Abstract
The past decade has witnessed significant progress in highly regioselective direct arylation of azoles with aryl halides. This account aims to summarize recent progress in the development and application of these reactions. In particular, it describes and comments on the results obtained in the development of efficient protocols for the selective Pdcatalyzed direct C-5 arylation of 1-aryl-1H-imidazoles, 1-benzyl-1H-imidazole and 1-methyl-1H-imidazole and the highly regioselective Pd-catalyzed and Cu-mediated direct C-2 arylation of azoles, including free (NH)-imidazole, - benzimidazole and -indole. The utility of these novel protocols for the concise and efficient preparation of 1,5-diaryl- and 1,2-diaryl-1H-imidazoles, including derivatives of potential pharmacological interest, 4(5)-aryl-, 4,5-diaryl- and 4,5- diaryl-1-methyl-1H-imidazoles, 2-arylbenzothiazoles and 2-arylbenzimidazoles, including bioactive compounds or their precursors, and 2,4(5)-diaryl-1H-imidazoles is also disclosed. Finally, this account illustrates the results of an attempt to optimize a protocol for the direct C-2 arylation of 1H-indole, which enabled the development of a new, convenient and functional group-tolerant version of the Ullmann reaction for the Cu-mediated highly regioselective N-arylation of 1Hindole derivatives and 9H-carbazole.
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Cutting-edge technology for the development of electrochemical sensors
Electrochemistry based point of care diagnostics is a powerful tool which can revolutionize the current concept of personalize health care industry. There have been several efforts to amalgamate cutting edge technologies (nanotechnology, surface technology, anti-biofouling strategies) while developing assays. The success of each electrochemical sensor is very dependable upon how ...read more
Electrochemical C-X bond formation
Conventional methods for carrying out carbon–X bond formation are typically conducted at harsh reaction conditions, and rely on expensive catalysts as well as the use of stoichiometric, and perhaps toxic, oxidants. In this regard, electrochemical synthesis has recently been recognized as a sustainable and scalable strategy for the construction of ...read more
Related Books
2-Deoxy-D-Glucose: Chemistry and Biology
Chiral Ionic Liquids: Applications in Chemistry and Technology
Basics of Organic Chemistry: A Textbook for Undergraduate Students
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
20
