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Recent Advances in Drug Delivery and Formulation

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ISSN (Print): 2667-3878
ISSN (Online): 2667-3886

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Research Article

Exploring the Patent Landscape and Innovation of Hydrogel-based Bioinks Used for 3D Bioprinting

Author(s): Ahmed Fatimi*

Volume 16, Issue 2, 2022

Published on: 21 June, 2022

Page: [145 - 163] Pages: 19

DOI: 10.2174/2667387816666220429095834

Price: $65

Abstract

Background: This paper provides a comprehensive overview of the patent situation for hydrogel- based bioinks used for 3D bioprinting globally. It encapsulates information which could be used as a reference by researchers in the fields of 3D bioprinting, biomaterials, tissue engineering, and biomedical engineering, as well as those interested in biomaterials, especially in the formulation of hydrogels. It can also inform policy discussions, strategic research planning, or technology transfer in this area. The findings presented hereinafter are considered novel research aspects regarding the used hydrogels, their preparation methods, and their formulations, as well as the 3D bioprinting process using hydrogels. Furthermore, the novel part, synthesized patents, is regarded as a breakthrough in hydrogel- based bioinks.

Methods: The following research aspects of this study are based on data collection from selected patent databases. The search results are then analyzed according to publication years, classification, inventors, applicants, and owners, as well as jurisdictions.

Results: Based on the earliest priority date, it is possible to precisely assume that 2004 is considered the starting year of patenting of hydrogel-based bioinks. Furthermore, 2020 was the year with the most patent documents. According to the findings, the United States, China, and the Republic of Korea are the most prolific countries in terms of patenting on hydrogel-based bioinks. The most prolific patenting companies are from the United States, Sweden, and Australia, while universities from the Republic of Korea and the United States are the academic institutions leading the way. Most inventions of hydrogel- based bioinks intended for hydrogels or hydrocolloids used as materials for prostheses or for coating prostheses are characterized by their function or physical properties.

Conclusion: The state has been reviewed by introducing what has been patented concerning hydrogelbased bioinks. Knowledge clusters and expert driving factors indicate that the research based on biomaterials, tissue engineering, and biofabrication is concentrated in the most common patent documents. Finally, this paper, which gives a competitive analysis of the past, present, and future trends in hydrogel-based bioinks, leads to various recommendations that could help one to plan and innovate research strategies.

Keywords: Hydrogels, bioinks, 3D bioprinting, intellectual property, patent, innovation.

