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Endocrine, Metabolic & Immune Disorders - Drug Targets


ISSN (Print): 1871-5303
ISSN (Online): 2212-3873


The Savant Syndrome: a Gift or a Disability? A Deeper Look into Metabolic Correlates of Hidden Cognitive Capacity

Author(s): Irem Onin, Lütfü Hanoglu and Burak Yulug*

Volume 23, Issue 2, 2023

Published on: 23 August, 2022

Page: [250 - 253] Pages: 4

DOI: 10.2174/1871530322666220408134359


Savant syndrome is a rare and unusual condition that occurs in the presence of severe developmental disabilities, disorders, and injuries. The syndrome can be congenital from birth to childhood or acquired as a result of a brain injury or damage to the central nervous system. There are several findings that indicate that savant syndrome usually occurs with significant brain metabolism alterations resulting in critical brain network changes. These types of changes in the brain are usually explained by the “tyranny of the left hemisphere” theory, which indicates the inhibition of the left hemisphere to allow the right hemisphere to develop savant abilities. Another way to temporarily simulate these types of changes in the brain can be through different neuromodulation techniques such as transcranial magnetic stimulation and transcranial direct current stimulation. Such neuromodulation techniques might help us discover the “hidden talent” potential through modulating the brain network metabolism. We herein discussed the types of savant syndrome along with its relation to specific neurometabolic network alterations. Furthermore, we provide a perspective on how newly developed neuromodulation and cognitive rehabilitation techniques can help simulate savant syndrome in healthy individuals through modulating the brain network activity.

Keywords: Savant syndrome, autism spectrum disorder, traumatic brain injury, acquired savant syndrome, congenital Savant syndrome, epilepsy.

« Previous
Treffert, D.A. Extraordinary people; Harper and Row: New York, 1989.
Treffert, D.A. Savant syndrome: Realities, myths and misconceptions. J. Autism Dev. Disord., 2014, 44(3), 564-571.
[] [PMID: 23918440]
Treffert, D.A. Dr. Down and “developmental disorders”. J. Autism Dev. Disord., 2006, 36(7), 965-966.
[] [PMID: 16960762]
Treffert, D.A. Islands of genius: The bountiful mind of the autistic, acquired, and sudden savant; Jessica Kingsley Publishers, 2010.
Corrigan, N.M.; Richards, T.L.; Treffert, D.A.; Dager, S.R. Toward a better understanding of the savant brain. Compr. Psychiatry, 2012, 53(6), 706-717.
[ ] [PMID: 22206802]
Treffert, D.A. The savant syndrome: An extraordinary condition. A synopsis: Past, present, future. Philos. Trans. R. Soc. Lond. B Biol. Sci., 2009, 364(1522), 1351-1357.
[] [PMID: 19528017]
O’Connor, N. The 1988 Jansson memorial lecture. The performance of the ‘idiot-savant’: Implicit and explicit. Br. J. Disord. Commun., 1989, 24(1), 1-20.
[] [PMID: 2638187]
O’Connor, N.; Hermelin, B. Do young calendrical calculators improve with age? J. Child Psychol. Psychiatry, 1992, 33(5), 907-912.
[ ] [PMID: 1634593]
Boddaert, N.; Barthélémy, C.; Poline, J.B.; Samson, Y.; Brunelle, F.; Zilbovicius, M. Autism: Functional brain mapping of exceptional calendar capacity. Br. J. Psychiatry, 2005, 187(1), 83-86.
[] [PMID: 15994576]
Anderson, J.S.; Druzgal, T.J.; Froehlich, A.; DuBray, M.B.; Lange, N.; Alexander, A.L.; Abildskov, T.; Nielsen, J.A.; Car-iello, A.N.; Cooperrider, J.R.; Bigler, E.D.; Lainhart, J.E. Decreased interhemispheric functional connectivity in autism. Cereb. Cortex, 2011, 21(5), 1134-1146.
[] [PMID: 20943668]
Heavey, L.; Pring, L.; Hermelin, B. A date to remember: The nature of memory in savant calendrical calculators. Psychol. Med., 1999, 29(1), 145-160.
[] [PMID: 10077303]
García-González, S.; Lugo-Marín, J.; Setien-Ramos, I.; Gisbert-Gustemps, L.; Arteaga-Henríquez, G.; Díez-Villoria, E.; Ramos-Quiroga, J.A. Transcranial direct current stimulation in Autism Spectrum Disorder: A systematic review and meta-analysis. Eur. Neuropsychopharmacol., 2021, 48, 89-109.
[ ] [PMID: 33773886]
Shi, L.; Beaty, R.E.; Chen, Q.; Sun, J.; Wei, D.; Yang, W.; Qiu, J. Brain entropy is associated with divergent thinking. Cereb. Cortex, 2020, 30(2), 708-717.
[] [PMID: 31233102]
Treffert, D. There is a savant in you. New Sci., 2016, 229(3056), 28-29.
Skardal, P.S.; Arenas, A. Higher order interactions in complex networks of phase oscillators promote abrupt synchronization switching. Commun. Phys., 2020, 3(1), 1-6.
Snyder, A.W.; Mulcahy, E.; Taylor, J.L.; Mitchell, D.J.; Sachdev, P.; Gandevia, S.C. Savant-like skills exposed in normal people by suppressing the left fronto-temporal lobe. J. Integr. Neurosci., 2003, 2(2), 149-158.
[] [PMID: 15011267]
Miller, B.L.; Ponton, M.; Benson, D.F.; Cummings, J.L.; Mena, I. Enhanced artistic creativity with temporal lobe de-generation. Lancet, 1996, 348(9043), 1744-1745.
[] [PMID: 8973469]
Young, R.L.; Ridding, M.C.; Morrell, T.L. Switching skills on by turning off part of the brain. Neurocase, 2004, 10(3), 215-222.
[] [PMID: 15788259]
Snyder, A.; Bahramali, H.; Hawker, T.; Mitchell, D.J. Savant-like numerosity skills revealed in normal people by magnetic pulses. Perception, 2006, 35(6), 837-845.
[] [PMID: 16836048]
Chi, R.P.; Snyder, A.W. Brain stimulation enables the solution of an inherently difficult problem. Neurosci. Lett., 2012, 515(2), 121-124.
[] [PMID: 22440856]
Hughes, J.R. A review of Savant Syndrome and its possible relationship to epilepsy. Epilepsy Behav., 2010, 17(2), 147-152.
[] [PMID: 20075011]
Sacks, O. An anthropologist on Mars: Seven paradoxical tales; Vintage, 2012.
Humphrey, N. Commentary on Michael Winkelman, ‘Sham-anism and cognitive evolution’. Camb. Archaeol. J., 2002, 12, 71-101.
Obler, L.K.; Fein, D.E. The exceptional brain: Neuropsychology of talent and special abilities; Guilford Press, 1988, pp. 493-512.
Kapur, N. Paradoxical functional facilitation in brain-behaviour research. A critical review. Brain, 1996, 119(Pt 5), 1775-1790.
[] [PMID: 8931597]
Pring, L.; Hermelin, B. Numbers and letters: Exploring an autistic savant’s unpracticed ability. Neurocase, 2002, 8(4), 330-337.
[] [PMID: 12221146]
Deco, G.; Jirsa, V.K.; McIntosh, A.R. Resting brains never rest: Computational insights into potential cognitive architectures. Trends Neurosci., 2013, 36(5), 268-274.
[] [PMID: 23561718]
Zhang, L.; Wang, X.H.; Li, L. Diagnosing autism spectrum disorder using brain entropy: A fast entropy method. Comput. Methods Programs Biomed., 2020, 190, 105240.
[] [PMID: 31806393]
Sandison, R. A parent’s guide to autism book. Tyndale House publishers, 2006 59-60.
Yulug, B; Kilic, E; Altunay, S; Ersavas, C; Orhan, C; Dalay, A; Tuzcu, M; Sahin, N; Juturu, V; Sahin, K Cinnamon polyphenol extract exerts neuroprotective activity in traumatic brain injury in male mice. CNS Neurol. Disord. Drug Targets, 2018, 17, 439-447.
[] [PMID: 29714150]

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