, 1990; 56, p. 555.
[43]
Ueda, M.; Yamamura, S. The chemistry of leaf-movement in Mimosa pudica L. Tetrahedron, 1999, 55(36), 10937-10948.
[http://dx.doi.org/10.1016/S0040-4020(99)00619-5]
[44]
Mahanta, M.; Mukherjee, A.K. Neutralisation of lethality, myotoxicity and toxic enzymes of Naja kaouthia venom by Mimosa pudica root extracts. J. Ethnopharmacol., 2001, 75(1), 55-60.
[http://dx.doi.org/10.1016/S0378-8741(00)00373-1] [PMID: 11282444]
[45]
Yusuf, U.K.; Abdullah, N.; Bakar, B.; Itam, K.; Abdullah, F.; Sukari, M.A. Flavonoid glycosides in the leaves of mimosa Species. Biochem. Syst. Ecol., 2003, 31(4), 443-445.
[http://dx.doi.org/10.1016/S0305-1978(02)00171-0]
[46]
Yuan, K.; Lü, J.L.; Yin, M.W.; Zhu, J.X. Chemical constituents of Cglycosylflavones from Mimosa pudica. Yao Xue Xue Bao, 2006, 41(5), 435-438.
[PMID: 16848320]
[47]
Yuan, K.; Lu, J.L.; Jia, A.; Zhu, J.X. Studies on chemical constituents of Mimosa pudica. Available from: https://www.researchgate.net/publication/279620194_Studies_on_che mical_constituents_of_Mimosa_pudica (accessed Mar 4, 2021).
[48]
Yuan, K.; Lu, J.L.; Jia, A.; Zhu, J.X. Two New C-Glycosylflavones from Mimosa pudica. Chin. Chem. Lett., 2007, 18(10), 1231-1234.
[http://dx.doi.org/10.1016/j.cclet.2007.08.008]
[49]
Kashmira, J.G.; Mayuri, A.L.; Varsha, M.S. A comprehensive review on ‘Mimosa pudica’: A potential herbal panacea. J. Biol. Act. Prod. from Nat., 2011, 1(5-6), 285-292.
[http://dx.doi.org/10.1080/22311866.2011.10719096]
[50]
Champanerkar, P.A.; Vaidya, V.V.; Kekare, M.B. Chromatographic techniques for quantification of sterol from Mimosa pudica Lnn. whole plant powder. Anal. Chem. an Indian J., 2010, 9(2), 242-246.
[51]
Saraswat, R.; Pokharkar, R. GCMS Studies of Mimosa pudica. Int. J. Pharm. Tech. Res., 2012, 4(1), 93-98.
[52]
Sanaye, M.M.; Joglekar, C.S. Mimosa-a brief overview. J. Pharmacogn. Phytochem. JPP, 2015, 182(42), 182-187.
[53]
Jose, J.; Dhanya, A.T.; Haridas, K.R.; Sumesh Kumar, T.M.; Jayaraman, S.; Variyar, E.J.; Sudhakaran, S. Structural characterization of a novel derivative of myricetin from Mimosa pudica as an anti-proliferative agent for the treatment of cancer. Biomed. Pharmacother., 2016, 84, 1067-1077.
[http://dx.doi.org/10.1016/j.biopha.2016.10.020] [PMID: 27780135]
[54]
Sanaye, M.M.; Joglekar, C.S. HPTLC identification, quantification and validation of p-coumaric acid and quercetin in aqueous extract of Mimosa pudica. Int. J. Pharmacogn. Phytochem. Res., 2015, 7(4), 839-843.
[55]
Rathnamali, A. A review on Mimosa pudica plant. Int. J. Adv. Res. Rev., 2019, 4(11), 20-27.
[56]
Anselm, A.A.; Okoronkwo, J.C. JohnBull, O.E. Secondary metabolites from Mimosa pudica: Isolation. purification and NMR characterization. J. Appl. Chem., 2017, 10(3), 15-20.