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[1]
Groll J, Boland T, Blunk T, et al. Biofabrication: Reappraising the definition of an evolving field. Biofabrication 2016; 8(1): 013001.
[http://dx.doi.org/10.1088/1758-5090/8/1/013001] [PMID: 26744832]
[2]
Donderwinkel I, van Hest JCM, Cameron NR. Bio-inks for 3D bioprinting: Recent advances and future prospects. Polym Chem 2017; 8(31): 4451-71.
[http://dx.doi.org/10.1039/C7PY00826K]
[3]
Lin H-H, Hsieh F-Y, Tseng C-S, Hsu SH. Preparation and characterization of a biodegradable polyurethane hydrogel and the hybrid gel with soy protein for 3D cell-laden bioprinting. J Mater Chem B Mater Biol Med 2016; 4(41): 6694-705.
[http://dx.doi.org/10.1039/C6TB01501H] [PMID: 32263524]
[4]
Schwartz R, Malpica M, Thompson GL, Miri AK. Cell encapsulation in gelatin bioink impairs 3D bioprinting resolution. J Mech Behav Biomed Mater 2020; 103: 103524.
[http://dx.doi.org/10.1016/j.jmbbm.2019.103524] [PMID: 31785543]
[5]
Olate-Moya F, Arens L, Wilhelm M, Mateos-Timoneda MA, Engel E, Palza H. Chondroinductive aginate-based hydrogels having graphene oxide for 3D printed scaffold fabrication. ACS Appl Mater Interfaces 2020; 12(4): 4343-57.
[http://dx.doi.org/10.1021/acsami.9b22062] [PMID: 31909967]
[6]
Fatimi A. Chitosan-based embolizing hydrogel for the treatment of endoleaks after endovascular aneurysm repair. Int J Polym Mater 2019; 68(1-3): 107-14.
[http://dx.doi.org/10.1080/00914037.2018.1525729]
[7]
Yuan T, Li Z, Zhang Y, et al. Injectable ultrasonication-induced silk fibroin hydrogel for cartilage repair and regeneration. Tissue Eng Part A 2021; 27(17-18): 1213-24.
[http://dx.doi.org/10.1089/ten.tea.2020.0323] [PMID: 33353462]
[8]
Qiao Y, Liu X, Zhou X, et al. Gelatin templated polypeptide co-cross-linked hydrogel for bone regeneration. Adv Healthc Mater 2020; 9(1): e1901239.
[http://dx.doi.org/10.1002/adhm.201901239] [PMID: 31814318]
[9]
Shie M-Y, Lee J-J, Ho C-C, Yen S-Y, Ng HY, Chen Y-W. Effects of gelatin methacrylate bio-ink concentration on mechano-physical properties and human dermal fibroblast behavior. Polymers (Basel) 2020; 12(9): 1930.
[http://dx.doi.org/10.3390/polym12091930] [PMID: 32859028]
[10]
Zhou X, Nowicki M, Sun H, et al. 3D Bioprinting-tunable small-diameter blood vessels with biomimetic biphasic cell layers. ACS Appl Mater Interfaces 2020; 12(41): 45904-15.
[http://dx.doi.org/10.1021/acsami.0c14871] [PMID: 33006880]
[11]
Wang X-F, Song Y, Liu Y-S, et al. Osteogenic differentiation of three-dimensional bioprinted constructs consisting of human adipose-derived stem cells in vitro and in vivo. PLoS One 2016; 11(6): e0157214.
[http://dx.doi.org/10.1371/journal.pone.0157214] [PMID: 27332814]
[12]
Nie K, Han S, Yang J, et al. Enzyme-crosslinked electrospun fibrous gelatin hydrogel for potential soft tissue engineering. Polymers (Basel) 2020; 12(9): 1977.
[http://dx.doi.org/10.3390/polym12091977] [PMID: 32878113]
[13]
Yu J, Park SA, Kim WD, et al. Current advances in 3D bioprinting technology and its applications for tissue engineering. Polymers (Basel) 2020; 12(12): 2958.
[http://dx.doi.org/10.3390/polym12122958] [PMID: 33322291]
[14]
Yoo S-S. 3D-printed biological organs: Medical potential and patenting opportunity. Expert Opin Ther Pat 2015; 25(5): 507-11.
[http://dx.doi.org/10.1517/13543776.2015.1019466] [PMID: 25711801]
[15]
Cambia Institute. The lens patent data set 2021. Available from: https://www.lens.org (Accessed on: September 2, 2021).
[16]
Bicudo E, Faulkner A, Li P. Patents and the experimental space: Social, legal and geographical dimensions of 3D bioprinting. Int Rev Law Comput Technol 2021; 35(1): 2-23.
[http://dx.doi.org/10.1080/13600869.2020.1785066]
[17]
Lee SM, Trimi S. Innovation for creating a smart future. Journal of Innovation & Knowledge 2018; 3(1): 1-8.
[http://dx.doi.org/10.1016/j.jik.2016.11.001]
[18]
World Intellectual Property Organization. What is intellectual property? In: Geneva, Switzerland 2020; p. 28.
[19]
Gould DM, Gruben WC. The role of intellectual property rights in economic growth. J Dev Econ 1996; 48(2): 323-50.
[http://dx.doi.org/10.1016/0304-3878(95)00039-9]
[20]
Murphy K, Dorfman S, Smith N, et al. Devices, systems, and methods for the fabrication of tissue. Patent US 9227339 B2, 2016.
[21]
O’Mahony AP, Utama RH, Fife CM, et al. Process for printing 3D tissue culture models. Patent EP 3325611 B1, 2020.
[22]
Zhang J, Pei M, Li T, Xu G, Li J, Wang L. The degradable 3D printing bio-ink of temperature-responsive and 3D printing method. Patent CN 107523136 A, 2017.
[23]
Kim SH, Choi JH, Oh SJ, Park KD, Lee JY. Hydrogel composition and bioinks composition comprising the same. Patent KR 20180117417 A, 2018.
[24]
Jung S, Yoon S. Inkjet printable bioink and method of preparing the same. Patent KR 20190054487 A, 2019.
[25]
