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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Review Article

Synthesis of Benzalacetophenone-based Isoxazoline and Isoxazole Derivatives

Author(s): Saba Farooq* and Zainab Ngaini*

Volume 26, Issue 7, 2022

Published on: 31 May, 2022

Page: [679 - 692] Pages: 14

DOI: 10.2174/1385272826666220408120350


The demand for natural product-based drugs with less cost and efficient procedures has become a challenge for researchers. Benzalacetophenone is a natural product-based species that is modified into numerous heterocyclic compounds, including isoxazoline and isoxazole derivatives. The utility of isoxazoline and oxazole derivatives has been increased for the synthesis of new and effective chemical entities to serve medicinal chemistry in the past few years. Isoxazoline and isoxazole are fascinating classes of heterocyclic compounds, which belong to N- and O-heterocycles, and are widely used as precursors for the development of drugs. This review highlights the recent work on the synthesis of mono and bis isoxazoline and isoxazole derivatives using stable benzalacetophenone and functionalization of isoxazoline and isoxazole, along with the prevailing biological properties.

Keywords: Anticancer drug, stirring, ammonium hydroxide, lipophilic, benzalacetophenone, isoxazoline.

Graphical Abstract
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