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CNS & Neurological Disorders - Drug Targets


ISSN (Print): 1871-5273
ISSN (Online): 1996-3181


Role of G-Proteins and GPCR-Mediated Signalling in Neuropathophysiology

Author(s): Md. Mominur Rahman, Sadia Afsana Mim, Md. Rezaul Islam, Nasrin Sultana, Muniruddin Ahmed and Mohammad Amjad Kamal*

Volume 22, Issue 1, 2023

Published on: 09 June, 2022

Page: [2 - 5] Pages: 4

DOI: 10.2174/1871527321666220430142722


G-protein-coupled receptors (GPCRs) are activated by manifold neurotransmitters, and their activation, in turn, evokes slow synaptic transmission. They are profoundly related to numerous psychiatric and neurological disorders such as schizophrenia and Parkinson's disease. The significant malady indications for GPCR modulators demonstrate a change towards obesity, diabetes, and Alzheimer's disease, while other central nervous system disorders persist highly represented. GPR52, GPR6, and GPR8 are recognised as orphan GPCRs, co-exist either with both the dopamine D2 and D1 receptors in neurons of the basal ganglia or with the dopamine D2 receptor alone, and recommend that between these orphan receptors, GPR52 has the maximum potential of being a therapeutic psychiatric receptor. Genetically modified creature models and molecular biological investigations have suggested that these improved GPCRs could be potential therapeutic psychiatric receptors. In this perspective, the role of molecular targets in GPCR-mediated signalling has been discussed that would be novel drug design and discovery options for a scientist to elaborate previous knowledge with modern techniques.

Keywords: Alzheimer's disease, G protein-coupled receptors, neuropathophysiology, psychiatric receptors, neurotransmitters, neurological disorders.

Graphical Abstract
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