Liu J, Cheng L, Yu S, Sun J. Preparation method of nanocellulose bio-printing gel ink. Patent CN 110028840 A, 2019.
[26]
Redwan AIN, Thayer P, Martinez H, Gatenholm E. Biogum and botanical gum hydrogel bioinks for the physiological 3D bioprinting of tissue constructs for in vitro culture and transplantation. Patent WO 2020/086941 A1, 2020.
[27]
Gatenholm P. Preparation and applications of RGD conjugated polysaccharide bioinks with or without fibrin for 3d bioprinting of human skin with novel printing head for use as model for testing cosmetics and for transplantation. Patent US 2019/0160203 A1, 2019.
[28]
Varanasi VG, Ilyas A, Kramer PR, Azimaie T, Aswath PB, Cebe T. in vivo live 3D printing of regenerative bone healing scaffolds for rapid fracture healing. Patent US 10442182 B2, 2019.
[29]
Hull CW. Apparatus for production of three-dimensional objects by stereolithography. Patent US 4575330 A, 1986.
[30]
Guvendiren M, Molde J, Soares RMD, Kohn J. Designing biomaterials for 3D printing. ACS Biomater Sci Eng 2016; 2(10): 1679-93.
[http://dx.doi.org/10.1021/acsbiomaterials.6b00121] [PMID: 28025653]
[31]
Murphy SV, Atala A. 3D bioprinting of tissues and organs. Nat Biotechnol 2014; 32(8): 773-85.
[http://dx.doi.org/10.1038/nbt.2958] [PMID: 25093879]
[32]
Klebe RJ. Cytoscribing: A method for micropositioning cells and the construction of two- and three-dimensional synthetic tissues. Exp Cell Res 1988; 179(2): 362-73.
[http://dx.doi.org/10.1016/0014-4827(88)90275-3] [PMID: 3191947]
[33]
Odde DJ, Renn MJ. Laser-guided direct writing for applications in biotechnology. Trends Biotechnol 1999; 17(10): 385-9.
[http://dx.doi.org/10.1016/S0167-7799(99)01355-4] [PMID: 10481169]
[34]
Ozbolat IT, Hospodiuk M. Current advances and future perspectives in extrusion-based bioprinting. Biomaterials 2016; 76: 321-43.
[http://dx.doi.org/10.1016/j.biomaterials.2015.10.076] [PMID: 26561931]
[35]
Landers R, Hübner U, Schmelzeisen R, Mülhaupt R. Rapid prototyping of scaffolds derived from thermoreversible hydrogels and tailored for applications in tissue engineering. Biomaterials 2002; 23(23): 4437-47.
[http://dx.doi.org/10.1016/S0142-9612(02)00139-4] [PMID: 12322962]
[36]
Jiang T, Munguia-Lopez JG, Flores-Torres S, Kort-Mascort J, Kinsella JM. Extrusion bioprinting of soft materials: An emerging technique for biological model fabrication. Appl Phys Rev 2019; 6(1): 011310.
[http://dx.doi.org/10.1063/1.5059393]
[37]
Boland T, Wilson WC, Xu T. Ink-jet printing of viable cells. Patent US 7051654 B2, 2006.
[38]
Forgacs G, Jakab K, Neagu A, Mironov V. Self-assembling cell aggregates and methods of making engineered tissue using the same. Patent US 8241905 B2, 2012.
[39]
Thorpe D, Belcher S, Nicholson J. Handheld 3D bioprinter. Patent US 2020/0130277 A1, 2020.
[40]
World intellectual property organization.. 2021. Patentscope fields definition Available from: https://patentscope.wipo.int/search/en/help/fieldsHelp.jsf (Accessed on: December 2, 2021).
[41]
World intellectual property organization.. The patentscope. 2021. Available from: https://patentscope.wipo.int (Accessed on: December 2, 2021).
[42]
World Health Organization. World Intellectual Property Organization and World Trade Organization, Promoting access to medical technologies and innovation: Intersections between public health, intellectual property and trade. In: Geneva, Switzerland 2020; p. 352.
[43]
Rodríguez-Salvador M, Rio-Belver RM, Garechana-Anacabe G. Scientometric and patentometric analyses to determine the knowledge landscape in innovative technologies: The case of 3D bioprinting. PLoS One 2017; 12(6): e0180375.
[http://dx.doi.org/10.1371/journal.pone.0180375] [PMID: 28662187]
[44]
World intellectual property organization. Handbook on industrial property information and documentation. 2013. Available from: www. wipo.int/standards/en/pdf/08-01-01.pdf (Accessed on: May 25, 2021).
[45]
European patent office. Espacenet glossary. Available from: https://worldwide.espacenet.com/patent (Accessed on: December 2, 2021).
[46]
World intellectual property organization.. IPC Publication Available from: https://www.wipo.int/classifications/ipc/ipcpub (Accessed on: January 14, 2022).
[47]
World intellectual property organization. Guide to the international patent classification (IPC).. 2021. Available from: https://www.wipo.int/edocs/pubdocs/en/wipo_guide_ipc_2020.pdf(Accessed on: December 2, 2021).
[48]
World intellectual property organization.. What is intellectual property?. 2021. Available from: https://www.wipo.int/patents/en/faq_patents.html (Accessed on: September 2, 2021).
[49]
United states patent and trademark office.. Manual of patent examining procedure: Ownership/Assignability of patents and applications. 2021. Available from: https://www.uspto.gov/web/offices/pac/mpep/mpep-0300.html (Accessed on: December 13, 2021).

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