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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Natural Bioactive Compounds from Medicinal Plants as Antibacterial Drugs: Mechanism Insights and Clinical Perspectives

Author(s): Nasreddine El Omari, Fatima-Ezzahrae Guaouguaou* and Abdelhakim Bouyahya

Volume 22, Issue 13, 2022

Published on: 12 May, 2022

Page: [1093 - 1103] Pages: 11

DOI: 10.2174/1568026622666220330011255

Price: $65


The coevolution in microbes has generated major functional consequences leading bacteria to develop resistance to antibiotics. Indeed, bacterial strains have been able to develop and adapt to the action of antibiotics via several resistance mechanisms. In this context, researchers are currently conducting many studies to screen natural antibacterial substances such as secondary metabolites of medicinal plants. Indeed, the potential of many plants used in traditional medicine in the treatment of infectious diseases was confirmed experimentally, namely Anethum graveolens, Elettaria cardamomum, Foeniculum vulgare, Trachyspermum ammi, Viola odorata, Dioscorea dregeana, Cheilanthes viridis, Vernonia colorata, etc. Bioactive molecules from different medicinal plants include terpenoids, flavonoids, and phenolic acids, which were shown to have significant anti- bacterial effects. The mechanisms of action of these molecules are different and can include structural, cellular, and molecular levels, which suggests them as real candidates for the development of natural antibiotics. However, the clinical trials of these molecules have not been very well studied which limits their clinical use against infectious diseases of bacterial origin.

Keywords: Antibiotic resistance, Natural substance, Antibacterial action, Bacteriostatic, Bactericide, Natural bioactive compounds, Medicinal plants.

Graphical Abstract
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