[http://dx.doi.org/10.9790/5736-1003011520]
[57]
Tunna, T.S.; Sarker, M.Z.I.; Ghafoor, K.; Ferdosh, S.; Jaffri, J.M.; Al-Juhaimi, F.Y.; Ali, M.E.; Akanda, M.J.H.; Awal, M.S.; Ahmed, Q.U.; Selamat, J. Enrichment, in vitro, and quantification study of antidiabetic compounds from neglected weed Mimosa pudica using supercritical CO2 and CO2-soxhlet. Sep. Sci. Technol., 2018, 53(2), 243-260.
[http://dx.doi.org/10.1080/01496395.2017.1384015]
[58]
Tasnuva, S.T.; Qamar, U.A.; Ghafoor, K.; Sahena, F.; Jahurul, M.H.A.; Rukshana, A.H.; Juliana, M.J.; Al-Juhaimi, F.Y.; Jalifah, L.; Jalal, K.C.A.; Ali, M.E.; Zaidul, I.S.M. α-glucosidase inhibitors isolated from Mimosa pudica L. Nat. Prod. Res., 2019, 33(10), 1495-1499.
[http://dx.doi.org/10.1080/14786419.2017.1419224] [PMID: 29281898]
[59]
Ganesan, V.; Gurumani, V.; Kunjiappan, S.; Panneerselvam, T.; Somasundaram, B.; Kannan, S.; Chowdhury, A.; Saravanan, G.; Bhattacharjee, C. Optimization and analysis of microwave-assisted extraction of bioactive compounds from Mimosa pudica L. Using RSM & ANFIS modeling. J. Food Meas. Charact., 2018, 12(1), 228-242.
[http://dx.doi.org/10.1007/s11694-017-9634-y]
[60]
Gopinath, M.; Bharathiraja, B.; Iyyappan, J.; Gnanasekaran, R.; Yuvaraj, D.; Dhithya, V. Extracellular green synthesis of silver nanoparticles using extract of Mimosa pudica leaves and assessment of antibacterial and antifungal activity. Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci., 2020, 90(5), 1025-1033.
[http://dx.doi.org/10.1007/s40011-020-01175-1]
[61]
Muhammad, G.; Hussain, M.A.; Jantan, I.; Bukhari, S.N.A.; Bukhari, A. Mimosa pudica L., a high-value medicinal plant as a source of bioactives for pharmaceuticals. Compr. Rev. Food Sci. Food Saf., 2016, 15(2), 303-315.
[http://dx.doi.org/10.1111/1541-4337.12184] [PMID: 33371596]
[62]
Thirumalai, T.; Elumalai, E.K.; Therasa, S.V.; Senthilkumar, B.; David, E. Ethnobotanical survey of folklore plants for the treatment of jaundice and snakebites in vellore districts of Tamilnadu, India. Ethnobot. Leafl., 2010, 14, 529-536.
[63]
Tarakeswara Naidu, M.; Chandra Babu, N.; Venkaiah, M. Ethnic remedies against snake bite from Kotia Hills of Vizianagaram District, Andhra Pradesh, India. Indian J. Nat. Prod. Resour., 2013, 4(2), 194-196.
[64]
Meenatchisundaram, S.; Priyagrace, S.; Vijayaraghavan, R.; Velmurugan, A.; Parameswari, G.; Michael, A. Antitoxin activity of Mimosa pudica root extracts against Naja naja and Bangarus caerulus Venoms. Bangladesh J. Pharmacol., 2009, 4(2), 105-109.
[http://dx.doi.org/10.3329/bjp.v4i2.2276]
[65]
Ambikabothy, J.; Ibrahim, H.; Ambu, S.; Chakravarthi, S.; Awang, K.; Vejayan, J. Efficacy evaluations of Mimosa pudica tannin isolate (MPT) for its anti-ophidian properties. J. Ethnopharmacol., 2011, 137(1), 257-262.
[http://dx.doi.org/10.1016/j.jep.2011.05.013] [PMID: 21640180]
[66]
Ameh, M.P.; Mohammed, M.; Ofemile, Y.P.; Mohammed, M.G.; Gabriel, A.; Isaac, A.O. Detoxifying action of aqueous extracts of Mucuna pruriens seed and Mimosa pudica root against venoms of Naja nigricollis and Bitis arietans. Recent Pat. Biotechnol., 2020, 14(2), 134-144.
