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ISSN (Print): 2665-9786
ISSN (Online): 2665-9794

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Research Article

Role of Natural Plant Products Against Hemagglutinin-esterase (HE) of Human Coronavirus

Author(s): Mantasha I., Mohd. Shahid, Falaq Naz and Yasir Hasan Siddique*

Volume 3, Issue 2, 2022

Published on: 10 May, 2022

Article ID: e230222201366 Pages: 23

DOI: 10.2174/2665978603666220223093343

Price: $65

Abstract

Background: COVID-19 has spread worldwide and become a great cause of economic and social loss. Due to the non-availability of effective medicine/drug, its control has become a difficult task.

Objective: In the present study, the effect of some selected natural plant products was studied on the Hemagglutinin-esterase of the human coronavirus by performing molecular docking.

Methods: Molecular docking study for some selected natural plant products against Hemagglutininesterase (HE) of human coronavirus was performed using the HEX 8.0.0 software.

Results: The free binding energy ranged from -298.14 to -161, with that of curcumin being the highest.

Conclusions: The results suggest that the natural plant products could act as possible anti-viral agents and may be used as natural therapeutic agents.

Keywords: Coronavirus, natural plant products, molecular docking, hemagglutinin-esterase, non-covalent interactions, proteinligand.

Graphical Abstract

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