Abstract
Primary Open Angle Glaucoma (POAG) is a blindness causing disease. The main risk factor for POAG is elevated intraocular pressure (IOP) due to insufficient outflow of aqueous humor from the eye into the vasculature. Carbohydrate- based recognition systems are increasingly recognized for their roles in physiological as well as pathogenic processes. These systems are comprised of a glycan message carried by a glycoprotein or glycolipid and a message decoder, a carbohydrate binding protein (lectin). The trabecular meshwork (TM), a prominent participant in the regulation of aqueous humor outflow facility shows expression of various lectins, including members of the classic families I-type lectins, C-type lectins and S-type lectins (Galectins). Some of these lectins, namely ICAM-1, E- and P-selectins have altered expression levels in TM derived from eyes with POAG. Another, CD44 shows elevated levels in the POAG aqueous humor. Many carbohydrate recognizing proteins, upon binding to their respective countereceptors can affect cellular processes shown to be paramount for the maintenance of outflow facility by TM. This review will survey lectins known to be expressed in TM, their known and hypothesized functions in the tissue and highlight some interesting venues for study of putative roles for lectins in the disease-promoting mechanisms taking place in POAG TM.
Current Organic Chemistry
Title: Carbohydrate-Based Recognition Systems in Primary Open Angle Glaucoma
Volume: 12 Issue: 11
Author(s): Shiri Diskin and Noorjahan Panjwani
Affiliation:
Abstract: Primary Open Angle Glaucoma (POAG) is a blindness causing disease. The main risk factor for POAG is elevated intraocular pressure (IOP) due to insufficient outflow of aqueous humor from the eye into the vasculature. Carbohydrate- based recognition systems are increasingly recognized for their roles in physiological as well as pathogenic processes. These systems are comprised of a glycan message carried by a glycoprotein or glycolipid and a message decoder, a carbohydrate binding protein (lectin). The trabecular meshwork (TM), a prominent participant in the regulation of aqueous humor outflow facility shows expression of various lectins, including members of the classic families I-type lectins, C-type lectins and S-type lectins (Galectins). Some of these lectins, namely ICAM-1, E- and P-selectins have altered expression levels in TM derived from eyes with POAG. Another, CD44 shows elevated levels in the POAG aqueous humor. Many carbohydrate recognizing proteins, upon binding to their respective countereceptors can affect cellular processes shown to be paramount for the maintenance of outflow facility by TM. This review will survey lectins known to be expressed in TM, their known and hypothesized functions in the tissue and highlight some interesting venues for study of putative roles for lectins in the disease-promoting mechanisms taking place in POAG TM.
Export Options
About this article
Cite this article as:
Diskin Shiri and Panjwani Noorjahan, Carbohydrate-Based Recognition Systems in Primary Open Angle Glaucoma, Current Organic Chemistry 2008; 12 (11) . https://dx.doi.org/10.2174/138527208784892222
DOI https://dx.doi.org/10.2174/138527208784892222 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Stroke in Women - Oral Contraception, Pregnancy, and Hormone Replacement Therapy
Current Vascular Pharmacology Perspectives of Benzimidazole Derivatives as Anticancer Agents in the New Era
Anti-Cancer Agents in Medicinal Chemistry Cytotoxic and Apoptotic Action of Nonactin and Cephaeline. HBr Precludes Alteration of Redox Status
The Natural Products Journal CD26/Dipeptidyl Peptidase IV as a Novel Therapeutic Target for Cancer and Immune Disorders
Mini-Reviews in Medicinal Chemistry Iron Chelators in Medicinal Applications - Chemical Equilibrium Considerations in Pharmaceutical Activity
Current Medicinal Chemistry Endothelial Cell Aging and Apoptosis in Prevention and Disease: E-Selectin Expression and Modulation As A Model
Current Pharmaceutical Design Intravenous Magnesium – Lidocaine - Ketorolac Cocktail for Postoperative Opioid Resistant Pain: A Case Series of Novel Rescue Therapy
Reviews on Recent Clinical Trials Myricetin Induces Apoptosis in HepG2 Cells Through Akt/p70S6K/Bad Signaling and Mitochondrial Apoptotic Pathway
Anti-Cancer Agents in Medicinal Chemistry Immunotherapy of Kidney Cancer
Current Clinical Pharmacology Novel Insights Into c-Src
Current Pharmaceutical Design NLRP3 Is Involved in Ischemia/Reperfusion Injury
CNS & Neurological Disorders - Drug Targets Dental Pulp from Human Exfoliated Deciduous Teeth-derived Stromal Cells Demonstrated Neuronal Potential: In Vivo and In Vitro Studies
Current Stem Cell Research & Therapy NSAIDs and Chemoprevention
Current Cancer Drug Targets Overview of Brain Tumor Stem Cells – Implications for Treatment
Current Signal Transduction Therapy New Uses of Melatonin as a Drug; A Review
Current Medicinal Chemistry Contemporary Progress in the Synthesis and Reaction of 2-Arylbenzothiazole: A Review
Current Organic Chemistry Multimodal Optical, X-Ray CT, and SPECT Imaging of a Mouse Model of Breast Cancer Lung Metastasis
Current Molecular Medicine Epigenetic Regulation of EMT: The Snail Story
Current Pharmaceutical Design Endostatin: Preclinical Development as an Anticancer Agent
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents HOX Genes as Potential Markers of Circulating Tumour Cells
Current Molecular Medicine