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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Cellular and Molecular Mechanisms of Curcumin in Thyroid Gland Disorders

Author(s): Farzaneh Shakeri, Bahram Bibak, Mohammad Reza Safdari, Zakieh Keshavarzi, Tannaz Jamialahmadi, Thozhukat Sathyapalan* and Amirhossein Sahebkar*

Volume 29, Issue 16, 2022

Published on: 24 March, 2022

Page: [2878 - 2890] Pages: 13

DOI: 10.2174/0929867329666220210145033

Price: $65


There is growing literature on the positive therapeutic potentials of curcumin. Curcumin or diferuloylmethane is a polyphenol obtained from the plant Curcuma longa. Curcumin is widely used in Ayurvedic and Chinese medicine for various conditions. The role of curcumin in thyroid gland disorders has been demonstrated by its effects on various biological pathways, including anti-inflammatory, antioxidant, anti-proliferative, apoptosis, angiogenesis, cell cycle and metastasis. In this paper, we have reviewed the recent literature on curcumin applications for thyroid dysfunction, including hyperthyroidism and hypothyroidism, and discussed the molecular mechanisms of these effects. This review aims to summarize the wealth of research related to the therapeutic effect of curcumin on the thyroid gland.

Keywords: Curcumin, thyroid gland, molecular mechanisms, hormones, thyrotropin, pituitary gland.

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