Abstract
Global efforts invested in the prevention and treatment of cancer need to be repositioned to develop safe, effective, and economic anticancer therapeutics by adopting rational approaches of drug discovery. Drug repurposing is one of the established approaches to reposition old, clinically approved off-patent noncancer drugs with known targets into newer indications. The literature review suggests a key role of drug repurposing in the development of drugs intended for cancer as well as noncancer therapeutics. A wide category of noncancer drugs such as, drugs acting on CNS, anthelmintics, cardiovascular drugs, antimalarial drugs, anti-inflammatory drugs, have come out with interesting outcomes during preclinical and clinical phases. In the present article, a comprehensive overview of the current scenario of drug repurposing for the treatment of cancer has been focused. The details of some successful studies along with examples have been included followed by associated challenges.
Keywords: Anticancer drugs, multitargeting, Non-cancer drugs, drug repurposing, drug discovery, cancer therapeutics.
[http://dx.doi.org/10.1016/j.drudis.2015.05.001] [PMID: 25975957]
[http://dx.doi.org/10.7150/ijbs.9224] [PMID: 25013375]
[http://dx.doi.org/10.1111/cas.14318] [PMID: 31957175]
[http://dx.doi.org/10.1111/bph.13798] [PMID: 28369768]
[http://dx.doi.org/10.3332/ecancer.2014.485] [PMID: 25075216]
[http://dx.doi.org/10.1038/s41467-021-21330-0] [PMID: 33589615]
[http://dx.doi.org/10.1016/j.tips.2021.01.003] [PMID: 33563480]
[http://dx.doi.org/10.3389/frym.2020.553424]
[PMID: 34746987]
[http://dx.doi.org/10.1080/17460441.2020.1704729] [PMID: 31847616]
[http://dx.doi.org/10.3389/fonc.2020.605680] [PMID: 33520715]
[http://dx.doi.org/10.1038/s41571-019-0252-y] [PMID: 31399699]
[http://dx.doi.org/10.5858/arpa.2018-0147-OA] [PMID: 30295070]
[http://dx.doi.org/10.1038/s41571-019-0273-6] [PMID: 31619755]
[http://dx.doi.org/10.1371/journal.pone.0218642] [PMID: 31577805]
[http://dx.doi.org/10.1093/bioinformatics/btz465] [PMID: 31173067]
[http://dx.doi.org/10.1038/s41392-020-00213-8] [PMID: 32616710]
[http://dx.doi.org/10.1016/j.semcancer.2019.12.011] [PMID: 31904426]
[http://dx.doi.org/10.1016/j.semcancer.2015.09.007] [PMID: 26590477]
[http://dx.doi.org/10.1126/science.aal2380] [PMID: 28729483]
[http://dx.doi.org/10.1016/j.drup.2019.100646] [PMID: 31733611]
[http://dx.doi.org/10.4236/jct.2015.610093]
[http://dx.doi.org/10.1016/j.bmcl.2019.04.045] [PMID: 31054863]
[PMID: 10676625]
[http://dx.doi.org/10.1080/15384101.2016.1241929] [PMID: 27753527]
[PMID: 19846942]
[http://dx.doi.org/10.1371/journal.pone.0178493] [PMID: 28558025]
[http://dx.doi.org/10.1016/j.ejmech.2019.01.034] [PMID: 30684870]
[http://dx.doi.org/10.1177/1010428317695035] [PMID: 28349817]
[http://dx.doi.org/10.1016/j.tet.2018.07.028]
