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Current Organic Synthesis


ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Review Article

A Review on Novel Synthesis Approaches and Biological Activities of 1,2,4- Oxadiazole and 1,3,4-Oxadiazole Tailored Compounds

Author(s): Tarun Chaudhary* and Prabhat Kumar Upadhyay

Volume 19, Issue 6, 2022

Published on: 29 April, 2022

Page: [731 - 747] Pages: 17

DOI: 10.2174/1570179419666220216122238

Price: $65


Rational design and synthesis of novel compounds with both effectivity and safety properties have always been a formidable task in the development of drugs. Oxadiazoles are heterocyclic bioscaffolds occurring as motifs in drug-like molecules. This review article highlights comprehensive and systematic information of compounds containing 1,2,4-oxadiazoles and 1,3,4-oxadiazole rings. The routes for the synthesis of the oxadiazoles have also been discussed, along with their biological significance. This review may help researchers in rational design for the development of effective and less toxic 1,3,4- oxadiazole based compounds. We present an informative review about the drugs derived from oxadiazole rings and their therapeutic application as well as a brief remark on the future development prospects.

Keywords: Organic derivatives, bioscaffolds, heterocyclic compounds, synthetic chemistry, rational design, oxadiazole.

Graphical Abstract
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