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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286


Interaction of Vitamin D and Corticosteroid Use in Hospitalized COVID-19 Patients: A Potential Explanation for Inconsistent Findings in the Literature

Author(s): Jimmy T. Efird*, Ethan J. Anderson, Charulata Jindal and Ayako Suzuki

Volume 28, Issue 21, 2022

Published on: 23 May, 2022

Page: [1695 - 1702] Pages: 8

DOI: 10.2174/1381612828666220418132847


Vitamin D is an important immune-modulator with anti-inflammatory properties. While this prohormone has been studied extensively in the prevention and treatment of COVID-19, findings have been inconsistent regarding its overall benefit in patients hospitalized with COVID-19. Most studies to date have been observational in nature, not accounting for the use of corticosteroids. Furthermore, the few randomized clinical trials designed to examine the effect of vitamin D supplementation on COVID-19 outcomes have been relatively small and thus insufficiently powered to assure a balance of corticosteroid use between study arms. The current perspective addresses the interaction of vitamin D and corticosteroids as a potential explanation for the divergent results reported in the literature. Future research on vitamin D and COVID-19 will benefit by considering this interaction, especially among hospitalized patients requiring oxygen and mechanical ventilation.

Keywords: Anti-inflammatory, corticosteroids, COVID-19, cytokine storm, SARS-CoV-2, vitamin D.

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