[http://dx.doi.org/10.2174/1872208313666191025110019] [PMID: 31652115]
[67]
Fy, S.; Vejayan, J.; Jamuna, A.; Ambu, S. Efficacy of Tannins from Mimosa pudica and tannic acid in neutralizing cobra (Naja kaouthia) venom. J. Venom. Anim. Toxins Incl. Trop. Dis., 2011, 17(1), 42-48.
[http://dx.doi.org/10.1590/S1678-91992011000100006]
[68]
Permender, R.; Hema, C.; Sushila, R.; Dharmender, R.; Vikash, K. Antidiabetic potential of fabaceae family: An overview. Curr. Nutr. Food Sci., 2010, 6(3), 161-175.
[http://dx.doi.org/10.2174/157340110792389163]
[69]
S, U.; PS, M. P. Antihyperglycaemic Effect of “Ilogen-Excel”, an ayurvedic herbal formulation in streptozotocin-induced diabetes mellitus. Acta Pol. Pharm., 2007, 64(1), 53-61.
[70]
Manosroi, J.; Moses, Z.Z.; Manosroi, W.; Manosroi, A. Hypoglycemic activity of Thai medicinal plants selected from the Thai/Lanna medicinal recipe database MANOSROI II. J. Ethnopharmacol., 2011, 138(1), 92-98.
[http://dx.doi.org/10.1016/j.jep.2011.08.049] [PMID: 21925259]
[71]
Bashir, R.; Aslam, B.; Javed, I.; Muhammad, F.; Sindhu, Z.; Sarfraz, M.; Fayyaz, A. Antidiabetic efficacy of Mimosa pudica (Lajwanti) root in albino rabbits. Int. J. Agric. Biol., 2013, 15(4), 783-786.
[72]
Tunna, T.S.; Ahmed, Q.U.; Uddin, A.H.M.H.; Sarker, M.Z.I. Weeds as alternative useful medicinal source: Mimosa pudica Lnn. on diabetes mellitus and its complications. Adv. Mat. Res., 2014, 995, 49-59.
[http://dx.doi.org/10.4028/www.scientific.net/AMR.995.49]
[73]
Tunna, T.S.; Zaidul, I.S.M.; Ahmed, Q.U.; Ghafoor, K.; Al-Juhaimi, F.Y.; Uddin, M.S.; Hasan, M.; Ferdous, S. Analyses, and profiling of extract and fractions of neglected weed Mimosa pudica Lnn. traditionally used in Southeast Asia to treat diabetes. S. Afr. J. Bot., 2015, 99, 144-152.
[http://dx.doi.org/10.1016/j.sajb.2015.02.016]
[74]
Amalraj, T.; Ignacimuthu, S. Hyperglycemic effect of leaves of Mimosa pudica Linn. Fitoterapia, 2002, 73(4), 351-352.
[http://dx.doi.org/10.1016/S0367-326X(02)00079-5] [PMID: 12234583]
[75]
Piyapong, Y.; Ampa, K. Hypoglycemic and hypolipidemic activities of ethanolic extract from Mimosa pudica L. in normal and streptozotocin-induced diabetic rats | FullTxt. Org. Pharmacogn. J., 2017, 9(6), 834-837.
[http://dx.doi.org/10.5530/pj.2017.6.130]
[76]
Konsue, A.; Picheansoonthon, C.; Talubmook, C. Fasting blood glucose levels and hematological values in normal and streptozotocin-induced diabetic rats of Mimosa pudica L. Extracts. Pharmacogn. J., 2017, 9(3), 315-322.
[http://dx.doi.org/10.5530/pj.2017.3.54]
[77]
Hossain, U.; Das, A.K.; Ghosh, S.; Sil, P.C. An overview on the role of bioactive α-glucosidase inhibitors in ameliorating diabetic complications. Food Chem. Toxicol., 2020, 145(September), 111738.
[http://dx.doi.org/10.1016/j.fct.2020.111738] [PMID: 32916220]
[78]
Anitha, V.; Bupesh, G.; Vasanth, S.; Tirumalai Vasan, P.; Sahoo, U.; Humane, P. Therapeutic efficacy of Mimosa pudica-Aegle marmelos formulation on diabetes mellitus. Int. J. Res. Pharm. Sci., 2020, 11(3), 4089-4094.
