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Anti-Cancer Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Review Article

Drug Repurposing Strategies for Non-cancer to Cancer Therapeutics

Author(s): Shipra Singhal, Priyal Maheshwari, Praveen Thaggikuppe Krishnamurthy and Vaishali M. Patil*

Volume 22, Issue 15, 2022

Published on: 12 May, 2022

Page: [2726 - 2756] Pages: 31

DOI: 10.2174/1871520622666220317140557

Price: $65

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Abstract

Global efforts invested in the prevention and treatment of cancer need to be repositioned to develop safe, effective, and economic anticancer therapeutics by adopting rational approaches of drug discovery. Drug repurposing is one of the established approaches to reposition old, clinically approved off-patent noncancer drugs with known targets into newer indications. The literature review suggests a key role of drug repurposing in the development of drugs intended for cancer as well as noncancer therapeutics. A wide category of noncancer drugs such as, drugs acting on CNS, anthelmintics, cardiovascular drugs, antimalarial drugs, anti-inflammatory drugs, have come out with interesting outcomes during preclinical and clinical phases. In the present article, a comprehensive overview of the current scenario of drug repurposing for the treatment of cancer has been focused. The details of some successful studies along with examples have been included followed by associated challenges.

Keywords: Anticancer drugs, multitargeting, Non-cancer drugs, drug repurposing, drug discovery, cancer therapeutics.

Graphical Abstract
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