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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Black Phosphorous Aptamer-based Platform for Biomarker Detection

Author(s): Ajinkya Nene, Shengyong Geng, Wenhua Zhou*, Xue-Feng Yu, Hongrong Luo and Seeram Ramakrishna

Volume 30, Issue 8, 2023

Published on: 01 April, 2022

Page: [935 - 952] Pages: 18

DOI: 10.2174/0929867329666220225110302

Price: $65


Black phosphorus nanostructures (nano-BPs) mainly include BP nanosheets (BP NSs), BP quantum dots (BPQDs), and other nano-BPs-based particles at nanoscale. Firstly discovered in 2014, nano-BPs are one of the most popular nanomaterials. Different synthesis methods are discussed in short to understand the basic concepts and developments in synthesis. Exfoliated nano-BPs, i.e. nano-BPs possess high surface area, high photothermal conversion efficacy, excellent biocompatibility, high charge carrier mobility (~1000 cm-2V-1s-1), thermal conductivity of 86 Wm-1K-1; and these properties make it a highly potential candidate for fabrication of biosensing platform. These properties enable nano-BPs to be promising photothermal/drug delivery agents as well as in electrochemical data storage devices and sensing devices; and in super capacitors, photodetectors, photovoltaics and solar cells, LEDs, super-conductors, etc. Early diagnosis is very critical in the health sector scenarios. This review attempts to highlight the attempts made towards attaining stable BP, BP-aptamer conjugates for successful biosensing applications. BP-aptamer- based platforms are reviewed to highlight the significance of BP in detecting biological and physiological markers of cardiovascular diseases and cancer; to be useful in disease diagnosis and management.

Keywords: Black phosphorous, stability, cardiovascular disorders, bio-sensing, aptamer, biomarkers.

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