[http://dx.doi.org/10.15557/CGO.2016.0018]
[http://dx.doi.org/10.1016/j.ejmech.2017.06.030] [PMID: 28651817]
[http://dx.doi.org/10.1016/j.canep.2013.02.008] [PMID: 23545383]
[PMID: 23564786]
[http://dx.doi.org/10.3892/ijo.22.4.855] [PMID: 12632079]
[http://dx.doi.org/10.3892/ijo.22.2.377] [PMID: 12527937]
[http://dx.doi.org/10.3892/ijo.23.1.197] [PMID: 12792794]
[http://dx.doi.org/10.1002/ijc.10592] [PMID: 12209973]
[http://dx.doi.org/10.1046/j.1365-2141.2002.03834.x] [PMID: 12406077]
[http://dx.doi.org/10.4046/trd.2013.75.1.9] [PMID: 23946753]
[http://dx.doi.org/10.1038/s41598-018-38019-y] [PMID: 30718715]
[PMID: 29511601]
[http://dx.doi.org/10.15252/emmm.201404084] [PMID: 25143352]
[http://dx.doi.org/10.3892/mmr.2017.8231] [PMID: 29257278]
[http://dx.doi.org/10.1158/1535-7163.MCT-14-0980-T] [PMID: 26078298]
[http://dx.doi.org/10.18632/oncotarget.22587] [PMID: 29296196]
[http://dx.doi.org/10.1016/j.lab.2003.12.012] [PMID: 15085079]
[PMID: 20036604]
[http://dx.doi.org/10.2174/1871520617666170213111951] [PMID: 28270076]
[http://dx.doi.org/10.1158/1535-7163.MCT-13-1060] [PMID: 25277383]
[http://dx.doi.org/10.18632/oncotarget.15166] [PMID: 28187433]
[http://dx.doi.org/10.2174/1871520615666150101130209] [PMID: 25553435]
[http://dx.doi.org/10.1111/j.1747-0285.2011.01287.x] [PMID: 22145602]
[http://dx.doi.org/10.1016/j.ejmech.2018.12.057] [PMID: 30611056]
[http://dx.doi.org/10.1021/acscentsci.8b00257] [PMID: 29974072]
[http://dx.doi.org/10.1186/s12885-016-2142-3] [PMID: 26906175]
[http://dx.doi.org/10.1038/nchem.2778] [PMID: 28937680]
[http://dx.doi.org/10.1016/j.ejmech.2014.02.031] [PMID: 24602789]
[http://dx.doi.org/10.1016/j.ejmech.2015.01.045] [PMID: 25644674]
[http://dx.doi.org/10.1016/j.molstruc.2006.07.043]
[http://dx.doi.org/10.1038/srep17523] [PMID: 26639992]
[http://dx.doi.org/10.1093/carcin/bgt137] [PMID: 23615398]
[http://dx.doi.org/10.1016/j.biomaterials.2017.12.018] [PMID: 29304403]
[http://dx.doi.org/10.1038/s41598-018-36214-5] [PMID: 30559409]
[http://dx.doi.org/10.1158/1078-0432.CCR-09-1035] [PMID: 19789329]
[http://dx.doi.org/10.1158/1535-7163.MCT-10-0368] [PMID: 21159605]
[http://dx.doi.org/10.2174/138920112800399095] [PMID: 22039784]
[http://dx.doi.org/10.33549/physiolres.932711] [PMID: 24564661]
[http://dx.doi.org/10.1158/0008-5472.CAN-15-2887] [PMID: 27302166]
[PMID: 22495656]
[http://dx.doi.org/10.1016/j.phrs.2020.105207] [PMID: 32971268]
[http://dx.doi.org/10.4081/oncol.2019.411] [PMID: 31044029]
[http://dx.doi.org/10.1016/j.ejmech.2017.04.028] [PMID: 28427017]
[http://dx.doi.org/10.1038/srep27540] [PMID: 27277973]
[http://dx.doi.org/10.1158/1535-7163.MCT-16-0169-T] [PMID: 28062709]
[http://dx.doi.org/10.1164/rccm.201207-1180OC] [PMID: 23024022]
[http://dx.doi.org/10.1124/mol.114.096941] [PMID: 25552486]
[http://dx.doi.org/10.1074/jbc.RA117.000162] [PMID: 29321207]
