Abstract
The current commentary describes the possible existing link between metabolic diseases such as diabetes type 2 and the degenerative patterns of bones via the molecular mechanism that inhibits the mesenchymal stem cells’ differentiation into osteoblasts and osteocytes.
Keywords: Diabetes type 1-2, regenerative medicine, enteric nervous system (ENS), central nervous system (CNS), mesenchymal stem cells (MSCs), bone marrow (BM), osteoblasts, ageing, bone decay.
[http://dx.doi.org/10.4239/wjd.v3.i6.110] [PMID: 22737281]
[http://dx.doi.org/10.7150/ijms.10001] [PMID: 25249787]
[http://dx.doi.org/10.5493/wjem.v7.i1.1] [PMID: 28261550]
[http://dx.doi.org/10.1159/000085954] [PMID: 16046865]
[http://dx.doi.org/10.1007/s00520-009-0703-6] [PMID: 19621246]
[http://dx.doi.org/10.1186/1758-5996-2-55] [PMID: 20718958]
[http://dx.doi.org/10.2337/db16-1444] [PMID: 28389469]
[http://dx.doi.org/10.3389/fmicb.2014.00190]
[http://dx.doi.org/10.1038/ctg.2015.16] [PMID: 26087059]
[http://dx.doi.org/10.4093/dmj.2015.39.3.198] [PMID: 26124989]
[http://dx.doi.org/10.1159/000364934] [PMID: 25341516]
[http://dx.doi.org/10.9734/BJMMR/2017/32206]
[http://dx.doi.org/10.1056/NEJMcibr1112347] [PMID: 22204729]
[http://dx.doi.org/10.1177/1474651413502684]
[http://dx.doi.org/10.1152/ajpcell.00380.2011] [PMID: 22159079]
[http://dx.doi.org/10.1146/annurev.physiol.010908.163145] [PMID: 18808327]
[http://dx.doi.org/10.1161/CIRCRESAHA.109.213140] [PMID: 20299675]
[http://dx.doi.org/10.1016/S0140-6736(12)60572-8] [PMID: 22717317]
[http://dx.doi.org/10.3748/wjg.v20.i43.16079] [PMID: 25473159]
[http://dx.doi.org/10.1084/jem.20091568] [PMID: 20026663]
[http://dx.doi.org/10.1007/s11914-007-0024-y] [PMID: 17925190]
[PMID: 29047262]
[http://dx.doi.org/10.3389/fimmu.2014.00491] [PMID: 25339958]
[http://dx.doi.org/10.1111/dme.13977] [PMID: 31006133]
[http://dx.doi.org/10.1155/2020/4732021] [PMID: 33061966]
[http://dx.doi.org/10.3389/fimmu.2014.00511] [PMID: 25368616]
[http://dx.doi.org/10.1210/js.2018-00426] [PMID: 31403089]
[http://dx.doi.org/10.1016/j.joca.2015.03.014] [PMID: 26521745]
[http://dx.doi.org/10.3389/fimmu.2021.578386] [PMID: 33717063]
[http://dx.doi.org/10.3389/fimmu.2021.702955] [PMID: 34394099]
[http://dx.doi.org/10.1146/annurev.immunol.24.021605.090646]
[PMID: 24089220]
[http://dx.doi.org/10.2302/kjm.54.55] [PMID: 16077253]
[http://dx.doi.org/10.1194/jlr.R045559] [PMID: 24489112]
[http://dx.doi.org/10.11138/ccmbm/2017.14.1.200] [PMID: 29263734]
[http://dx.doi.org/10.2215/CJN.00770208] [PMID: 18495950]
[http://dx.doi.org/10.1161/01.ATV.18.9.1400] [PMID: 9743228]
[http://dx.doi.org/10.1097/MD.0000000000002895] [PMID: 26962786]
[http://dx.doi.org/10.4161/19381972.2014.968490] [PMID: 26413183]
[http://dx.doi.org/10.1089/ars.2006.8.347] [PMID: 16677080]
[http://dx.doi.org/10.1160/TH09-03-0204] [PMID: 19492146]
[http://dx.doi.org/10.1128/MCB.00020-14] [PMID: 24509263]
[http://dx.doi.org/10.1089/ten.teb.2016.0454] [PMID: 27846781]
[http://dx.doi.org/10.1023/A:1013360308946] [PMID: 11855740]
[http://dx.doi.org/10.3164/jcbn.13-25] [PMID: 24062608]
[http://dx.doi.org/10.1016/j.clnu.2010.02.010] [PMID: 20332058]
[http://dx.doi.org/10.15761/IMM.1000101]
[http://dx.doi.org/10.1039/C5FO00544B] [PMID: 26267519]
[http://dx.doi.org/10.3945/ajcn.113.070086] [PMID: 24284439]
[http://dx.doi.org/10.1038/nrm3522] [PMID: 23361334]
[http://dx.doi.org/10.1152/ajpregu.00262.2014] [PMID: 25253086]
[http://dx.doi.org/10.1111/acel.12015] [PMID: 23061800]
[http://dx.doi.org/10.1038/nrg1879] [PMID: 16847462]
[http://dx.doi.org/10.1146/annurev.pathol.4.110807.092311] [PMID: 18767981]
[http://dx.doi.org/10.1038/nature02866] [PMID: 15306821]
[http://dx.doi.org/10.1016/j.cell.2013.07.031] [PMID: 23953116]
[http://dx.doi.org/10.1186/1743-7075-9-74] [PMID: 22891897]
[http://dx.doi.org/10.1038/ncomms8940] [PMID: 26268630]
[http://dx.doi.org/10.5483/BMBRep.2017.50.12.206] [PMID: 29187279]
[http://dx.doi.org/10.1042/CS20171158]
[http://dx.doi.org/10.1002/jcb.25728] [PMID: 27606668]
[http://dx.doi.org/10.1007/s00125-015-3632-6] [PMID: 26037201]
[http://dx.doi.org/10.1371/journal.pgen.1004145] [PMID: 24497849]
[http://dx.doi.org/10.1172/JCI78470] [PMID: 25562323]
[PMID: 26657771]
[PMID: 21036700]
[PMID: 26435639]
[http://dx.doi.org/10.1152/physrev.00012.2004] [PMID: 15788704]
[http://dx.doi.org/10.5966/sctm.2012-0064] [PMID: 23197668]