Abstract
The Wnt signaling pathway has important functions in development, tissue homeostasis, and regeneration. Deregulation of canonical Wnt/β-catenin signaling is frequently found in various human cancers, particularly in colorectal cancer, and non-canonical Wnt signaling pathways also have been implicated in neoplasia. Colorectal cancer is a multipathway disease. Activation of Wnt signaling by both genetic and epigenetic alterations has been found to be important for both, initiation and progression of colorectal cancer. In addition, since Wnt signaling results in diverse downstream intracellular events, targeted inhibition of Wnt/β-catenin signaling at the most upstream site of this pathway is a rational and an advantageous new approach for the therapy of colorectal cancer.
Call for Papers in Thematic Issues
Emerging Drug Targets and Revolutionary Therapeutic Approaches for Effective Anti-Cancer Intervention
Recent advancements in cancer research have significantly advanced our understanding of the intricate molecular mechanisms driving cancer progression, leading to the identification of new drug targets and therapeutic strategies. The elucidation of complex signaling pathways and genetic aberrations associated with tumorigenesis has provided valuable insights into potential targets for intervention. ...read more
From Models to Molecules: Integrative Strategies in Herbal Product-based Drug Discovery
The toxic effects of synthetic drugs underscore the complex equilibrium between their therapeutic efficacy and the potential hazards they pose to biological systems. Natural products, with their diverse bioactive compounds and natural synergism, can help counteract synthetic drug toxicities by offering a complementary multi-targeted approach to mitigate organ damage and ...read more
Multitarget Agents For Complex Diseases
The basic principle of action of a drug is based on model lock and key, where is desirable the highest possible affinity for a target avoiding no side effects. For many years it was desirable‘one drug for one target for one disease’, however the researchers observed that complex diseases are ...read more
New Drug Therapy for Eye Diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
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