[http://dx.doi.org/10.18632/oncotarget.4307] [PMID: 26061710]
[http://dx.doi.org/10.1080/15548627.2015.1082024] [PMID: 26735433]
[http://dx.doi.org/10.1177/1947601912466555] [PMID: 23264850]
[http://dx.doi.org/10.1016/j.canlet.2011.07.015] [PMID: 21862211]
[http://dx.doi.org/10.1002/hed.21734] [PMID: 21438066]
[http://dx.doi.org/10.18632/oncotarget.14716] [PMID: 28108734]
[http://dx.doi.org/10.3390/ijms19010164] [PMID: 29304031]
[http://dx.doi.org/10.1634/theoncologist.2011-0031] [PMID: 21632454]
[http://dx.doi.org/10.1002/2211-5463.12223] [PMID: 28593135]
[http://dx.doi.org/10.3390/ijms18051048] [PMID: 28498322]
[http://dx.doi.org/10.18632/oncotarget.6802] [PMID: 26735339]
[http://dx.doi.org/10.1074/jbc.M109.057836] [PMID: 20145244]
[http://dx.doi.org/10.1126/scitranslmed.3003016] [PMID: 22461640]
[http://dx.doi.org/10.1016/j.ccell.2015.08.012] [PMID: 26412325]
[http://dx.doi.org/10.1158/1078-0432.CCR-15-2535] [PMID: 26927663]
[http://dx.doi.org/10.1038/onc.2015.291] [PMID: 26257063]
[http://dx.doi.org/10.1158/1535-7163.MCT-13-0688] [PMID: 24482381]
[http://dx.doi.org/10.1038/s41598-017-04796-1] [PMID: 28667329]
[http://dx.doi.org/10.18632/oncotarget.10541] [PMID: 27438151]
[http://dx.doi.org/10.1182/blood-2002-07-2044] [PMID: 12515726]
[PMID: 18636148]
[http://dx.doi.org/10.3389/fphar.2016.00334] [PMID: 27713700]
[http://dx.doi.org/10.1016/j.humpath.2011.10.010] [PMID: 22245111]
[http://dx.doi.org/10.1186/2045-3701-4-45] [PMID: 25949794]
[http://dx.doi.org/10.1016/j.mehy.2012.03.026] [PMID: 22543071]
[http://dx.doi.org/10.1016/j.cell.2012.03.049] [PMID: 22632761]
[http://dx.doi.org/10.1007/s00280-003-0738-1] [PMID: 14663628]
[http://dx.doi.org/10.1385/JMN:22:3:189] [PMID: 14997012]
[http://dx.doi.org/10.1038/cddis.2014.56] [PMID: 24625970]
[http://dx.doi.org/10.1038/s41598-018-19413-y] [PMID: 29348654]
[http://dx.doi.org/10.1124/mol.62.2.210] [PMID: 12130671]
[http://dx.doi.org/10.1093/carcin/bgt019] [PMID: 23349020]
[http://dx.doi.org/10.1158/1535-7163.MCT-17-0074] [PMID: 28802253]
[http://dx.doi.org/10.1097/WNR.0000000000000448] [PMID: 26339990]
[http://dx.doi.org/10.1186/s12885-016-2957-y] [PMID: 27884140]
[http://dx.doi.org/10.1093/neuonc/nop005] [PMID: 20308311]
[http://dx.doi.org/10.1016/j.canlet.2011.12.041] [PMID: 22261333]
[http://dx.doi.org/10.1186/1868-7083-5-13] [PMID: 23915396]
[http://dx.doi.org/10.1002/emmm.201302796] [PMID: 24092664]
[http://dx.doi.org/10.1158/2159-8290.CD-13-0183] [PMID: 24078773]
[PMID: 20811727]
[http://dx.doi.org/10.18632/oncotarget.19843] [PMID: 29212279]
[http://dx.doi.org/10.3906/biy-1802-11]
[http://dx.doi.org/10.7150/oncm.20563]
[http://dx.doi.org/10.1016/S1090-0233(05)80005-X] [PMID: 9265850]
[http://dx.doi.org/10.1371/journal.pone.0070702] [PMID: 23869246]
[http://dx.doi.org/10.1111/j.1349-7006.2004.tb03330.x] [PMID: 15298733]
