Pyrrolocarbazoles as Checkpoint 1 Kinase Inhibitors

Title: Pyrrolocarbazoles as Checkpoint 1 Kinase Inhibitors

Volume: 8 Issue: 6

Author(s): Helene Henon, Elisabeth Conchon, Bernadette Hugon, Samir Messaoudi, Roy M. Golsteyn and Michelle Prudhomme

Affiliation:

Keywords: Checkpoint kinase 1, antitumor agents, pyrrolocarbazole, granulatimide

Abstract: The carbazole framework is found in many natural compounds of biological interest. Indolocarbazoles such as rebeccamycin and staurosporine which are either a topoisomerase I inhibitor (rebeccamycin) or a non selective kinase inhibitor (staurosporine) are bacterial metabolites. In the search for new antitumor agents, DNA damage checkpoint kinases, in particular Checkpoint kinase 1, have recently emerged as attractive targets for cancer therapy. This review reports the synthesis and Chk1 inhibitory activities of pyrrolocarbazole compounds bearing four or five fused rings.

Cite this article as:

Henon Helene, Conchon Elisabeth, Hugon Bernadette, Messaoudi Samir, Golsteyn M. Roy and Prudhomme Michelle, Pyrrolocarbazoles as Checkpoint 1 Kinase Inhibitors, Anti-Cancer Agents in Medicinal Chemistry 2008; 8(6) . https://dx.doi.org/10.2174/187152008785133100