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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Mini-Review Article

The Antibacterial Activity of Natural-derived Flavonoids

Author(s): Zhenyou Tan*, Jun Deng, Qiongxian Ye and Zhenfeng Zhang

Volume 22, Issue 12, 2022

Published on: 07 March, 2022

Page: [1009 - 1019] Pages: 11

DOI: 10.2174/1568026622666220221110506

Price: $65


Flavonoids, a wide variety of phenolic secondary metabolites, are found in almost all plant families in the leaves, stems, roots, flowers, and seeds. Flavonoids could exert antibacterial activity via damaging the cytoplasmic membrane, inhibiting energy metabolism, and inhibiting the synthesis of nucleic acids, so flavonoids are considered constitutive antibacterial substances. This review aims to outline the recent advances of natural-derived flavonoids, including flavonoid glycosides with antibacterial potential to provide novel antibacterial lead hits/candidates, covering articles published between January 2016 and July 2021.

Keywords: Flavonoids, Glycosides, Natural products, Antibacterial activity, Phenolic secondary metabolites, Plant.

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Graphical Abstract
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