[http://dx.doi.org/10.26452/ijrps.v11i3.2611]
[79]
Le Thoa, N.T.; Nam, P.C.; Nhat, D.M. Antibacterial activities of the extracts of Mimosa pudica L. An in-vitro study. Int. J. Adv. Sci. Eng. Inf. Technol., 2015, 5(5), 358-361.
[http://dx.doi.org/10.18517/ijaseit.5.5.582]
[80]
Muhammad, G.; Hussain, M.A.; Amin, M.; Hussain, S.Z.; Hussain, I.; Abbas Bukhari, S.N.; Naeem-Ul-Hassan, M. Glucu-ronoxylan-mediated silver nanoparticles: Green synthesis, an-timicrobial, and wound healing applications. RSC Adv, 2017, 7(68), 42900-42908.
[http://dx.doi.org/10.1039/C7RA07555C]
[81]
Wadankar, G.D.; Malode, S.N.; Sarambekar, S.L. Traditionally used medicinal plants for wound healing in the Washim district, Maharashtra (India). Int. J. Pharm. Tech. Res., 2011, 3(4), 2080-2084.
[82]
Bakoriya, R.; Thomas, T.; Saxena, R.C. Ethanomedicinal survey of plants of Sehore District of M.P. showing wound healing activity. Biosci. Biotechnol. Res. Asia, 2011, 8(1), 341-343.
[http://dx.doi.org/10.13005/bbra/869]
[83]
Kannan, S.; Jesuraj, S.A.V.; Kumar, E.S.J.; Saminathan, K.; Suthakaran, R.; Kumar, M.R.; Devi, B.P. Wound Healing Activity of Mimosa pudica Lnn. Formulation. Int. J. Pharm. Tech. Res., 2009, 1(4), 1554-1558.
[84]
Kokane, D.D.; More, R.Y.; Kale, M.B.; Nehete, M.N.; Mehendale, P.C.; Gadgoli, C.H. Evaluation of wound healing activity of root of Mimosa pudica. J. Ethnopharmacol., 2009, 124(2), 311-315.
[http://dx.doi.org/10.1016/j.jep.2009.04.038] [PMID: 19397984]
[85]
Pal Singh, M.; Bharghava, S.; Bhaduaria, R.S.; Sharma, C.S. Wound Healing Potential of Alcoholic Extract of Mimosa pudica Lnn. Leaves. Pharmacologyonline, 2010, 2, 32-38.
[86]
Venkateshwarlu, G.; Vijayabhaskar, K.; Pavankumar, G.; Kirankumr, P.; Harishbabu, K.; Malothu, R. Wound Healing Activity of Mimosa pudica in Albino Wistar Rats. J. Chem. Pharm. Res., 2011, 3(5), 556-560.
[87]
Mistry, S.; Patidar, R.; Vyas, V.; Jena, J.; Dutt, K.R. Anti-Inflammatory Activity of Mimosa pudica Lnn. (Mimosaceae)Leaves: An Ethnopharmacological Study. J. Pharm. Sci. Res., 2012, 4(3), 1789-1791.
[88]
Kumar, V.R.; Kumar, S. Formulation and Evaluation of Mimosa pudica Gel. Int. J. Pharm. Pharm. Sci., 2011, 3(1), 55-57.
[89]
Azam, S.; Huda, A.F.; Shams, K.; Ansari, P.; Mohamed, M.K.; Hasan, M.M.; Azad, A.K.; Mondal, K.K.; Zaouad, S.M. Anti-Inflammatory and Anti-Oxidant Study of Ethanolic Extract of Mimosa pudica. J. Young Pharm., 2015, 7(3), 234-240.
[http://dx.doi.org/10.5530/jyp.2015.3.14]
[90]
Momin, F.N.; Kalai, B.R.; Godse, V.S.; Patole, N.S.; Shikalgar, T.; Naikwade, N.S. Gastroprotective effect of Mimosa pudica leaves extract on in-vivo test models in rats. J. Biol. Act. Prod. from Nat., 2011, 1(3), 160-167.