[PMID: 12231542]
[http://dx.doi.org/10.1016/j.trecan.2017.04.008] [PMID: 28670628]
[http://dx.doi.org/10.1158/1541-7786.MCR-07-2159] [PMID: 18667591]
[http://dx.doi.org/10.1016/j.tiv.2015.08.007] [PMID: 26315676]
[http://dx.doi.org/10.1227/01.neu.0000460594.93803.cb]
[http://dx.doi.org/10.1093/neuonc/nor077] [PMID: 21764822]
[http://dx.doi.org/10.1182/blood-2009-09-243055] [PMID: 20348394]
[http://dx.doi.org/10.18632/oncotarget.3436] [PMID: 25811972]
[http://dx.doi.org/10.1158/1535-7163.MCT-14-0755-T] [PMID: 25376612]
[http://dx.doi.org/10.18632/oncotarget.14673] [PMID: 28099902]
[http://dx.doi.org/10.18632/oncotarget.14990] [PMID: 28157711]
[http://dx.doi.org/10.1038/srep33534] [PMID: 27650168]
[http://dx.doi.org/10.18632/oncotarget.11851] [PMID: 27612418]
[http://dx.doi.org/10.1007/s13277-015-4650-1] [PMID: 26810188]
[http://dx.doi.org/10.1016/j.mrfmmm.2014.05.005] [PMID: 25847384]
[http://dx.doi.org/10.1186/s12876-016-0442-3] [PMID: 26917416]
[http://dx.doi.org/10.1158/1078-0432.CCR-12-2895] [PMID: 23908450]
[http://dx.doi.org/10.1158/0008-5472.CAN-09-3950] [PMID: 20215516]
[http://dx.doi.org/10.1016/j.biopha.2014.03.018] [PMID: 24750999]
[http://dx.doi.org/10.1002/pros.23015] [PMID: 25970160]
[http://dx.doi.org/10.1016/j.bbrc.2017.01.140] [PMID: 28137584]
[http://dx.doi.org/10.1158/1078-0432.CCR-15-2256] [PMID: 26873959]
[http://dx.doi.org/10.1371/journal.pone.0074538] [PMID: 24058587]
[http://dx.doi.org/10.18632/oncotarget.7113] [PMID: 26848771]
[http://dx.doi.org/10.1158/1535-7163.MCT-12-0002] [PMID: 22576131]
[http://dx.doi.org/10.1016/j.ygyno.2014.04.005] [PMID: 24736023]
[http://dx.doi.org/10.18632/oncotarget.13466] [PMID: 27888804]
[http://dx.doi.org/10.1016/j.canlet.2014.04.003] [PMID: 24732808]
[http://dx.doi.org/10.5732/cjc.011.10290] [PMID: 22237038]
[http://dx.doi.org/10.18632/oncotarget.11318] [PMID: 27542212]
[http://dx.doi.org/10.18632/oncotarget.16252] [PMID: 28418862]
[http://dx.doi.org/10.2147/OTT.S129449] [PMID: 28367059]
[http://dx.doi.org/10.1016/j.clinre.2011.03.015] [PMID: 21782548]
[http://dx.doi.org/10.1007/s00384-014-1975-y] [PMID: 25060218]
[http://dx.doi.org/10.1371/journal.pone.0071508] [PMID: 24013655]
[http://dx.doi.org/10.1016/j.bbrc.2015.12.059] [PMID: 26707639]
[http://dx.doi.org/10.1371/journal.pone.0101969] [PMID: 25003333]
[http://dx.doi.org/10.12659/MSM.901667] [PMID: 28090074]
[http://dx.doi.org/10.3892/ijo.2016.3337] [PMID: 26781188]
[PMID: 25960639]
[http://dx.doi.org/10.1158/0008-5472.CAN-14-0317] [PMID: 24994715]
[http://dx.doi.org/10.18632/oncotarget.5615] [PMID: 26378050]
[http://dx.doi.org/10.1158/1078-0432.CCR-14-3147] [PMID: 26152745]
[http://dx.doi.org/10.1038/cddis.2013.142] [PMID: 23640456]
[http://dx.doi.org/10.1371/journal.pone.0003951] [PMID: 19079611]
[http://dx.doi.org/10.1007/BF00613522] [PMID: 3816925]
