Introduction: Eye movement patterns during reading are well defined and documented. Each eye movement ends up in a fixation point, which allows the brain to process the incoming information and program the following saccade. In this work, we investigated whether eye movement alterations during a reading task might be already present in middle-aged, cognitively normal offspring of late-onset Alzheimer’s disease (O-LOAD).
Methods: 18 O-LOAD and 18 age-matched healthy individuals with no family history of LOAD participated in the study. Participants were seated in front of a 20-inch LCD monitor, and single sentences were presented on it. Eye movements were recorded with an eye tracker with a sampling rate of 1000 Hz.
Results: Analysis of eye movements during reading revealed that O-LOAD displayed more fixations, shorter saccades, and shorter fixation durations than controls.
Conclusion: The present study shows that O-LOAD experienced alterations in their eye movements during reading. O-LOAD eye movement behavior could be considered an initial sign of oculomotor impairment. Hence, the evaluation of eye movement during reading might be a useful tool for monitoring well-defined cognitive resources.
[http://dx.doi.org/10.1016/j.neuropsychologia.2014.07.023] [PMID: 25080188]
[http://dx.doi.org/10.1034/j.1600-0404.107.s179.7.x] [PMID: 12603249]
[http://dx.doi.org/10.1111/j.1365-2796.2004.01386.x] [PMID: 15324363]
[http://dx.doi.org/10.1016/j.jpsychires.2019.02.016] [PMID: 30836202]
[http://dx.doi.org/10.3233/JAD-170491] [PMID: 28984601]
[http://dx.doi.org/10.1016/j.jpsychires.2018.10.008] [PMID: 30308328]
[http://dx.doi.org/10.1016/j.jalz.2011.03.003] [PMID: 21514248]
[http://dx.doi.org/10.1016/j.pscychresns.2021.111342] [PMID: 34365076]
[http://dx.doi.org/10.1176/appi.neuropsych.17120355] [PMID: 30305005]
[http://dx.doi.org/10.1016/j.jpsychires.2020.01.018] [PMID: 32044590]
[http://dx.doi.org/10.1016/j.jpsychires.2019.12.019] [PMID: 31931231]