[91]
Lalitha, K.; Kulothungan, S.R. Mimosine mitigates oxidative stress in selenium deficient seedlings of Vigna radiata-Part I: Restoration of mitochondrial function. Biol. Trace Elem. Res., 2007, 118(1), 84-96.
[http://dx.doi.org/10.1007/s12011-007-0013-0] [PMID: 17848734]
[92]
Zhang, J.; Yuan, K.; Zhou, W-L.; Zhou, J.; Yang, P. Studies on the active components and antioxidant activities of the extracts of Mimosa pudica Linn. from southern China. Pharmacogn. Mag., 2011, 7(25), 35-39.
[http://dx.doi.org/10.4103/0973-1296.75899] [PMID: 21472077]
[93]
Patro, G. In vitro and in vivo antioxidant evaluation and estimation of total phenolic, flavonoidal content of Mimosa pudica L. Pharmacognosy Res., 2016, 8(11–3), 22-28.
[94]
Jennifer Suganthi, S.; Uma Devi, P.; Suba Kanmani, S. Free radical scavenging potential and HPTLC profile of Mimosa pudica. Res. J. Pharm. Technol., 2011, 4(7), 1090-1094.
[95]
Kamboj, P.; Kalia, A.N. Evaluation of in-vitro (non & site-specific) antioxidant potential of Mimosa pudica roots. Int. J. Pharm. Pharm. Sci., 2011, 3(5), 497-501.
[96]
Chimsook, T. Bioactivities of Mimosa pudica and Phyllanthus niruri crude extracts collected from the locality of chaiyaphum, thailand. Adv. Mat. Res., 2014, 1044–1045, 12-15.
[http://dx.doi.org/10.4028/www.scientific.net/AMR.1044-1045.12]
[97]
Parmar, F.; Kushawaha, N.; Highland, H.; George, L-B. In vitro antioxidant and anticancer activity of Mimosa pudica lnn. extract and L-mimosine on lymphoma daudi cells. Int. J. Pharm. Pharm. Sci., 2015, 7(12), 100-104.
[98]
Suganya, K.S.U.; Govindaraju, K.; Kumar, V.G.; Prabhu, D.; Arulvasu, C.; Dhas, T.S.; Karthick, V.; Changmai, N. Anti-Proliferative effect of biogenic gold nanoparticles against breast cancer cell lines (MDA-MB-231 & MCF-7). Appl. Surf. Sci., 2016, 371, 415-424.
[http://dx.doi.org/10.1016/j.apsusc.2016.03.004]
[99]
Dasgupta, D.; Dash, S. Evaluation of in vivo anticancer and immunostimulatory activity of flowers of Mimosa pudica Lnn. (Fabaceae). Asian J. Pharm. Clin. Res., 2017, 10(7), 266-271.
[http://dx.doi.org/10.22159/ajpcr.2017.v10i7.18514]
[100]
Monday, O.F.; Ekiokakpo, N.P.; Chukwuma, E.F.; Obari, M.O. Chemo-herbal potentials of fractionalized extract of mimosa pudica in cadmium-induced hepatocellular tumor with associated alphafetoprotein and gamma-glutamyl transferase elevation. Acta Fac. Medicae Naissensis, 2019, 36(3), 198-206.
[http://dx.doi.org/10.5937/afmnai1903199F]
[101]
Lisina, K.V.; Ragavendran, P.; Sophia, D.; Rajamanikandan, S.; Sindhu, T.; Durgapriya, D.; Gopalakrishnan, V.K. A comparative study of justicia adhatoda, Mimosa pudica and vitex negundo against hepatoprotective activity in albino rats - in vivo evaluation. Pharmacologyonline, 2011, 1, 481-491.
[102]
Kumaresan, R.; Veerakumar, S.; Elango, V. A study on hepatoprotective activity of Mimosa pudica in Albino Rats. Int. J. Pharmacogn. Phytochem. Res., 2015, 7(2), 337-339.
[103]
Jamuna Devi, Y. Antifertility activity of different extracts of Mimosa pudica lnn. leaves in female rats. Int. J. Sci. Res., 2015, 6(3), 826-830.