[http://dx.doi.org/10.1007/s00280-007-0538-0] [PMID: 17581752]
[PMID: 12479701]
[http://dx.doi.org/10.3332/ecancer.2014.485] [PMID: 25075217]
[http://dx.doi.org/10.1371/journal.pone.0124595] [PMID: 25897961]
[http://dx.doi.org/10.2174/1568009615666150629132157] [PMID: 26118906]
[http://dx.doi.org/10.1007/s00011-015-0888-8] [PMID: 26499405]
[http://dx.doi.org/10.1371/journal.pone.0079374] [PMID: 24223934]
[http://dx.doi.org/10.18632/oncotarget.3174] [PMID: 25625193]
[http://dx.doi.org/10.3389/fonc.2012.00137] [PMID: 23061049]
[http://dx.doi.org/10.1093/jb/mvs041] [PMID: 22528668]
[http://dx.doi.org/10.1016/j.canlet.2011.12.034] [PMID: 22210382]
[http://dx.doi.org/10.1158/0008-5472.CAN-19-1184]
[http://dx.doi.org/10.2119/molmed.2017.00011] [PMID: 28386621]
[http://dx.doi.org/10.1021/cb400759d] [PMID: 24354286]
[http://dx.doi.org/10.3390/molecules21101331] [PMID: 27739410]
[http://dx.doi.org/10.1371/journal.pone.0037222] [PMID: 22666346]
[http://dx.doi.org/10.1158/1535-7163.MCT-11-0534] [PMID: 21998290]
[http://dx.doi.org/10.1074/jbc.M110.144188] [PMID: 21059641]
[http://dx.doi.org/10.2174/138945006776359412] [PMID: 16611029]
[http://dx.doi.org/10.1016/j.canlet.2008.09.023] [PMID: 19006645]
[http://dx.doi.org/10.4161/cbt.7.7.6035] [PMID: 18414062]
[http://dx.doi.org/10.1097/CAD.0b013e328350e8ac] [PMID: 22421370]
[http://dx.doi.org/10.18632/oncotarget.10367] [PMID: 27385212]
[http://dx.doi.org/10.1016/j.canlet.2010.01.001] [PMID: 20137856]
[http://dx.doi.org/10.1007/s11010-011-0716-6] [PMID: 21234653]
[http://dx.doi.org/10.1111/ejh.12176] [PMID: 23869695]
[http://dx.doi.org/10.1111/j.1745-7254.2007.00612.x] [PMID: 17588342]
[http://dx.doi.org/10.1007/s00432-009-0731-0] [PMID: 19941148]
[http://dx.doi.org/10.1186/1756-9966-33-8] [PMID: 24438216]
[http://dx.doi.org/10.1186/s12936-016-1443-y] [PMID: 27449110]
[http://dx.doi.org/10.1007/s00280-011-1643-7] [PMID: 21479633]
[http://dx.doi.org/10.4161/15384047.2014.955728] [PMID: 25482945]
[http://dx.doi.org/10.3892/etm.2014.1997] [PMID: 25371719]
[PMID: 25862844]
[http://dx.doi.org/10.2174/156800909787314020] [PMID: 19200051]
[http://dx.doi.org/10.3390/molecules161210556] [PMID: 22183882]
[http://dx.doi.org/10.1016/j.ejphar.2008.03.041] [PMID: 18448095]
[http://dx.doi.org/10.1186/s12967-016-1031-5] [PMID: 27646033]
[http://dx.doi.org/10.1016/S0022-5347(17)34918-2] [PMID: 8254815]
[http://dx.doi.org/10.1016/S0304-3835(96)04449-7] [PMID: 9018076]
[http://dx.doi.org/10.1016/S0014-5793(01)02377-8] [PMID: 11334891]
[http://dx.doi.org/10.1158/1078-0432.CCR-04-1946] [PMID: 15814650]
[http://dx.doi.org/10.1016/j.ygyno.2008.02.019] [PMID: 18395779]
[http://dx.doi.org/10.1007/s00280-009-1136-0] [PMID: 19771429]
[http://dx.doi.org/10.3892/ijo_00000776] [PMID: 20878072]
[http://dx.doi.org/10.1007/s11605-007-0403-9] [PMID: 18026817]
[http://dx.doi.org/10.2174/1871520620999201117111139] [PMID: 33208079]
