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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Review Article

An Update on the Synthesis and Pharmacological Properties of Pyrazoles Obtained from Chalcone

Author(s): Jaqueline E. Queiroz, Lucas D. Dias, Giuliana M. Vila Verde, Gilberto L.B. Aquino* and Ademir J. Camargo

Volume 26, Issue 2, 2022

Published on: 31 January, 2022

Page: [81 - 90] Pages: 10

DOI: 10.2174/1385272826666220119110347

Price: $65


A review concerning the synthesis and pharmacological properties of pyrazoles obtained from Chalcone described in the literature over the last 5 years (2016-2020) was presented and discussed. Among the synthetic approaches for pyrazoles described so far, the cyclization and acetylation method of α,β-unsaturated chalcones, and substituted hydrazine were selected and analyzed. 105 pyrazole derivatives (3-107) were evaluated as well as their pharmacological activities, namely, antineoplastic, anti-inflammatory, antioxidant, antibacterial, antifungal, antimycobacterial, antiplasmodial, Alzheimer's disease, enzymes inhibition (like acetylcholinesterase, carbonic anhydrase, and malonyl CoA decarboxylase), anticonvulsant, among others. Pyrazolic compounds are widely used in the design of the new drug with a wide spectrum of pharmacological approaches. Therefore, it is relevant to research the synthetic methods and therapeutic properties of different pyrazole derivatives.

Keywords: Synthesis, chalcones, pyrazoles, biological activities, antimicrobial, antineoplastic.

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