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Infectious Disorders - Drug Targets


ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

Mini-Review Article

Third Wave of the COVID-19 Pandemic: Prominence of Initial Public Health Interference

Author(s): Sukhes Mukherjee* and Suman Kumar Ray

Volume 22, Issue 4, 2022

Published on: 15 March, 2022

Article ID: e080222200919 Pages: 6

DOI: 10.2174/1871526522666220208115101

Price: $65


Since the first news of a coronavirus-related pneumonia outbreak in December 2019, the virus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), which causes COVID-19, has spread worldwide, with more than 100 million people infected in over 210 countries and two million deaths. In the UK (B.1.1.7), South Africa (B.1.351), Brazil (P.1), and India (B.1.617), independent SARS-CoV-2 lineages have recently been established. The virus accesses these variants via the angiotensin- converting enzyme-2 (ACE2) receptor due to several mutations in the immune-dominant spike protein. SARS-CoV-2 has caused substantial morbidity and mortality, as well as significant strain on public health systems and the global economy, due to the severity and intensity at which it has spread. COVID-19 vaccines have shown to be highly successful in clinical trials and can be used to fight the pandemic. The COVID-19 pandemic’s environmental trends change at breakneck speed, making predictions based on traditional epidemiological knowledge particularly speculative. Following the first outbreak, the second wave of COVID-19 swept across the globe, infecting various countries. The third wave of coronavirus infection has already been experienced in a few countries. Many of us have said, "When this is over," but what exactly does that mean? Since the virus’s first-, second-, and third-order effects manifest over various time periods, the pandemic will not be considered ‘over’ until the ‘third phase’ of the COVID-19 pandemic has passed. It is the best time to take preventative steps and immunize ourselves with vaccines in order to prepare for the predicted third wave of COVID-19 in some countries. In order to effectively suppress and monitor the COVID-19 pandemic, early and timely measures with improved social distancing policies should be enforced. We must continue critical public health efforts to suppress transmission and reduce mortality while working toward the rollout of a safe and efficient vaccine, and we must have the patience to listen, learn, improve, innovate, and evolve.

Keywords: SARS-CoV-2, COVID-19 vaccines, pandemic, new variants, public health, respiratory droplets.

Graphical Abstract
Guo YR, Cao QD, Hong ZS, et al. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. Mil Med Res 2020; 7(1): 11.
[] [PMID: 32169119]
Li R, Pei S, Chen B, et al. Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2). Science 2020; 368(6490): 489-93.
[] [PMID: 32179701]
Xu TL, Ao MY, Zhou X, et al. China’s practice to prevent and control COVID-19 in the context of large population movement. Infect Dis Poverty 2020; 9(1): 115.
[] [PMID: 32814591]
Zheng J. SARS-CoV-2: An emerging coronavirus that causes a global threat. Int J Biol Sci 2020; 16(10): 1678-85.
[] [PMID: 32226285]
Shereen MA, Khan S, Kazmi A, Bashir N, Siddique R. COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses. J Adv Res 2020; 24: 91-8.
[] [PMID: 32257431]
Decaro N, Lorusso A. Novel human coronavirus (SARS-CoV-2): A lesson from animal coronaviruses. Vet Microbiol 2020; 244: 108693.
[] [PMID: 32402329]
Woo PC, Lau SK, Lam CS, et al. Discovery of seven novel Mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and deltacoronavirus. J Virol 2012; 86(7): 3995-4008.
[] [PMID: 22278237]
Subbarao K, Mahanty S. Respiratory virus infections: Understanding COVID-19. Immunity 2020; 52(6): 905-9.
[] [PMID: 32497522]
Jayaweera M, Perera H, Gunawardana B, Manatunge J. Transmission of COVID-19 virus by droplets and aerosols: A critical review on the unresolved dichotomy. Environ Res 2020; 188: 109819.
[] [PMID: 32569870]
Dhand R, Li J. Coughs and sneezes: Their role in transmission of respiratory viral infections, including SARS-CoV-2. Am J Respir Crit Care Med 2020; 202(5): 651-9.
[] [PMID: 32543913]
Kampf G, Todt D, Pfaender S, Steinmann E. Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents. J Hosp Infect 2020; 104(3): 246-51.
[] [PMID: 32035997]
Ray SK, Mukherjee S. Understanding the role of corona virus based on current scientific evidence - a review with emerging importance in pandemic. Recent Patents Anti-Infect Drug Disc 2020; 15(2): 89-103.
[] [PMID: 32957894]
Ridenhour B, Kowalik JM, Shay DK. Unraveling R0: Considerations for public health applications. Am J Public Health 2014; 104(2): e32-41.
[] [PMID: 24328646]
Sanche S, Lin YT, Xu C, Romero-Severson E, Hengartner N, Ke R. High contagiousness and rapid spread of severe acute respiratory syndrome coronavirus 2. Emerg Infect Dis 2020; 26(7): 1470-7.
[] [PMID: 32255761]
Demongeot J, Flet-Berliac Y, Seligmann H. Temperature decreases spread parameters of the new covid-19 cases dynamics. Biology (Basel) 2020; 9(5): 94.
Seligmann H, Iggui S, Rachdi M, Vuillerme N, Demongeot J. 2020 Inverted covariate effects for first vs mutated second wave Covid-19: High temperature spread biased for young. Biology (Basel) 2020; 9(8): 226.
[] [PMID: 32823981]
Forster P, Forster L, Renfrew C, Forster M. Phylogenetic network analysis of SARS-CoV-2 genomes. Proc Natl Acad Sci USA 2020; 117(17): 9241-3.
[] [PMID: 32269081]
Bambra C, Riordan R, Ford J, Matthews F. The COVID-19 pandemic and health inequalities. J Epidemiol Community Health 2020; 74(11): 964-8.
[PMID: 32535550]
Mishra V, Seyedzenouzi G, Almohtadi A, et al. Health inequalities during COVID-19 and their effects on morbidity and mortality. J Healthc Leadersh 2021; 13: 19-26.
[] [PMID: 33500676]
Pereda N, Díaz-Faes DA. Family violence against children in the wake of COVID-19 pandemic: A review of current perspectives and risk factors. Child Adolesc Psychiatry Ment Health 2020; 14(1): 40.
[] [PMID: 33088340]
Zhou D, Dejnirattisai W, Supasa P, et al. Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera. Cell 2021; 184(9): 2348-2361.e6.
[] [PMID: 33730597]
Planas D, Bruel T, Grzelak L, et al. Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies. Nat Med 2021; 27(5): 917-24.
[] [PMID: 33772244]
Arambepola C, Wickramasinghe ND, Jayakody S, et al. Sri Lanka’s early success in the containment of COVID-19 through its rapid response: Clinical & epidemiological evidence from the initial case series. PLoS One 2021; 16(7): e0255394.
[] [PMID: 34324587]
Ray SK, Mukherjee S. From bench side to bed-travelling on a road to get a safe and effective vaccine against COVID-19, day to save the life. Rec Pat Biotechnol 2021.
[] [PMID: 34886784]
Ray SK, Mukherjee S. The spectrum of biochemical alterations with molecular and serological biomarkers in the diagnosis of COVID-19: Searching for novel one to identify disease earlier with better prognosis and drug discovery. Rec Adv Antiinfect Drug Discov 2021.
[] [PMID: 34809554]
Harvey WT, Carabelli AM, Jackson B, et al. SARS-CoV-2 variants, spike mutations and immune escape. Nat Rev Microbiol 2021; 19(7): 409-24.
[] [PMID: 34075212]
Huang B, Wang J, Cai J, et al. Integrated vaccination and physical distancing interventions to prevent future COVID-19 waves in Chinese cities. Nat Hum Behav 2021; 5(6): 695-705.
[] [PMID: 33603201]
Ahmed F, Zviedrite N, Uzicanin A. Effectiveness of workplace social distancing measures in reducing influenza transmission: A systematic review. BMC Public Health 2018; 18(1): 518.
[] [PMID: 29669545]
Noh JY, Seong H, Yoon JG, Song JY, Cheong HJ, Kim WJ. Social distancing against COVID-19: Implication for the control of influenza. J Korean Med Sci 2020; 35(19): e182.
[] [PMID: 32419400]
Seong H, Hyun HJ, Yun JG, et al. Comparison of the second and third waves of the COVID-19 pandemic in South Korea: Importance of early public health intervention. Int J Infect Dis 2021; 104: 742-5.
[] [PMID: 33556610]
Petersen E, Koopmans M, Go U, et al. Comparing SARS-CoV-2 with SARS-CoV and influenza pandemics. Lancet Infect Dis 2020; 20(9): e238-44.
[] [PMID: 32628905]
Rypdal K, Bianchi FM, Rypdal M. Intervention fatigue is the primary cause of strong secondary waves in the COVID-19 pandemic. Int J Environ Res Public Health 2020; 17(24): 9592.
[] [PMID: 33371489]

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