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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

An Updated and Focused Review on Heterocyclic Inhibitors for SARS-CoV and SARS-CoV-2 3CLpro

Author(s): Ajay Manaithiya, Ozair Alam*, Shruti Mittal, Mohd. Javed Naim, Mohd. Imran, Ahmed Subeh Alshrari, Aadil A. Sheikh and Imran A Khan

Background: SARS-CoV and SARS-CoV-2 are extremely infective and frequently cause severe respiratory issues (acute respiratory syndrome). These emerging viruses represent huge challenges to worldwide health. Reliable and systematic examination of SARS-CoV and COVID-19 will assist in identifying infectious persons accurately. Based on the biological, chemical, and genetic link of SARS CoV-2 towards SARS−CoV, the recurrence of different anti-SARS−CoV natural drug molecules may be beneficial in the advancement of anti COVID-19 herbal drug molecules. Here, we reviewed published literature on SAR, and molecular docking study of previously synthesized derivatives, which targeted SARS-CoV along with future prospects on SARS-CoV-2 have been reviewed. This study would assist researchers in developing newer/novel potential molecules that would target SAR-CoV-2.

Objectives: The review highlights the inhibition potential of heterocyclic inhibitors for SARS-CoV and SARS-CoV-2. The structure-activity relationship of potential compounds has been discussed. Evidence acquisition: We carried out a thorough literature assessment employing electronic databases for scientific articles highlighting potential heterocyclic inhibitors for SARS-CoV and SARS-CoV-2, published from 2010 to 2021. We recovered 415 articles, but only 220 were involved and conversed in this manuscript. The article apprehended appropriate research considering three areas: 1) SAR activity, 2) Molecular docking, and 3) Biological activity and future prospects on SARS-CoV-2.

Methods: The potential compounds with good inhibition are discussed, and their inhibition is expressed in terms of IC50.

Results: Heterocyclic scaffolds reflected an extensive range of therapeutic activity and may act as an initiating idea for designing and discovering potential inhibitors for SARS-CoV and SARS-CoV-2 treatment.

Conclusion: The points highlighted here may prove to be a vital tool for medicinal chemists working/investigating more potent and efficacious scaffolds in treating SARS-CoV and SARS-CoV-2.

Keywords: SARS-CoV, SARS-CoV-2, biological activity, structure-activity relationship, molecular docking

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