[104]
Geetha, K.; Sindhu, B.; Umamaheshwera, R.V. Nephroprotective, nephrocurative activity of Mimosa pudica root against gentamicin induced nephrotoxicity. Int. J. Pharm. Pharm. Sci., 2015, 7(4), 173-177.
[105]
Onyije, F.M.; Nwanze, M.C.; Alade, G.O.; Alade, T.O.; Mgbere, O.O.; Okpora, C.K. Mimosa pudica protects the testes against cadmium-induced inflammation and oligospermia: Potential benefits in treatment of heavy metal toxicity. Pathophysiology, 2018, 25(4), 293-297.
[http://dx.doi.org/10.1016/j.pathophys.2018.04.005] [PMID: 29739640]
[106]
Ijaz, S.; Shoaib Khan, H.M.; Anwar, Z.; Talbot, B.; Walsh, J.J. HPLC profiling of Mimosa pudica polyphenols and their non-invasive biophysical investigations for anti-dermatoheliotic and skin reinstating potential. Biomed. Pharmacother., 2019, 109(109), 865-875.
[http://dx.doi.org/10.1016/j.biopha.2018.10.089] [PMID: 30551540]
[107]
Chen, W-M.; Wu, C-H.; James, E.K.; Chang, J-S. Metal biosorp-tion capability of Cupriavidus taiwanensis and its effects on heavy metal removal by nodulated Mimosa pudica. J. Hazard. Mater., 2008, 151(2-3), 364-371.
[http://dx.doi.org/10.1016/j.jhazmat.2007.05.082] [PMID: 17624667]
[108]
Budhadev, B.; Rubul, S.; Sabitry, B.; Hari Prasad, S. Phytoremediation of Petroleum Hydrocarbon (PHC) contaminated soil by using Mimosa pudica L. J. Environ. Sci. Eng., 2014, 56(3), 327-332.
[PMID: 26563085]
[109]
Sampanpanish, P.; Nanthavong, K. Effect of EDTA and NTA on arsenic bioaccumulation and translocation using phytoremediation by Mimosa pudica l. from contaminated soils. Bull. Environ. Contam. Toxicol., 2019, 102(1), 140-145.
[http://dx.doi.org/10.1007/s00128-018-2502-6] [PMID: 30478613]
[110]
Ahmad, H.; Sehgal, S.; Mishra, A.; Gupta, R. Mimosa pudica L. (Laajvanti): An overview. Pharmacognosy Rev., 2012, 6(12), 115-124.
[http://dx.doi.org/10.4103/0973-7847.99945]
[111]
Duyu, T.; Khanal, P.; Khatib, N.A.; Patil, B.M. Mimosa pudica modulates neuroactive ligand-receptor interaction in Parkinson’s disease. Indian J. Pharm. Educ. Res., 2020, 54(3), 732-739.
[http://dx.doi.org/10.5530/ijper.54.3.124]
[112]
Duyu, T.; Khatib, N.; Khanal, P.; Patil, B.; Hullatti, K. Network pharmacology-based prediction and experimental validation of Mimosa pudica for Alzheimer’s disease. J. Phytopharm., 2020, 9(1), 46-53.
[http://dx.doi.org/10.31254/phyto.2020.9108]
[113]
Kaur, J.; Sidhu, S.; Chopra, K.; Khan, M.U. Protective effect of Mimosa pudica L. in an L-arginine model of acute necrotising pancreatitis in rats. J. Nat. Med., 2016, 70(3), 423-434.
[http://dx.doi.org/10.1007/s11418-016-0991-3] [PMID: 27164910]
[114]
Niraimathee, V.A.; Subha, V.; Ernest Ravindran, R.S.; Renganathan, S. Green synthesis of iron oxide nanoparticles from Mimosa pudica root extract. Int. J. Environ. Sustain. Dev., 2016, 15(3), 227-240.
[http://dx.doi.org/10.1504/IJESD.2016.077370]
[115]
Pirathiba, S.; Ganaie, S.U.; Rajalakshmi, R.; Abbasi, T.; Abbasi, S.A. Synthesis of AuNPs with catalytic and antioxidant properties using the dreaded weed mimosa. Bioinspired. Biomim. Nanobiomaterials, 2016, 7(4), 202-212.
