Generic placeholder image

Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

New Biochemical Markers in Acute Coronary Syndromes

Author(s): Dimitris Tousoulis, Anna-Maria Kampoli, Elli Stefanadi, Charalambos Antoniades, Gerasimos Siasos, Athanasios G. Papavassiliou and Christodoulos Stefanadis

Volume 15, Issue 13, 2008

Page: [1288 - 1296] Pages: 9

DOI: 10.2174/092986708784534965

Price: $65


This article comments on the role of the most important biochemical markers that are already applied in clinical practice or are still under research, in Acute Coronary Syndromes (ACS). Cardiac troponin (cTn) is established as the ‘gold standard’ in the diagnosis of ACS. C-reactive protein (CRP) and especially high-sensitivity CRP (hs-CRP) are considered to be the most useful inflammatory markers for clinical practice in the setting of acute coronary syndrome. Brain-type natriuretic peptide (BNP) and the amino terminal fragment of the prohormone BNP (NT-proBNP) appear to provide prognostic information in individuals admitted for acute coronary syndromes. Microalbuminuria in nondiabetics appears to be a signal from the kidney that the vasculature, particularly the endothelium, is not functioning properly. Increased plasma levels of cystatin C, neopterin, myeloperoxidase, and pregnancy associated protein are associated with adverse cardiovascular outcomes, cardiovascular and noncardiovascular death, and possibly cerebrovascular disease. Furthermore, recent evidence suggests that serum levels of CD40-CD40L pathway exert important roles in progression, and outcome of acute coronary syndrome. In the future further, studies are necessary to elucidate the exact role of the new biochemical markers in ACS.

Keywords: Acute coronary syndromes, Troponin, Biomarkers, Inflammation

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy