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Cardiovascular & Hematological Agents in Medicinal Chemistry


ISSN (Print): 1871-5257
ISSN (Online): 1875-6182

Systematic Review Article

The Effect of Aspirin on the Prevention of Pro-thrombotic States in Hospitalized COVID-19 Patients: Systematic Review

(E-pub Ahead of Print)
Published on: 21 July, 2022
Author(s): Masoumeh Abdi, Zahra Hosseini, Fatemeh Shirjan, Leila Mohammadi, Sahel Shafiee Dolat Abadi, Nilofar Massoudi, Moein Zangiabadian* and Mohammad Javad Nasiri*

Introduction: Thromboembolic events are one of the important complications in COVID-19 patients, especially in severe cases. Aspirin affects platelet function by irreversibly inhibiting cyclooxygenase activity, reducing the risk of thrombosis. The current systematic review aimed to evaluate aspirin's effectiveness in preventing pro-thrombotic states in COVID-19 hospitalized patients.

Methods: The systematic search was done in PubMed/Medline, EMBASE, and Medrxiv until September 27, 2021. The following keywords were used: “COVID-19”, “SARS-CoV-2”, “2019 Novel Coronavirus”, “Aspirin,” and “Acetylsalicylic Acid.”

Results: Twelve studies were included. In COVID-19 patients, aspirin can reduce CRP, IL-6 levels, and platelet aggregation by inhibiting thromboxane A2. It can also improve antiviral immunity by hindering the biosynthesis of prostaglandins and lipoxin. Eight out of twelve articles indicated that aspirin provided a beneficial effect on COVID-19. Most studies consider lowered mechanical ventilation needs, ICU admission, illness severity, overt thrombosis, and clinical outcomes in COVID-19 patients receiving aspirin.

Conclusion: Aspirin as an antiplatelet and anti-inflammatory agent may reduce the mortality rates in hospitalized patients with severe COVID-19. Further observational studies are necessary to determine the effect of aspirin on the prevention of pro-thrombotic states in hospitalized COVID- 19 patients.

The study was registered in the Systematic Review Registration: PROSPERO (pending registration ID: 300515).

Keywords: Aspirin, acetylsalicylic acid, thrombosis, SARS-COV-2, COVID-19, pro-thrombotic.

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