[http://dx.doi.org/10.1007/s00432-004-0582-7] [PMID: 15449186]
[PMID: 5589524]
[http://dx.doi.org/10.1111/j.1749-6632.1997.tb52341.x] [PMID: 9405883]
[http://dx.doi.org/10.1002/cncr.11267] [PMID: 12673711]
[http://dx.doi.org/10.1016/S0022-5347(05)68629-6] [PMID: 10411090]
[http://dx.doi.org/10.1093/oxfordjournals.jbchem.a022446] [PMID: 10423518]
[http://dx.doi.org/10.1007/s10495-006-0626-3] [PMID: 17203245]
[PMID: 10919658]
[http://dx.doi.org/10.1248/bpb.29.1493] [PMID: 16819197]
[http://dx.doi.org/10.1016/S0140-6736(79)90996-6] [PMID: 85158]
[http://dx.doi.org/10.1056/NEJM198202253060813] [PMID: 7057849]
[http://dx.doi.org/10.3892/or.6.3.493] [PMID: 10203580]
[http://dx.doi.org/10.1186/1471-2407-1-11] [PMID: 11532201]
[http://dx.doi.org/10.1186/bcr2205] [PMID: 19055760]
[http://dx.doi.org/10.1200/JCO.2010.32.8146] [PMID: 21422417]
[http://dx.doi.org/10.1002/ijc.26424] [PMID: 21913187]
[http://dx.doi.org/10.1158/2159-8274.CD-10-0020] [PMID: 22140654]
[http://dx.doi.org/10.1038/nrc1751] [PMID: 16341084]
[http://dx.doi.org/10.1111/j.1572-0241.2007.01773.x] [PMID: 18371146]
[PMID: 19360310]
[http://dx.doi.org/10.1093/carcin/22.8.1139] [PMID: 11470741]
[http://dx.doi.org/10.1200/JCO.2004.02.027] [PMID: 15197200]
[http://dx.doi.org/10.1001/archinte.160.15.2363] [PMID: 10927735]
[http://dx.doi.org/10.1371/journal.pone.0046691] [PMID: 23049713]
[http://dx.doi.org/10.1016/j.cgh.2012.12.036] [PMID: 23357487]
[http://dx.doi.org/10.1007/s00228-013-1547-z] [PMID: 23748751]
[http://dx.doi.org/10.1371/journal.pone.0029849] [PMID: 22276132]
[http://dx.doi.org/10.1371/journal.pone.0057349] [PMID: 23468972]
[http://dx.doi.org/10.1038/bjc.2013.762] [PMID: 24366301]
[http://dx.doi.org/10.1182/blood-2006-08-044446] [PMID: 17158228]
[http://dx.doi.org/10.1159/000156702] [PMID: 18797167]
[http://dx.doi.org/10.1016/j.clon.2015.10.004] [PMID: 26520788]
[http://dx.doi.org/10.1002/ijc.30458] [PMID: 27706811]
[http://dx.doi.org/10.1136/gut.50.6.857] [PMID: 12010890]
[http://dx.doi.org/10.1056/NEJM200006293422603] [PMID: 10874062]
[http://dx.doi.org/10.1007/s00259-007-0563-6] [PMID: 17786437]
[http://dx.doi.org/10.1158/1940-6207.CAPR-08-0081] [PMID: 19138981]
[http://dx.doi.org/10.1056/NEJM199305063281805] [PMID: 8385741]
[http://dx.doi.org/10.1186/s12885-017-3757-8] [PMID: 29137605]
[http://dx.doi.org/10.1126/science.1096502] [PMID: 15016963]
[http://dx.doi.org/10.1002/emmm.200900039] [PMID: 20049737]
[http://dx.doi.org/10.1073/pnas.0700776104] [PMID: 17392427]
[http://dx.doi.org/10.1152/ajpcell.00196.2016] [PMID: 27903583]
[http://dx.doi.org/10.1126/science.1235122] [PMID: 23539594]
[http://dx.doi.org/10.1126/science.1145720] [PMID: 17932254]
[http://dx.doi.org/10.1136/gutjnl-2014-307235] [PMID: 25792707]
[http://dx.doi.org/10.1056/NEJMoa050493] [PMID: 15713943]