[http://dx.doi.org/10.1680/jbibn.17.00028]
[116]
Bhat, V.S.; Hegde, G.; Nasrollahzadeh, M. A sustainable technique to solve growing energy demand: Porous carbon nanoparticles as electrode materials for high-performance supercapacitors. J. Appl. Electrochem., 2020, 50(12), 1243-1255.
[http://dx.doi.org/10.1007/s10800-020-01479-0]
[117]
James, J.P.; Priya, S.; Jyothi, D. Effect of PLGA polymer on antimicrobial activity and the release studies of nanoparticle hydrogel containing Mimosa pudica extract. Res. J. Pharm. Technol., 2018, 11(7), 2876-2880.
[http://dx.doi.org/10.5958/0974-360X.2018.00530.9]
[118]
James, J.P.; Priya, S.; Jyothi, D. Nanoparticulate hydrogel incorporated with mimosa pudica extract : formulation and characterization. 10th Int. Conf. Biol. Biomed. Med. Pharm. Sci. (Cellular Mol. Approach),, 2017, pp. 104-109.
[119]
Muhammad, G.; Amin, M.; Hussain, M.A.; Sher, M.; Hussain, M. Comparative isoconversional thermal analysis and degradation kinetics of acetylated Mimosa pudica (Touch-Me-Not) hydrogel. J. Chem. Soc. Pak., 2016, 38(1), 1-10.
[120]
Muhammad, G.; Hussain, M.A.; Ashraf, M.U.; Haseeb, M.T.; Hussain, S.Z.; Hussain, I. Polysaccharide based superabsorbent hydrogel from Mimosa pudica: Swelling-deswelling and drug release. RSC Advances, 2016, 6(28), 23310-23317.
[http://dx.doi.org/10.1039/C5RA23088H]
[121]
Muhammad, G.; Hussain, M.A.; Ashraf, M.U.; Naeem-ul-Hassan, M.; Bukhari, S.N.A. Appraisal of acute oral toxicity of glucuronoxylan hydrogel from Mimosa pudica seeds. Braz. J. Pharm. Sci., 2018, 54(3)
[http://dx.doi.org/10.1590/s2175-97902018000317579]
[122]
Peng, M.C.; Sethu, V.; Selvarajoo, A. Performance study of chia seeds, chia flour and Mimosa pudica hydrogel as polysaccharidebased superabsorbent polymers for sanitary napkins. Mater. Today Commun., 2021, 26, 101712.
[http://dx.doi.org/10.1016/j.mtcomm.2020.101712]
[123]
Augustine, R.; Hasan, A.; Yadu Nath, V.K.; Thomas, J.; Augustine, A.; Kalarikkal, N.; Moustafa, A.A.; Thomas, S. Electrospun polyvinyl alcohol membranes incorporated with green synthesized silver nanoparticles for wound dressing applications. J. Mater. Sci. Mater. Med., 2018, 29(11), 163.
[http://dx.doi.org/10.1007/s10856-018-6169-7] [PMID: 30392046]
[124]
Babu, V.R.; Chandrasekaran, P.; Ariharasudhan, S.; Natarajan, S. Investigation on the application of Mimosa pudica and Azadirachta indie leaf methanol extract on cotton gauze fabric. Colourage, 2019, 66(10), 34-42.
[125]
Kohli, M.; Kumar, D.K.; Bole, D.S. Molecular docking and molecular dynamics simulation of the anticancer active ligand from Mimosa pudica to the fibronectin extra domain A (EDA); Oxford Coll. Sci: Bengaluru, 2021.
[126]
Kalimuthu, A.K.; Panneerselvam, T.; Pavadai, P. Kumar Pandian, S.R.; Sankaranarayanan, M.; Ammunje, D.M.; Kumar, S.; Arunachalam, S.; Kunjiappan, S. Graph theoretical network analysis and pharmacoinformatics-based investigation of bioactive compounds of Rasam (South Indian recipe) against human cancer. Sci. Rep., 2021, 11(1), 1-9.

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy