Abstract
Background: Ruta graveolens L. belongs to Rutaceae; it is a semi-wood perennial or a small evergreen sub-shrub, which is native to Southern Europe, West Asia and Northern Africa.
Objective: The goal of this manuscript was to outline the most notable traditional and modern advantages and pharmaceutical benefits of common rue.
Methods: The manuscript covers review articles, randomized control experiments, analytical studies and observations, which have been gathered from different sources, such as Google Scholar, Scopus, Science Direct and PubMed. A review of the literature was carried out using the keywords rutin, Ruta graveolens L., rue, common rune, coumarin, natural products and pharmaceutical benefits.
Results: Rue contains quinoline alkaloids, such as graveoline and graveolinine, acridone alkaloids, such as furacridone and gravacridone, furanoquinoline dictamnine, coumarins, such as gravelliferone, isorutarin, rutacultin, rutaretin, and suberenone, and the furanocoumarins 5-methoxypsoralen (bergapten) and 8-methoxypsoralen (xanthotoxine). Most of its aromatic and medicinal properties are due to the presence of rutin and its essential oil. It has been used in folk medicine as a stimulant, for its antiinflammatory and analgesic properties, anti-androgenic activity, anti-hyperglycemic effects, antihyperlipidemic effects, xanthine oxidase inhibition activity, and anticancer properties.
Conclusion: According to pharmacological and phytochemical advantages, pennyroyal shows its importance as a medicinal plant in both modern medicinal science and traditional medicine.
Keywords: Rutin, common rue, rue, Ruta graveolens, traditional medicine, natural products.
[http://dx.doi.org/10.1016/j.jep.2021.114080] [PMID: 33798662]
[http://dx.doi.org/10.3390/medicina56030097] [PMID: 32110920]
[PMID: 24250549]
[http://dx.doi.org/10.1186/s40816-021-00255-7]
[PMID: 33350538]
[http://dx.doi.org/10.15835/nbha48412002]
[http://dx.doi.org/10.1080/10942912.2020.1828456]
[http://dx.doi.org/10.1177/1934578X20951431]
[http://dx.doi.org/10.1080/09064710.2020.1763448]
[PMID: 33907670]
[http://dx.doi.org/10.1186/s13002-020-00419-8] [PMID: 33243238]
[http://dx.doi.org/10.2174/1389557520666201127104907] [PMID: 33245271]
[http://dx.doi.org/10.5530/pc.2021.1.4]
[http://dx.doi.org/10.1016/j.sjbs.2017.09.009] [PMID: 29472777]
[http://dx.doi.org/10.1016/j.nbt.2008.02.002] [PMID: 18504023]
[http://dx.doi.org/10.1016/j.supflu.2016.10.008]
[http://dx.doi.org/10.1016/j.jep.2020.113076] [PMID: 32534112]
[http://dx.doi.org/10.1016/j.jfda.2016.04.001] [PMID: 28911677]
[http://dx.doi.org/10.1016/j.plantsci.2004.11.001]
[http://dx.doi.org/10.1016/j.phytochem.2004.03.003] [PMID: 15110689]
[http://dx.doi.org/10.1016/j.jfda.2015.03.005] [PMID: 28911711]
[http://dx.doi.org/10.1080/12538078.2011.10516301]
[http://dx.doi.org/10.1016/S0165-022X(00)00079-8] [PMID: 10869689]
[http://dx.doi.org/10.1080/0972060X.2012.10644047]
[http://dx.doi.org/10.1080/10412905.1997.10554263]
[http://dx.doi.org/10.1080/10412905.1989.9697787]
[http://dx.doi.org/10.1016/S0031-9422(00)90269-3]
[http://dx.doi.org/10.1016/S0176-1617(11)81837-7]
[http://dx.doi.org/10.3923/rjmp.2009.41.44]
[http://dx.doi.org/10.1080/10496475.2012.662929]
[http://dx.doi.org/10.1016/S0168-9452(01)00413-7]
[http://dx.doi.org/10.1016/S0031-9422(02)00284-4] [PMID: 12409025]
[http://dx.doi.org/10.12816/0027560]
[http://dx.doi.org/10.1080/23802359.2019.1678426] [PMID: 33366131]
[http://dx.doi.org/10.1155/2012/685427]
[http://dx.doi.org/10.1016/j.jep.2007.09.004] [PMID: 18029123]
[http://dx.doi.org/10.1177/1934578X0600101006]
[http://dx.doi.org/10.1111/j.1600-0536.1983.tb04390.x] [PMID: 6617186]
[http://dx.doi.org/10.1016/j.yexcr.2018.01.025] [PMID: 29366810]
[http://dx.doi.org/10.13057/nusbiosci/n110105]
[http://dx.doi.org/10.4103/0970-1591.33720] [PMID: 19718326]
[http://dx.doi.org/10.4103/0253-7613.71898] [PMID: 21189902]
[http://dx.doi.org/10.3109/01658109309038150]
[http://dx.doi.org/10.1016/j.bse.2021.104223]
[http://dx.doi.org/10.1016/j.contraception.2004.07.014] [PMID: 15639078]
[http://dx.doi.org/10.1016/j.revhom.2017.03.008]
[http://dx.doi.org/10.1016/j.ijfoodmicro.2020.108649] [PMID: 32402917]
[http://dx.doi.org/10.1016/j.reprotox.2003.07.002] [PMID: 14613818]
[http://dx.doi.org/10.1371/journal.pone.0118864] [PMID: 25785932]
[http://dx.doi.org/10.1016/j.indcrop.2015.08.045]
[http://dx.doi.org/10.1016/j.foodchem.2013.03.007] [PMID: 23768355]
[http://dx.doi.org/10.1080/13880209.2020.1762669] [PMID: 32432948]
[http://dx.doi.org/10.4172/2329-6836.1000195]
[http://dx.doi.org/10.1016/j.jtcme.2020.05.002] [PMID: 32670826]
[http://dx.doi.org/10.3109/15419061.2014.926476] [PMID: 25056565]
[PMID: 21273604]
[http://dx.doi.org/10.1016/j.homp.2014.10.001] [PMID: 25576270]
[http://dx.doi.org/10.1016/S2095-4964(15)60156-X] [PMID: 25609370]
[http://dx.doi.org/10.1016/j.homp.2016.05.004] [PMID: 27914569]
[PMID: 27272785]
[PMID: 23926522]
[http://dx.doi.org/10.1080/14786419.2014.903395] [PMID: 24697339]
[http://dx.doi.org/10.17795/jjhr-21870]
[http://dx.doi.org/10.1016/j.jep.2005.09.008] [PMID: 16207519]
[http://dx.doi.org/10.1016/j.etp.2010.01.007] [PMID: 20163942]
[http://dx.doi.org/10.3109/13880209.2013.802353] [PMID: 24033089]
[http://dx.doi.org/10.1016/j.fitote.2005.02.008] [PMID: 15890462]
[http://dx.doi.org/10.1080/23312009.2016.1220055]
[http://dx.doi.org/10.1016/j.fjps.2018.09.001]
[http://dx.doi.org/10.1016/j.prp.2018.07.006] [PMID: 30025594]
[http://dx.doi.org/10.22159/ajpcr.2017.v10i2.15726]
[http://dx.doi.org/10.1016/j.jaim.2015.09.002] [PMID: 27297508]
[http://dx.doi.org/10.1021/jf0259361] [PMID: 12568545]
[http://dx.doi.org/10.1080/02772240903092306]
[http://dx.doi.org/10.1080/10412905.2014.882276]
[http://dx.doi.org/10.1016/j.sajb.2020.07.005]
[http://dx.doi.org/10.3390/app112411753]
[http://dx.doi.org/10.12816/0027560]
[http://dx.doi.org/10.1016/j.sajb.2015.03.198]
[http://dx.doi.org/10.1080/23312009.2016.1220055]
[http://dx.doi.org/10.4103/JLP.JLP_160_17] [PMID: 30078970]