[http://dx.doi.org/10.1056/NEJMoa071841] [PMID: 17652651]
[http://dx.doi.org/10.1038/nm.3787] [PMID: 25849133]
[http://dx.doi.org/10.1038/onc.2012.181] [PMID: 22665053]
[http://dx.doi.org/10.3389/fendo.2018.00622] [PMID: 30405532]
[http://dx.doi.org/10.1111/j.1349-7006.2008.00933.x] [PMID: 18803638]
[http://dx.doi.org/10.1002/mc.20637] [PMID: 20564343]
[http://dx.doi.org/10.20892/j.issn.2095-3941.2016.0088] [PMID: 28443209]
[http://dx.doi.org/10.1186/1471-2407-12-118] [PMID: 22443173]
[http://dx.doi.org/10.1007/s10689-016-9901-9] [PMID: 27083160]
[http://dx.doi.org/10.1001/jama.2016.2522] [PMID: 27002448]
[http://dx.doi.org/10.1158/1940-6207.CAPR-08-0042] [PMID: 18841250]
[http://dx.doi.org/10.1001/jama.2009.1112] [PMID: 19671906]
[http://dx.doi.org/10.1056/NEJMoa1207756] [PMID: 23094721]
[http://dx.doi.org/10.1186/s13063-016-1744-z] [PMID: 28143522]
[http://dx.doi.org/10.1038/sj.onc.1204123] [PMID: 11313997]
[http://dx.doi.org/10.1186/s13046-015-0199-5] [PMID: 26260344]
[http://dx.doi.org/10.1038/nature25016] [PMID: 29211715]
[http://dx.doi.org/10.1158/1078-0432.CCR-1576-03] [PMID: 14760088]
[PMID: 12894507]
[http://dx.doi.org/10.1111/j.1440-1746.2006.04797.x] [PMID: 17376054]
[PMID: 12154013]
[http://dx.doi.org/10.1093/carcin/24.3.443] [PMID: 12663503]
[http://dx.doi.org/10.1016/j.ejca.2006.03.030] [PMID: 16914308]
[http://dx.doi.org/10.1155/2012/980458] [PMID: 22701310]
[http://dx.doi.org/10.1111/j.1445-2197.1994.tb04562.x] [PMID: 7980260]
[http://dx.doi.org/10.1038/sj.bjc.6600048] [PMID: 11870500]
[http://dx.doi.org/10.2165/00003495-199345050-00011] [PMID: 7686469]
[http://dx.doi.org/10.1038/nrmicro2783] [PMID: 22565131]
[http://dx.doi.org/10.3390/ijms15069173] [PMID: 24964007]
[http://dx.doi.org/10.1136/jclinpath-2013-202089] [PMID: 25016529]
[http://dx.doi.org/10.1371/journal.pone.0029950] [PMID: 22238681]
[http://dx.doi.org/10.1073/pnas.1413299111] [PMID: 25097266]
[http://dx.doi.org/10.3892/ijmm.2015.2289] [PMID: 26201988]
[http://dx.doi.org/10.1086/318452] [PMID: 11170912]
[http://dx.doi.org/10.1007/s00280-020-04216-8] [PMID: 33426580]
[http://dx.doi.org/10.3332/ecancer.2016.610] [PMID: 26823679]
[http://dx.doi.org/10.1371/journal.pone.0012715] [PMID: 20856806]
[PMID: 9134996]
[http://dx.doi.org/10.2337/dc10-0666] [PMID: 20587728]
[http://dx.doi.org/10.1038/ncomms8138] [PMID: 26151821]
[http://dx.doi.org/10.5306/wjco.v3.i12.150] [PMID: 23293754]
[http://dx.doi.org/10.2174/1570161043385556] [PMID: 15320819]
[http://dx.doi.org/10.1159/000330169] [PMID: 21849810]
[http://dx.doi.org/10.1007/s10585-014-9635-8] [PMID: 24442969]
[http://dx.doi.org/10.1159/000362092] [PMID: 25138435]
[http://dx.doi.org/10.3109/00365529009091915] [PMID: 1972297]
[http://dx.doi.org/10.3332/ecancer.2014.485] [PMID: 25525463]
[PMID: 10919677]
[http://dx.doi.org/10.1016/S0140-6736(95)92136-2] [PMID: 7603185]