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Drug Delivery Letters


ISSN (Print): 2210-3031
ISSN (Online): 2210-304X

Review Article

Curcumin: A Review of its’ Efficacy in the Management of Psoriasis

Author(s): K.M. Reena*, Lalit Singh and Shipra Sharma

Volume 12, Issue 3, 2022

Published on: 22 July, 2022

Page: [163 - 183] Pages: 21

DOI: 10.2174/2210303112666220428101738

Price: $65


Background: Psoriasis is a long-term chronic inflammatory, autoimmune and reoccurring skin condition. About 2% to 5% of the world's population is impacted by psoriasis. People affected by psoriasis are more prone to develop other health conditions including psoriatic arthritis, anxiety, depression and cardiovascular disorders. Long-term use of several synthetic medications used for their management has been showing typical severe side effects. Curcumin, a natural compound generated from the golden spice (Curcuma longa), has been recommended as a potential alternative for the management of psoriasis. Curcumin works at molecular level by binding with the various inflammatory receptors that play a key role in the initiation of psoriasis.

Objective: The aim of this review is to report the use and discuss the mechanism of action of curcumin in the management of psoriasis and mutually overcome the side effects shown by the synthetic medications.

Methods: For qualitative literature review PubMed, Scopus, Web of Science, Google Scholar, Google Books, and Science Direct meet the inclusion criteria.

Results: Through ample literature surveys, curcumin has been proposed as a safe and therapeutic option for psoriasis as compared to synthetic medications.

Conclusion: As traditional herb curcumin appears as a beneficiary medicament because of its antioxidant, anti-inflammatory and immune-modulating activities proposing minimal side effects. Thereby ensuring its defensive mechanism against psoriasis.

Keywords: Curcumin, turmeric, anti-inflammatory, anti-oxidant, psoriasis, bioavailability, cytokines.

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